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词条 Idiopathic scrotal calcinosis
释义

  1. Presentation

  2. Etiology

  3. Diagnostic

  4. Treatment

  5. Prognosis

  6. Epidemiology

  7. History

  8. See also

  9. References

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}}Idiopathic scrotal calcinosis (also known as idiopathic calcified nodules of the scrotum[1]) is a cutaneous condition characterized by calcification of the skin resulting from the deposition of calcium and phosphorus occurring on the scrotum.[2]{{rp|528}} However, the levels of calcium and phosphate in the blood are normal.[3] Idiopathic scrotal calcinosis typically affects young males, with an onset between adolescence and early adulthood.[3] The scrotal calcinosis appears, without any symptoms, as yellowish nodules that range in size from 1 mm to several centimeters.[5]

Presentation

  • Single or multiple hard, marble-like nodules of varying size affecting scrotal skin.
  • Nodules vary in size from a few millimeters to a few centimeters.
  • Usually start to appear in childhood or early adult life
  • Over time, nodules increase in number and size
  • Nodules may break down and discharge chalky material
  • Rarely, lesions may be polypoid
  • Usually asymptomatic

Etiology

The cause is not well defined.[5][4] Originally considered idiopathic condition. Now accepted that majority of cases develop from dystrophic calcification of cyst contents.

Diagnostic

  • Clinically Relevant Pathologic Features
  • Lesions slowly progress throughout life
    • They slowly increase in number and size
  • Nodules are mobile and do not attach to underlying structures
Pathologic Interpretation Pearls
  • Globular and granular purple deposits within dermis surrounded by giant cell granulomatous reaction
  • Sometimes remnants of cystic lesion can be identified
  • Very distinctive appearance with almost no histologic differential diagnosis.

Treatment

Treatment may involve surgery,[5] which is currently the only recommended intervention.[5] Surgery should include the removal of even small nodules, to prevent the recurrence of the scrotal calcinosis.[5]

Prognosis

  • Benign condition
  • Slow progression throughout life
  • Lesions remain discrete and do not become confluent

Epidemiology

  • Incidence: uncommon
  • Age: children and young adults

History

Scrotal calcinosis was first described in 1883 by Lewinski.[6]

See also

  • Calcinosis cutis
  • Skin lesion
  • List of cutaneous conditions

References

1. ^{{cite book |author1=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |pages= |isbn=1-4160-2999-0 |oclc= |doi= |accessdate=}}
2. ^{{cite book |author1=James, William D. |author2=Berger, Timothy G. |title=Andrews' Diseases of the Skin: clinical Dermatology |publisher=Saunders Elsevier |location= |year=2006 |pages= |isbn=0-7216-2921-0 |oclc= |doi= |accessdate=|display-authors=etal}}
3. ^{{cite journal|last=Grenader|first=Tal|author2=Shavit, Linda|title=Scrotal Calcinosis|journal=New England Journal of Medicine|date=Aug 18, 2011|volume=365|issue=7|pages=647–647|doi=10.1056/NEJMicm1013803}}
4. ^{{cite journal |vauthors=Dubey S, Sharma R, Maheshwari V |title=Scrotal calcinosis: idiopathic or dystrophic? |journal=Dermatol. Online J. |volume=16 |issue=2 |pages=5 |year=2010 |pmid=20178701 |doi= |url=http://dermatology.cdlib.org/1602/originals/calcinosis/dubey.html}}
5. ^{{cite journal |vauthors=Karaca M, Taylan G, Akan M, Eker G, Gideroglu K, Gul AE |title=Idiopathic Scrotal Calcinosis: Surgical Treatment and Histopathologic Evaluation of Etiology |journal=Urology |volume= 76|issue= 6|pages= 1493–1495|date=April 2010 |pmid=20381842 |doi=10.1016/j.urology.2010.02.001 |url=http://linkinghub.elsevier.com/retrieve/pii/S0090-4295(10)00186-X}}
6. ^{{cite journal|vauthors=Khallouk A, Yazami OE, Mellas S, Tazi MF, El Fassi J, Farih MH|title=Idiopathic scrotal calcinosis: a non-elucidated pathogenesis and its surgical treatment.|journal=Reviews in urology|date=2011|volume=13|issue=2|pages=95–7|pmid=21935341|pmc=3176555}}
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2 : Skin conditions resulting from errors in metabolism|Scrotum

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