| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the IL36B gene.[1][2][3][4] Function The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[4] References1. ^{{cite journal |vauthors=Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE | title = Four new members expand the interleukin-1 superfamily | journal = J Biol Chem | volume = 275 | issue = 2 | pages = 1169–75 |date=Feb 2000 | pmid = 10625660 | pmc = | doi =10.1074/jbc.275.2.1169 }}
2. ^{{cite journal |vauthors=Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE | title = IL1HY1: A novel interleukin-1 receptor antagonist gene | journal = Biochem Biophys Res Commun | volume = 263 | issue = 3 | pages = 702–6 |date=Nov 1999 | pmid = 10512743 | pmc = | doi = 10.1006/bbrc.1999.1440 }}
3. ^{{cite journal |vauthors=Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne PA, Nicklin MJ, Gabay C | title = The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes | journal = Arthritis Research & Therapy | volume = 8 | issue = 3 | pages = R80 |date=Jun 2006 | pmid = 16646978 | pmc = 1526623 | doi = 10.1186/ar1946 }}
4. ^1 {{cite web | title = Entrez Gene: IL1F8 interleukin 1 family, member 8 (eta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27177| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Nicklin MJ, Weith A, Duff GW |title=A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes |journal=Genomics |volume=19 |issue= 2 |pages= 382–4 |year= 1994 |pmid= 8188271 |doi= 10.1006/geno.1994.1076 }}
- {{cite journal |vauthors=Nothwang HG, Strahm B, Denich D, etal |title=Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13 |journal=Genomics |volume=41 |issue= 3 |pages= 370–8 |year= 1997 |pmid= 9169134 |doi= 10.1006/geno.1997.4654 }}
- {{cite journal |vauthors=Kumar S, McDonnell PC, Lehr R, etal |title=Identification and initial characterization of four novel members of the interleukin-1 family |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10308–14 |year= 2000 |pmid= 10744718 |doi=10.1074/jbc.275.14.10308 }}
- {{cite journal |vauthors=Busfield SJ, Comrack CA, Yu G, etal |title=Identification and gene organization of three novel members of the IL-1 family on human chromosome 2 |journal=Genomics |volume=66 |issue= 2 |pages= 213–6 |year= 2000 |pmid= 10860666 |doi= 10.1006/geno.2000.6184 }}
- {{cite journal |vauthors=Barton JL, Herbst R, Bosisio D, etal |title=A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities |journal=Eur. J. Immunol. |volume=30 |issue= 11 |pages= 3299–308 |year= 2001 |pmid= 11093146 |doi=10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S }}
- {{cite journal |vauthors=Pan G, Risser P, Mao W, etal |title=IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp |journal=Cytokine |volume=13 |issue= 1 |pages= 1–7 |year= 2001 |pmid= 11145836 |doi= 10.1006/cyto.2000.0799 }}
- {{cite journal |vauthors=Lin H, Ho AS, Haley-Vicente D, etal |title=Cloning and characterization of IL-1HY2, a novel interleukin-1 family member |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20597–602 |year= 2001 |pmid= 11278614 |doi= 10.1074/jbc.M010095200 }}
- {{cite journal |vauthors=Debets R, Timans JC, Homey B, etal |title=Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2 |journal=J. Immunol. |volume=167 |issue= 3 |pages= 1440–6 |year= 2001 |pmid= 11466363 |doi= 10.4049/jimmunol.167.3.1440}}
- {{cite journal |vauthors=Sims JE, Nicklin MJ, Bazan JF, etal |title=A new nomenclature for IL-1-family genes |journal=Trends Immunol. |volume=22 |issue= 10 |pages= 536–7 |year= 2001 |pmid= 11574262 |doi=10.1016/S1471-4906(01)02040-3 }}
- {{cite journal |vauthors=Nicklin MJ, Barton JL, Nguyen M, etal |title=A sequence-based map of the nine genes of the human interleukin-1 cluster |journal=Genomics |volume=79 |issue= 5 |pages= 718–25 |year= 2002 |pmid= 11991722 |doi= 10.1006/geno.2002.6751 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Towne JE, Garka KE, Renshaw BR, etal |title=Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13677–88 |year= 2004 |pmid= 14734551 |doi= 10.1074/jbc.M400117200 }}
- {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
{{refend}}{{Cytokines}}{{Interleukin receptor modulators}}{{gene-2-stub}} |