| 词条 | Indium-111 |
| 释义 |
| alternate_names = | symbol =In | mass_number =111 | mass = | num_neutrons =62 | num_protons =49 | abundance = syn | halflife = 2.8049 d[1] | error_halflife = | background = | text_color = | image = | image_caption = image caption | decay_product = cadmium-111 | decay_symbol = Cd | decay_mass = 111 | decay_mode1 = EC | decay_halflife1 = | decay_intensity1 = | decay_energy1 = 0.860[2] | decay_mode2 = | decay_halflife2 = | decay_intensity2 = | decay_energy2 = | decay_mode3 = | decay_halflife3 = | decay_intensity3 = | decay_energy3 = | decay_mode4 = | decay_halflife4 = | decay_intensity4 = | decay_energy4 = | parent = | parent_symbol = | parent_mass = | parent_decay = | parent2 = | parent2_symbol = | parent2_mass = | parent2_decay = | spin = | excess_energy = | error1 = | nuclear binding_energy = | error2 = }} Indium-111 (111In) is a radioactive isotope of indium (In). It decays by electron capture to cadmium-111 with a half-life of 2.8 days. 111In chloride (Cl) solution is produced by proton irradiation ((p,2n) of a cadmium (Cd) isotope (112Cd) OR (p,n) 111Cd enriched target) in a cyclotron, as recommended by International Atomic Energy Agency (IAEA).[3] The former method is more commonly used as is results in a high level of radionuclide purity. 111In has a half-life (t1/2) of 2.81 days (67.32 hours) decaying by electron capture (EC) to 111Cd, which is stable (non-radioactive).[4]It is commonly in Nuclear Medicine Diagnostic Imaging by radio-labeling targeted molecules or cells, During its radioactive decay, it emits low energy gamma (γ) photons which can be imaged using planar or SPECT (Single Photon Emission Computed Tomography) gamma cameras (primary energies (ε) of 171.3 keV (91%) and 245.4 keV (94%) )[4] Examples of uses in nuclear medicineWhen formulated as an 111In Cl solution, it can be used to bind antibodies or other molecular targeted proteins or other molecules, typically using a chelate to bind the radionuclide (in this case 111In) to the targeting molecule during the radiosynthesis/ radiolabeling process, which is tailored to the desired product. 111In labeled antibodies
111In labeled peptides
111In can also be formulated in the chemical form 111In oxyquinoline (oxine)[5] for labeling blood cells and components
See also
References1. ^{{cite book|title=Table of Radionuclides, Vol. 3|date=2006|publisher=Bureau international des poids et mesures|isbn=92-822-2218-7|page=75|url=http://www.nucleide.org/DDEP_WG/Nuclides/In-111_tables.pdf|accessdate=26 June 2017}} {{Radiopharmaceuticals}}2. ^{{NUBASE 2016 II}} 3. ^{{Cite journal|last=Takács|first=S.|last2=Tárkányi|first2=F.|last3=Hermanne|first3=A.|date=Dec 2005|title=Validation and upgrading of the recommended cross-section data of charged particle reactions: Gamma emitter radioisotopes|url=http://linkinghub.elsevier.com/retrieve/pii/S0168583X05011547|journal=Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms|volume=240|issue=4|pages=790–802|doi=10.1016/j.nimb.2005.06.209|issn=0168-583X|via=}} 4. ^1 {{Cite web|url=https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=019841|title=FDA Label Document:Indium In-111 Chloride Sterile Solution|last=|first=|date=|website=www.accessdata.fda.gov|archive-url=|archive-date=|dead-url=|access-date=20 Aug 2018}} 5. ^{{Cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/119117#section=3D-Conformer|title=PubChem In-111 Oxyquinoline|last=|first=|date=|website=pubchem.ncbi.nlm.nih.gov|archive-url=|archive-date=|dead-url=|access-date=20 Aug 2018}} 6. ^{{cite web|title=IN-111 FACT SHEET|url=http://www.nordion.com/documents/products/In-111_Can.pdf|publisher=Nordion(Canada), Inc.|accessdate=23 September 2012|deadurl=yes|archiveurl=https://web.archive.org/web/20111203082605/http://www.nordion.com/documents/products/In-111_Can.pdf|archivedate=3 December 2011|df=}} 1 : Isotopes of indium |
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