“IFT20”的意思、由来-开放百科全书

Intraflagellar transport protein 20 homolog is a protein that in humans is encoded by the IFT20 gene.^[1] The gene is composed of 6 exons and is

located on human chromosome 17p11.1. This gene is expressed in human brain, lung, kidney and pancreas, and lower expression were also detected in human placenta, liver, thymus, prostate and testis.^[2]

Intraflagellar transport (IFT), in which molecular motors and IFT particle proteins participate, is very important in assembling and maintaining many cilia/flagella, such as the motile cilia that drive the swimming of cells and embryos, the nodal cilia that generate left-right asymmetry in vertebrate embryos, and the sensory cilia that detect sensory stimuli in some animals.^[2] IFT20 subunit of the particle is localized to the Golgi complex in addition to the basal body and cilia where all previous IFT particle proteins had been found. In living cells, fluorescently tagged IFT20 is highly dynamic and moves between the Golgi complex and the cilium as well as along ciliary microtubules.^[3] IFT20 has been shown to interact with SPEF2 in the testis, and plays a role in sperm motility.^[4]

References

1. ^{{cite web | title = Entrez Gene: IFT20 intraflagellar transport 20 homolog (Chlamydomonas)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90410| accessdate = }}
2. ^¹{{cite journal |vauthors=Yin G, Dai J, Ji C, Ni X, Shu G, Ye X, Dai J, Wu Q, Gu S, Xie Y, Zhao RC, Mao Y | title = Cloning and characterization of the human IFT20 gene | journal = Mol. Biol. Rep. | volume = 30 | issue = 4 | pages = 255–60 |date=December 2003 | pmid = 14672413 | doi = 10.1023/A:1026365124176| url = }}
3. ^{{cite journal |vauthors=Follit JA, Tuft RA, Fogarty KE, Pazour GJ |title=The Intraflagellar Transport Protein IFT20 Is Associated with the Golgi Complex and Is Required for Cilia Assembly |journal=Mol. Biol. Cell |volume=17 |issue= 9 |pages= 3781–92 |year= 2006 |pmid= 16775004 |doi= 10.1091/mbc.E06-02-0133 | pmc=1593158 }}
4. ^{{cite journal|last=Sironen|first=Anu|author2=Hanse, J. |author3=Thomsen, B. |author4=Andersson, M. |author5=Vilkki, J. |author6=Toppari, J. |author7=Kotaja, N |title=Expression of SPEF2 During Mouse Spermatogenesis and Identification of IFT20 as an Interacting Protein|journal=Biology of Reproduction|year=2010|volume=82|issue=3|pages=580–590|doi=10.1095/biolreprod.108.074971|pmid=19889948}}

Further reading

{{cite journal | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |name-list-format=vanc| author2=Wentland MA | author3=Ricafrente JY | display-authors=3 | last4=Liu | first4=W | last5=Gibbs | first5=RA }}

{{cite journal | author=Yu W |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |name-list-format=vanc| author2=Andersson B | author3=Worley KC | display-authors=3 | last4=Muzny | first4=DM | last5=Ding | first5=Y | last6=Liu | first6=W | last7=Ricafrente | first7=JY | last8=Wentland | first8=MA | last9=Lennon | first9=G }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Baker SA |title=IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34211–8 |year= 2003 |pmid= 12821668 |doi= 10.1074/jbc.M300156200 |name-list-format=vanc| author2=Freeman K | author3=Luby-Phelps K | display-authors=3 | last4=Pazour | first4=GJ | last5=Besharse | first5=JC }}

{{cite journal | author=Jurczyk A |title=Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly |journal=J. Cell Biol. |volume=166 |issue= 5 |pages= 637–43 |year= 2004 |pmid= 15337773 |doi= 10.1083/jcb.200405023 | pmc=2172416 |name-list-format=vanc| author2=Gromley A | author3=Redick S | display-authors=3 | last4=San Agustin | first4=J | last5=Witman | first5=G | last6=Pazour | first6=GJ | last7=Peters | first7=DJ | last8=Doxsey | first8=S }}

{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija }}