| 词条 | Hypotaurine |
| 释义 |
| verifiedrevid = 443866826 | ImageFile = Hypotaurine.png | ImageSize = 180px | ImageAlt = Skeletal formula of Hypotaurine | ImageFile1 = Hypotaurine zwitterion ball.png | ImageAlt1 = Ball-and-stick model of the hypotaurine zwitterion | IUPACName = 2-Aminoethanesulfinic acid | OtherNames= |Section1 = {{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 96959 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = C00519 | InChI = 1/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) | InChIKey = VVIUBCNYACGLLV-UHFFFAOYAM | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = VVIUBCNYACGLLV-UHFFFAOYSA-N | CASNo_Ref = {{cascite|correct|??}} | CASNo=300-84-5 | PubChem=107812 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 5L08GE4332 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 57853 | SMILES = O=S(O)CCN }} |Section2={{Chembox Properties | Formula=C2H7NO2S | MolarMass=109.15 g/mol | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Hypotaurine is a sulfinic acid that is an intermediate in the biosynthesis of taurine. Like taurine, it also acts as an endogenous neurotransmitter via action on the glycine receptors.[1] Hypotaurine is derived from cysteine (and homocysteine). In mammals, the biosynthesis of hypotaurine from cysteine occurs in the pancreas. In the cysteine sulfinic acid pathway, cysteine is first oxidized to its sulfinic acid, catalyzed by the enzyme cysteine dioxygenase. Cysteine sulfinic acid, in turn, is decarboxylated by sulfinoalanine decarboxylase to form hypotaurine. Hypotaurine is enzymatically oxidized to yield taurine by hypotaurine dehydrogenase.[2] {{clear}}References1. ^Kalir, Asher; Kalir, Henry H. "Biological activity of sulfinic acid derivatives" in Chemistry of Sulphinic Acids, Esters Their Derivatives Edited by Patai, Saul. Wiley, New York, 1990, pp. 665. {{Neurotransmitters}}{{Glycinergics}}{{nervous-system-drug-stub}}2. ^{{Cite journal | author = Sumizu K | date = 1962 | title = Oxidation of hypotaurine in rat liver | journal = Biochim. Biophys. Acta | volume = 63 | pages = 210–212 | doi = 10.1016/0006-3002(62)90357-8 | pmid=13979247}} 3 : Amines|Sulfinic acids|Glycine receptor agonists |
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