| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.[1]{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.[1]
}}InteractionsILKAP has been shown to interact with Integrin-linked kinase.[2] References1. ^1 {{cite web | title = Entrez Gene: ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80895| accessdate = }}
2. ^{{cite journal |last=Leung-Hagesteijn |first=C |authorlink= |author2=Mahendra A |author3=Naruszewicz I |author4=Hannigan G E |date=May 2001 |title=Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1 |journal=EMBO J. |volume=20 |issue=9 |pages=2160–70 |publisher= |location = England| issn = 0261-4189| pmid = 11331582 |doi = 10.1093/emboj/20.9.2160 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=125446 }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Tong Y, Quirion R, Shen SH |title=Cloning and characterization of a novel mammalian PP2C isozyme |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 35282–90 |year= 1999 |pmid= 9857069 |doi=10.1074/jbc.273.52.35282 }}
- {{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }}
- {{cite journal |vauthors=Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE |title=Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1 |journal=EMBO J. |volume=20 |issue= 9 |pages= 2160–70 |year= 2001 |pmid= 11331582 |doi= 10.1093/emboj/20.9.2160 | pmc=125446 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Kumar AS, Naruszewicz I, Wang P, etal |title=ILKAP regulates ILK signaling and inhibits anchorage-independent growth |journal=Oncogene |volume=23 |issue= 19 |pages= 3454–61 |year= 2004 |pmid= 14990992 |doi= 10.1038/sj.onc.1207473 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
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