| 词条 | Idalopirdine |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 451553711 | IUPAC_name = 2-(6-Fluoro-1H-indol-3-yl)-N-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)ethanamine | image = Lu-AE58054.svg | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 467459-31-0 | ATC_prefix = None | ATC_suffix = | PubChem = | ChEMBL = 3286580 | synonyms = Lu-AE-58054 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 19878969 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D10710 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 59WCJ0YNWM | smiles = FC(F)C(F)(F)COc1cccc(c1)CNCCc3c[nH]c2cc(F)ccc23 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C20H19F5N2O/c21-15-4-5-17-14(11-27-18(17)9-15)6-7-26-10-13-2-1-3-16(8-13)28-12-20(24,25)19(22)23/h1-5,8-9,11,19,26-27H,6-7,10,12H2 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = YBAWYTYNMZWMMJ-UHFFFAOYSA-N | C=20 | H=19 | F=5 | N=2 | O=1 | molecular_weight = 398.37 g/mol }}Idalopirdine (INN) (code names Lu AE58054,) is a potent and selective 5-HT6 receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia.[1][2] As of October 2013 it is in phase III clinical trials.[3] A phase III trial of two different daily doses of Lu AE58054 on top of 10 mg of donepezil for mild-to-moderate Alzheimer's failed to meet its primary endpoint with either dose.[4] Two further phase III trials failed too, the company confirmed in early 2017.[4] See also
References1. ^{{cite web | url = http://www.lundbeckinc.com/usa/pipeline/default.asp | title = U.S. Development Programs. - Lundbeck | format = | work = | accessdate = }} 2. ^{{cite web | url = http://clinicaltrials.gov/ct2/results?term=Lu+AE58054 | title = Search of: Lu AE58054 - List Results - ClinicalTrials.gov | format = | work = | accessdate = }} 3. ^{{cite web | url = http://clinicaltrials.gov/ct2/results?term=Lu+AE58054 | title = Search of: Lu AE58054 - List Results - ClinicalTrials.gov | format = | work = | accessdate = }} 4. ^1 PhIII Alzheimer’s flop takes chunk out of Lundbeck, hits Axovant with aftershocks Sept 2016 External links
6 : 5-HT6 antagonists|Antidementia agents|Nootropics|Tryptamines|Organofluorides|Fluoroarenes |
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