| 释义 |
- Function
- Clinical significance
- See also
- References
- Further reading
{{Infobox_gene}}Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene.[1][2][3] Function IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. IMPDH2 catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate.[1] IMPDH2 has been identified as an intracellular target of the natural product sanglifehrin A[4] Clinical significance This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.[1] See also References1. ^1 2 {{cite web | title = Entrez Gene: IMP (inosine monophosphate) dehydrogenase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3615| accessdate = }}
2. ^{{cite journal |vauthors=Natsumeda Y, Ohno S, Kawasaki H, Konno Y, Weber G, Suzuki K | title = Two distinct cDNAs for human IMP dehydrogenase | journal = J. Biol. Chem. | volume = 265 | issue = 9 | pages = 5292–5 |date=March 1990 | pmid = 1969416 | doi = | url = | issn = }}
3. ^{{cite journal |vauthors=Kost-Alimova MV, Glesne DA, Huberman E, Zelenin AV | title = Assignment1 of inosine '-monophosphate dehydrogenase type 2 (IMPDH2) to human chromosome band 3p21.2 by in situ hybridization | journal = Cytogenet. Cell Genet. | volume = 82 | issue = 3–4 | pages = 145–6 | year = 1998 | pmid = 9858805 | doi = 10.1159/000015088| url = | issn = }}
4. ^{{cite journal |vauthors=Pua KH, Stiles DT, Sowa ME, Verdine GL | title = IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex | journal = Cell Rep. | volume = 18 | issue = 2 | pages = 432-442 |date=10 January 2017 | pmid = 28076787 | doi = 10.1016/j.celrep.2016.12.030 | url = | issn = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Garat A, Cauffiez C, Hamdan-Khalil R, etal |title=IMPDH2 genetic polymorphism: a promoter single-nucleotide polymorphism disrupts a cyclic adenosine monophosphate responsive element |journal=Genet Test Mol Biomarkers |volume=13 |issue= 6 |pages= 841–7 |year= 2009 |pmid= 19810816 |doi= 10.1089/gtmb.2009.0096 }}
- {{cite journal |vauthors=Wang J, Zeevi A, Webber S, etal |title=A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity |journal=Pharmacogenet. Genomics |volume=17 |issue= 4 |pages= 283–90 |year= 2007 |pmid= 17496727 |doi= 10.1097/FPC.0b013e328012b8cf }}
- {{cite journal |vauthors=So HC, Fong PY, Chen RY, etal |title=Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=153B |issue= 1 |pages= 103–13 |year= 2010 |pmid= 19367581 |doi= 10.1002/ajmg.b.30961 }}
- {{cite journal |vauthors=Grinyó J, Vanrenterghem Y, Nashan B |title=Association of four DNA polymorphisms with acute rejection after kidney transplantation |journal=Transpl. Int. |volume=21 |issue= 9 |pages= 879–91 |year= 2008 |pmid= 18444945 |doi= 10.1111/j.1432-2277.2008.00679.x |display-authors=etal}}
- {{cite journal |vauthors=Ohmann EL, Burckart GJ, Brooks MM, etal |title=Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients |journal=The Journal of Heart and Lung Transplantation |volume= 29|issue= 5|pages= HASH(0x2dc9fd0) |year= 2010 |pmid= 20061166 |doi= 10.1016/j.healun.2009.11.602 }}
- {{cite journal |vauthors=Sombogaard F, van Schaik RH, Mathot RA, etal |title=Interpatient variability in IMPDH activity in MMF-treated renal transplant patients is correlated with IMPDH type II 3757T > C polymorphism |journal=Pharmacogenet. Genomics |volume=19 |issue= 8 |pages= 626–34 |year= 2009 |pmid= 19617864 |doi= 10.1097/FPC.0b013e32832f5f1b }}
- {{cite journal |vauthors=Fellenberg J, Bernd L, Delling G, etal |title=Prognostic significance of drug-regulated genes in high-grade osteosarcoma |journal=Mod. Pathol. |volume=20 |issue= 10 |pages= 1085–94 |year= 2007 |pmid= 17660802 |doi= 10.1038/modpathol.3800937 }}
- {{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
- {{cite journal |vauthors=He Y, Mou Z, Li W, etal |title=Identification of IMPDH2 as a tumor-associated antigen in colorectal cancer using immunoproteomics analysis |journal=Int J Colorectal Dis |volume=24 |issue= 11 |pages= 1271–9 |year= 2009 |pmid= 19597826 |doi= 10.1007/s00384-009-0759-2 }}
- {{cite journal |vauthors=Peñuelas S, Noé V, Ciudad CJ |title=Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells |journal=FEBS J. |volume=272 |issue= 3 |pages= 696–710 |year= 2005 |pmid= 15670151 |doi= 10.1111/j.1742-4658.2004.04504.x }}
- {{cite journal |vauthors=Winnicki W, Weigel G, Sunder-Plassmann G, etal |title=An inosine 5'-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of mycophenolic acid |journal=Pharmacogenomics J. |volume=10 |issue= 1 |pages= 70–6 |year= 2010 |pmid= 19770842 |doi= 10.1038/tpj.2009.43 }}
- {{cite journal |vauthors=Patel CG, Richman K, Yang D, etal |title=Effect of diabetes mellitus on mycophenolate sodium pharmacokinetics and inosine monophosphate dehydrogenase activity in stable kidney transplant recipients |journal=Ther Drug Monit |volume=29 |issue= 6 |pages= 735–42 |year= 2007 |pmid= 18043470 |doi= 10.1097/FTD.0b013e31815d8ace |pmc=4082794 }}
- {{cite journal |vauthors=Sanquer S, Maison P, Tomkiewicz C, etal |title=Expression of inosine monophosphate dehydrogenase type I and type II after mycophenolate mofetil treatment: a 2-year follow-up in kidney transplantation |journal=Clin. Pharmacol. Ther. |volume=83 |issue= 2 |pages= 328–35 |year= 2008 |pmid= 17713475 |doi= 10.1038/sj.clpt.6100300 }}
- {{cite journal |vauthors=Mohamed MF, Frye RF, Langaee TY |title=Interpopulation variation frequency of human inosine 5'-monophosphate dehydrogenase type II (IMPDH2) genetic polymorphisms |journal=Genet. Test. |volume=12 |issue= 4 |pages= 513–6 |year= 2008 |pmid= 18976158 |doi= 10.1089/gte.2008.0049 }}
- {{cite journal |vauthors=Mannava S, Grachtchouk V, Wheeler LJ, etal |title=Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells |journal=Cell Cycle |volume=7 |issue= 15 |pages= 2392–400 |year= 2008 |pmid= 18677108 |doi= 10.4161/cc.6390|pmc=3744895 }}
- {{cite journal |vauthors=Chen L, Petrelli R, Olesiak M, etal |title=Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase |journal=Bioorg. Med. Chem. |volume=16 |issue= 15 |pages= 7462–9 |year= 2008 |pmid= 18583139 |doi= 10.1016/j.bmc.2008.06.003 }}
- {{cite journal |vauthors=Guo D, Han J, Adam BL, etal |title=Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1308–18 |year= 2005 |pmid= 16236267 |doi= 10.1016/j.bbrc.2005.09.191 }}
- {{cite journal |vauthors=Kudo M, Saito Y, Sasaki T, etal |title=Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals |journal=Drug Metab. Pharmacokinet. |volume=24 |issue= 6 |pages= 557–64 |year= 2009 |pmid= 20045992 |doi= 10.2133/dmpk.24.557}}
- {{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 |pmc=1847948}}
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