| 词条 | Hypersegmented neutrophil |
| 释义 |
| name = Hypersegmented neutrophil | image = Image:Hypersegmented neutrophil.png|thumb| | alt = | caption = Blood smear with two hypersegmented neutrophils. | pronounce = | synonyms = | reference_range = | calculator = | DiseasesDB = | ICD10 = | ICD9 = | ICDO = | MedlinePlus = | eMedicine = | MeshID = | OPS301 = | LOINC = }} Neutrophil hypersegmentation can be defined as the presence of neutrophils whose nuclei have six or more lobes or the presence of more than 3% of neutrophils with at least five nuclear lobes.[1] This is a clinical laboratory finding. It is visualized by drawing blood from a patient and viewing the blood smeared on a slide under a microscope. Normal neutrophils are uniform in size, with an apparent diameter of about 13 μm in a film. When stained, neutrophils have a segmented nucleus and pink/orange cytoplasm under light microscope. The majority of neutrophils have three nuclear segments (lobes) connected by tapering chromatin strands. A small percentage have four lobes, and occasionally five lobes may be seen. Up to 8% of circulating neutrophils are unsegmented (‘band’ forms)[2]. The presence of hypersegmented neutrophils is an important diagnostic feature of megaloblastic anaemias. Hypersegmentation can also be seen in many other condition but with relatively less diagnostic significance. Hypersegmentation can sometimes be difficult to assert since interobserver variation is high, and important to note is that blacks have a greater neutrophil segmentation than whites[3][4]. Association with other diseasesMegaloblastic anemiaNeutrophil hypersegmentation is one of the earliest, most sensitive and specific signs of megaloblastic anemia (mainly caused by hypovitaminosis of vitamin B12 & folic acid). Nuclear hypersegmentation of DNA in neutrophils strongly suggests megaloblastosis when associated with macro-ovalocytosis. If megaloblastosis is suspected, a formal lobe count/neutrophil (i.e. lobe index) above 3.5% can be obtained. Hypersegmentation persists for an average of 14 days after institution of specific therapy.{{citation needed|date=February 2019}} Other causes
References1. ^{{Cite book|url=https://books.google.com/?id=rEPUDAAAQBAJ&pg=PA85&dq=six+or+more+lobes+or+the+presence+of+more+than+3%25+of+neutrophils+with+at+least+five+lobes#v=onepage&q=six%20or%20more%20lobes%20or%20the%20presence%20of%20more%20than%203%25%20of%20neutrophils%20with%20at%20least%20five%20lobes&f=false|title=Dacie and Lewis Practical Haematology E-Book|last=Bain|first=Barbara J.|last2=Bates|first2=Imelda|last3=Laffan|first3=Mike A.|date=2016-08-11|publisher=Elsevier Health Sciences|isbn=9780702069253|language=en}} {{pathology}}{{Abnormal clinical and laboratory findings for blood}}{{DEFAULTSORT:Hypersegmented Neutrophil}}2. ^{{Cite book|url=https://books.google.com/?id=rEPUDAAAQBAJ&pg=PA85&dq=six+or+more+lobes+or+the+presence+of+more+than+3%25+of+neutrophils+with+at+least+five+lobes#v=onepage&q=six%20or%20more%20lobes%20or%20the%20presence%20of%20more%20than%203%25%20of%20neutrophils%20with%20at%20least%20five%20lobes&f=false|title=Dacie and Lewis Practical Haematology E-Book|last=Bain|first=Barbara J.|last2=Bates|first2=Imelda|last3=Laffan|first3=Mike A.|date=2016-08-11|publisher=Elsevier Health Sciences|isbn=9780702069253|language=en}} 3. ^{{Cite journal|last=Carmel|first=R.|last2=Green|first2=R.|last3=Jacobsen|first3=D. W.|last4=Qian|first4=G. D.|date=July 1996|title=Neutrophil nuclear segmentation in mild cobalamin deficiency: relation to metabolic tests of cobalamin status and observations on ethnic differences in neutrophil segmentation|journal=American Journal of Clinical Pathology|volume=106|issue=1|pages=57–63|issn=0002-9173|pmid=8701933}} 4. ^{{Cite book|url=https://books.google.com/?id=NYCeAgAAQBAJ&pg=PA938&lpg=PA938&dq=blacks+have+a+greater+neutrophil+segmentation+than+whites#v=onepage&q=blacks%20have%20a%20greater%20neutrophil%20segmentation%20than%20whites&f=false|title=Wintrobe's Clinical Hematology|last=Arber|first=Daniel A.|last2=Glader|first2=Bertil|last3=List|first3=Alan F.|last4=Means|first4=Robert T.|last5=Paraskevas|first5=Frixos|last6=Rodgers|first6=George M.|date=2013-08-29|publisher=Lippincott Williams & Wilkins|isbn=9781469846224|language=en}} 5. ^{{Cite book|url=https://books.google.com/?id=b0aw2SLzZQ8C&pg=PA556&dq=hereditary+hypersegmentation#v=onepage&q=hereditary%20hypersegmentation&f=false|title=Desk Reference for Hematology, Second Edition|last=Shinton|first=N. K.|date=2007-12-19|publisher=CRC Press|isbn=9781420005127|language=en}} 6. ^{{Cite book|url=https://books.google.com/?id=fndcMwFi0KgC&pg=PA73&dq=anderson+atlas+nuclear+hypersegmentation#v=onepage&q=anderson%20atlas%20nuclear%20hypersegmentation&f=false|title=Anderson's Atlas of Hematology|last=Anderson|first=Shauna|date=2013-01-24|publisher=Lippincott Williams & Wilkins|isbn=9781469826363|language=en}} 7. ^{{Cite book|url=https://books.google.com/?id=Vh6c9i_umwYC&pg=PA42&dq=wintrobe+following+granulocyte+colony%E2%80%93+stimulating+factor+(G-CSF)+administration,+and+in+chronic+infections.#v=onepage&q=wintrobe%20following%20granulocyte%20colony%E2%80%93%20stimulating%20factor%20(G-CSF)%20administration,%20and%20in%20chronic%20infections.&f=false|title=Wintrobe's Atlas of Clinical Hematology|last=Tkachuk|first=Douglas C.|last2=Hirschmann|first2=Jan V.|last3=Wintrobe|first3=Maxwell Myer|date=2007|publisher=Lippincott Williams & Wilkins|isbn=9780781770231|language=en}} 8. ^{{Cite book|url=https://books.google.com/?id=Vh6c9i_umwYC&pg=PA42&dq=wintrobe+following+granulocyte+colony%E2%80%93+stimulating+factor+(G-CSF)+administration,+and+in+chronic+infections.#v=onepage&q=wintrobe%20following%20granulocyte%20colony%E2%80%93%20stimulating%20factor%20(G-CSF)%20administration,%20and%20in%20chronic%20infections.&f=false|title=Wintrobe's Atlas of Clinical Hematology|last=Tkachuk|first=Douglas C.|last2=Hirschmann|first2=Jan V.|last3=Wintrobe|first3=Maxwell Myer|date=2007|publisher=Lippincott Williams & Wilkins|isbn=9780781770231|language=en}} 9. ^{{Cite book|url=https://books.google.com/?id=rEPUDAAAQBAJ&pg=PA85&dq=six+or+more+lobes+or+the+presence+of+more+than+3%25+of+neutrophils+with+at+least+five+lobes#v=onepage&q=hydroxycarbamide&f=false|title=Dacie and Lewis Practical Haematology E-Book|last=Bain|first=Barbara J.|last2=Bates|first2=Imelda|last3=Laffan|first3=Mike A.|date=2016-08-11|publisher=Elsevier Health Sciences|isbn=9780702069253|language=en}} 10. ^{{Cite book|url=https://books.google.com/?id=rEPUDAAAQBAJ&pg=PA85&dq=six+or+more+lobes+or+the+presence+of+more+than+3%25+of+neutrophils+with+at+least+five+lobes#v=onepage&q=hydroxycarbamide&f=false|title=Dacie and Lewis Practical Haematology E-Book|last=Bain|first=Barbara J.|last2=Bates|first2=Imelda|last3=Laffan|first3=Mike A.|date=2016-08-11|publisher=Elsevier Health Sciences|isbn=9780702069253|language=en}} 11. ^{{Cite book|url=https://books.google.com/?id=Vh6c9i_umwYC&pg=PA42&dq=wintrobe+following+granulocyte+colony%E2%80%93+stimulating+factor+(G-CSF)+administration,+and+in+chronic+infections.#v=onepage&q=wintrobe%20following%20granulocyte%20colony%E2%80%93%20stimulating%20factor%20(G-CSF)%20administration,%20and%20in%20chronic%20infections.&f=false|title=Wintrobe's Atlas of Clinical Hematology|last=Tkachuk|first=Douglas C.|last2=Hirschmann|first2=Jan V.|last3=Wintrobe|first3=Maxwell Myer|date=2007|publisher=Lippincott Williams & Wilkins|isbn=9780781770231|language=en}} 12. ^{{Cite book|url=https://books.google.com/?id=NYCeAgAAQBAJ&pg=PA1294&dq=wintrobe+Hypersegmentation+of+neutrophil+nuclei#v=onepage&q=Hypersegmentation%20of%20neutrophil%20nuclei&f=false|title=Wintrobe's Clinical Hematology|last=Arber|first=Daniel A.|last2=Glader|first2=Bertil|last3=List|first3=Alan F.|last4=Means|first4=Robert T.|last5=Paraskevas|first5=Frixos|last6=Rodgers|first6=George M.|date=2013-08-29|publisher=Lippincott Williams & Wilkins|isbn=9781469846224|language=en}} 9 : Monocyte and granulocyte disorders|Histology|Cell biology|Granulocytes|Phagocytes|Human cells|Anatomical pathology|Histopathology|Hematopathology |
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