| 词条 | Ifoxetine |
| 释义 |
| IUPAC_name = (3R,4S)-4-(2,3-dimethylphenoxy)piperidin-3-ol | image = Ifoxetine.png | tradename = | pregnancy_category = | legal_status = Uncontrolled | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 66208-11-5 | ATC_prefix = none | ATC_suffix = | PubChem = 71971 | ChEMBL = 2218865 | ChemSpiderID = 64977 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = LHH887104B | C=13 | H=19 | N=1 | O=2 | molecular_weight = 221.30 g/mol | smiles = O(c1cccc(c1C)C)[C@H]2CCNC[C@H]2O }}Ifoxetine (CGP-15,210-G) is a selective serotonin reuptake inhibitor (SSRI) which was investigated as an antidepressant in the 1980s but was never marketed.[1][2][3] Ifoxetine selectively blocks the reuptake of serotonin in the brain supposedly without affecting it in the periphery.[3] Supporting this claim, ifoxetine was found to be efficacious in clinical trials and was very well tolerated, producing almost no physical side effects or other complaints of significant concern.[3] References1. ^{{cite journal |vauthors=Burrows GD, McIntyre IM, Judd FK, Norman TR | title = Clinical effects of serotonin reuptake inhibitors in the treatment of depressive illness | journal = The Journal of Clinical Psychiatry | volume = 49 Suppl | issue = | pages = 18–22 |date=August 1988 | pmid = 3045107 | doi = | url = }} {{Antidepressants}}{{Monoamine reuptake inhibitors}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Waldmeier PC, Maître L, Baumann PA, etal | title = Ifoxetine, a compound with atypical effects on serotonin uptake | journal = European Journal of Pharmacology | volume = 130 | issue = 1-2 | pages = 1–10 |date=October 1986 | pmid = 2877890 | doi = 10.1016/0014-2999(86)90177-9| url = http://linkinghub.elsevier.com/retrieve/pii/0014-2999(86)90177-9}} 3. ^1 2 {{cite journal |vauthors=Delini-Stula A, Fischbach R, Gauthier JM, etal | title = First clinical experience with ifoxetine, a new 5-HT reuptake blocker with particular emphasis on the side-effect profile of the 5-HT-uptake inhibiting drugs | journal = International Clinical Psychopharmacology | volume = 2 | issue = 3 | pages = 201–15 |date=July 1987 | pmid = 3320185 | doi = 10.1097/00004850-198707000-00003| url = }} 5 : Alcohols|Antidepressants|Phenol ethers|Piperidines|Selective serotonin reuptake inhibitors |
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