“Immunoglobulin I-set domain”的意思、由来-开放百科全书

词条

Immunoglobulin I-set domain

释义

Human proteins containing this domain
References

{{Orphan|date=June 2016}}{{Pfam box
| Symbol = I-set
| Name = Immunoglobulin I-set domain
| image = PDB 1evt EBI.jpg
| width =
| caption = Structures of fibroblast growth factor 1.^[1]
| Pfam= PF07679
| InterPro= IPR013098
| SMART=
| Prosite =
| SCOP =
| TCDB =
| OPM family=
| OPM protein=
| PDB= {{PDB3|1bih}}B:327-412 {{PDB3|1cs6}}A:322-407 {{PDB3|1cvs}}C:159-247 {{PDB3|1epf}}B:20-114 {{PDB3|1evt}}D:159-247 {{PDB3|1fhg}}A:42-132 {{PDB3|1fq9}}C:159-247 {{PDB3|1gxe}}A:652-767 {{PDB3|1ie5}}A:214-304 {{PDB3|1ij9}}A:25-112 {{PDB3|1koa}}:6585-6674 {{PDB3|1pd6}}A:363-448 {{PDB3|1qct}}E:153-241 {{PDB3|1qz1}}A:214-305 {{PDB3|1ry7}}B:157-245 {{PDB3|1tlk}}:42-132 {{PDB3|1tnm}}:33489-3357 {{PDB3|1tnn}}:33489-3357 {{PDB3|1u2h}}A:43-113 {{PDB3|1vca}}A:25-112 {{PDB3|1vsc}}A:25-112 {{PDB3|1wf5}}A:306-320 {{PDB3|1wit}}:4150-4239 {{PDB3|1wiu}}:4150-4239 {{PDB3|1wwc}}A:325-352 {{PDB3|1x44}}A:342-430 {{PDB3|2cqv}}A:1238-1327 {{PDB3|2cry}}A:419-516 {{PDB3|2ncm}}:20-114
}}I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM). I-set domains are also present in several other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1,^[2] and the signalling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.^[3]

Human proteins containing this domain

ADAMTSL1, ADAMTSL3, ALPK3, AXL,
BOC,
C9orf94, CADM2, CADM4, CCDC141, CDON, CEACAM7, CHL1, CILP2, CNTN1, CNTN2, CNTN3, CNTN4, CNTN5, CNTN6, CXADR,
DCC, DSCAM, DSCAML1,
ESAM,
FGFR1, FGFR3, FGFR4, FGFRL1, FLT1, FLT4, FSTL4, FSTL5,
HMCN1, HNT, HSPG2,
ICAM5, IGFBP7, IGFBPL1, IGSF10, IGSF22, IGSF9, ISLR,
KALRN, KAZALD1, KDR, KIAA0626, KIRREL, KIRREL2, KIRREL3,
L1CAM, LINGO1, LINGO2, LRFN2, LRFN3, LRFN4, LRFN5, LRIG1, LRIG2, LRIG3, LRIT2, LRIT3, LRRC24, LRRC4B, LRRC4C, LRRN1, LRRN3, LRRN5, LSAMP,
MAG, MDGA2, MFAP3L, MUSK, MXRA5, MYBPC1, MYBPC2, MYBPC3, MYBPH, MYBPHL, MYLK, MYOM1, MYOM2, MYOM3, MYOT, MYPN,
NCAM1, NCAM2, NEGR1, NEO1, NEXN, NFASC, NGL1, NOPE, NPHS1, NPTN, NRCAM, NRG2, NT, NTRK2, NTRK3,
OBSCN, OBSL1, OPCML,
PALLD, PAPLN, PDGFRA, PRODH2, PTK7, PTPRD, PTPRF, PTPRS, PTPsigma, PUNC,
ROBO1, ROBO2, ROBO3, ROBO4, ROR1, ROR2,
SDK1, SDK2, SIGLEC1, SIGLEC6, SPEG,
TRIO, TTN,
UNC5A, UNC5B, UNC5C,
VCAM1, WFIKKN1, WFIKKN2,

References

1. ^{{cite journal |vauthors=Plotnikov AN, Hubbard SR, Schlessinger J, Mohammadi M |title=Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity |journal=Cell |volume=101 |issue=4 |pages=413–24 |date=May 2000 |pmid=10830168 |doi= 10.1016/S0092-8674(00)80851-X|url=}}
2. ^{{cite journal |vauthors=Sonderegger P, Welte W, Diederichs K, Freigang J, Proba K, Leder L |title=The crystal structure of the ligand binding module of axonin-1/TAG-1 suggests a zipper mechanism for neural cell adhesion |journal=Cell |volume=101 |issue=4 |pages=425–33 |year=2000 |pmid=10830169 |doi=10.1016/S0092-8674(00)80852-1}}
3. ^{{cite journal |vauthors=Stuart DI, Jones EY, Harlos K, Esnouf RM, Love CA |title=Structure determination of human semaphorin 4D as an example of the use of MAD in non-optimal cases |journal=Acta Crystallogr. D |volume=62 |issue= Pt 1|pages=108–15 |year=2006 |pmid=16369100 |doi=10.1107/S0907444905034992}}

2 : Protein domains|Single-pass transmembrane proteins

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