“ID3 (gene)”的意思、由来-开放百科全书

Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.[supplied by OMIM]^[2]

References

1. ^{{cite journal | vauthors = Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A | title = Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development | journal = EMBO J. | volume = 11 | issue = 7 | pages = 2563–71 | date = Aug 1992 | pmid = 1628620 | pmc = 556731 | doi = 10.1002/j.1460-2075.1992.tb05321.x}}
2. ^¹{{cite web | title = Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3399| accessdate = }}
3. ^{{cite journal | vauthors = Deed RW, Jasiok M, Norton JD | title = Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells | journal = J. Biol. Chem. | volume = 273 | issue = 14 | pages = 8278–86 | date = Apr 1998 | pmid = 9525934 | doi = 10.1074/jbc.273.14.8278 }}
4. ^{{cite journal | vauthors = Langlands K, Yin X, Anand G, Prochownik EV | title = Differential interactions of Id proteins with basic-helix-loop-helix transcription factors | journal = J. Biol. Chem. | volume = 272 | issue = 32 | pages = 19785–93 | date = Aug 1997 | pmid = 9242638 | doi = 10.1074/jbc.272.32.19785 }}
5. ^{{cite journal | vauthors = Farioli-Vecchioli S, Saraulli D, Costanzi M, Leonardi L, Cinà I, Micheli L, Nutini M, Longone P, Oh SP, Cestari V, Tirone F | title = Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice | journal = PLoS ONE | volume = 4 | issue = 12 | pages = e8339 | year = 2009 | pmid = 20020054 | pmc = 2791842 | doi = 10.1371/journal.pone.0008339 | editor1-last = Okazawa | editor1-first = Hitoshi }}

Further reading

{{cite journal | vauthors = White PS, Maris JM, Beltinger C, Sulman E, Marshall HN, Fujimori M, Kaufman BA, Biegel JA, Allen C, Hilliard C, Valentine MB, Look AT, Enomoto H, Sakiyama S, Brodeur GM | title = A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 12 | pages = 5520–4 | year = 1995 | pmid = 7777541 | pmc = 41727 | doi = 10.1073/pnas.92.12.5520 }}

{{cite journal | vauthors = Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T | title = Construction of a human full-length cDNA bank | journal = Gene | volume = 150 | issue = 2 | pages = 243–50 | year = 1994 | pmid = 7821789 | doi = 10.1016/0378-1119(94)90433-2 }}

{{cite journal | vauthors = Deed RW, Hirose T, Mitchell EL, Santibanez-Koref MF, Norton JD | title = Structural organisation and chromosomal mapping of the human Id-3 gene | journal = Gene | volume = 151 | issue = 1–2 | pages = 309–14 | year = 1994 | pmid = 7828896 | doi = 10.1016/0378-1119(94)90676-9 }}

{{cite journal | vauthors = Deed RW, Bianchi SM, Atherton GT, Johnston D, Santibanez-Koref M, Murphy JJ, Norton JD | title = An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types | journal = Oncogene | volume = 8 | issue = 3 | pages = 599–607 | year = 1993 | pmid = 8437843 | doi = }}

{{cite journal | vauthors = Ishiguro A, Spirin K, Shiohara M, Tobler A, Norton JD, Rigolet M, Shimbo T, Koeffler HP | title = Expression of Id2 and Id3 mRNA in human lymphocytes | journal = Leuk. Res. | volume = 19 | issue = 12 | pages = 989–96 | year = 1995 | pmid = 8632670 | doi = 10.1016/0145-2126(95)00084-4 }}

{{cite journal | vauthors = Wibley J, Deed R, Jasiok M, Douglas K, Norton J | title = A homology model of the Id-3 helix-loop-helix domain as a basis for structure-function predictions | journal = Biochim. Biophys. Acta | volume = 1294 | issue = 2 | pages = 138–46 | year = 1996 | pmid = 8645731 | doi = 10.1016/0167-4838(96)00008-8 }}

{{cite journal | vauthors = Loveys DA, Streiff MB, Kato GJ | title = E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein | journal = Nucleic Acids Res. | volume = 24 | issue = 14 | pages = 2813–20 | year = 1996 | pmid = 8759016 | pmc = 145994 | doi = 10.1093/nar/24.14.2813 }}

{{cite journal | vauthors = Deed RW, Armitage S, Norton JD | title = Nuclear localization and regulation of Id protein through an E protein-mediated chaperone mechanism | journal = J. Biol. Chem. | volume = 271 | issue = 39 | pages = 23603–6 | year = 1996 | pmid = 8798572 | doi = 10.1074/jbc.271.39.23603 }}

{{cite journal | vauthors = Deed RW, Jasiok M, Norton JD | title = Attenuated function of a variant form of the helix-loop-helix protein, Id-3, generated by an alternative splicing mechanism | journal = FEBS Lett. | volume = 393 | issue = 1 | pages = 113–6 | year = 1996 | pmid = 8804437 | doi = 10.1016/0014-5793(96)00868-X }}

{{cite journal | vauthors = Chen B, Lim RW | title = Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression | journal = J. Biol. Chem. | volume = 272 | issue = 4 | pages = 2459–63 | year = 1997 | pmid = 8999959 | doi = 10.1074/jbc.272.4.2459 }}

{{cite journal | vauthors = Langlands K, Yin X, Anand G, Prochownik EV | title = Differential interactions of Id proteins with basic-helix-loop-helix transcription factors | journal = J. Biol. Chem. | volume = 272 | issue = 32 | pages = 19785–93 | year = 1997 | pmid = 9242638 | doi = 10.1074/jbc.272.32.19785 }}

{{cite journal | vauthors = Deed RW, Hara E, Atherton GT, Peters G, Norton JD | title = Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation | journal = Mol. Cell. Biol. | volume = 17 | issue = 12 | pages = 6815–21 | year = 1997 | pmid = 9372912 | pmc = 232537 | doi = 10.1128/MCB.17.12.6815}}

{{cite journal | vauthors = Deed RW, Jasiok M, Norton JD | title = Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells | journal = J. Biol. Chem. | volume = 273 | issue = 14 | pages = 8278–86 | year = 1998 | pmid = 9525934 | doi = 10.1074/jbc.273.14.8278 }}

{{cite journal | vauthors = Asp J, Thornemo M, Inerot S, Lindahl A | title = The helix-loop-helix transcription factors Id1 and Id3 have a functional role in control of cell division in human normal and neoplastic chondrocytes | journal = FEBS Lett. | volume = 438 | issue = 1–2 | pages = 85–90 | year = 1998 | pmid = 9821964 | doi = 10.1016/S0014-5793(98)01268-X }}

{{cite journal | vauthors = Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD | title = Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors | journal = EMBO J. | volume = 18 | issue = 4 | pages = 968–76 | year = 1999 | pmid = 10022839 | pmc = 1171189 | doi = 10.1093/emboj/18.4.968 }}

{{cite journal | vauthors = Moldes M, Boizard M, Liepvre XL, Fève B, Dugail I, Pairault J | title = Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes | journal = Biochem. J. | volume = 344 Pt 3 | issue = 3| pages = 873–80 | year = 1999 | pmid = 10585876 | pmc = 1220711 | doi = 10.1042/0264-6021:3440873 | series = 344 }}

{{cite journal | vauthors = Bounpheng MA, Dimas JJ, Dodds SG, Christy BA | title = Degradation of Id proteins by the ubiquitin-proteasome pathway | journal = FASEB J. | volume = 13 | issue = 15 | pages = 2257–64 | year = 1999 | pmid = 10593873 | doi = 10.1096/fasebj.13.15.2257}}

{{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs | journal = Genome Res. | volume = 11 | issue = 10 | pages = 1758–65 | year = 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}

{{cite journal | vauthors = Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H | title = Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation | journal = J. Biol. Chem. | volume = 277 | issue = 11 | pages = 9118–26 | year = 2002 | pmid = 11756408 | doi = 10.1074/jbc.M107713200 }}

Function

Interactions

Repressors of ID3

See also

References

Further reading

External links