“Influenza non-structural protein”的意思、由来-开放百科全书

词条

Influenza non-structural protein

释义

References

{{Pfam box |Symbol = Flu_NS1 |Name = Influenza non-structural protein (NS1) |Pfam = PF00600 |InterPro = IPR000256 |PROSITE = |PDB = {{PDB|1ail}} {{PDB|1ns1}} }}Influenza non-structural protein (NS1) is a homodimeric RNA-binding protein found in influenza virus that is required for viral replication. NS1 binds polyA tails of mRNA keeping them in the nucleus. NS1 inhibits pre-mRNA splicing by tightly binding to a specific stem-bulge of U6 snRNA.^[1]

References

1. ^{{cite journal |vauthors=Huang Y, Rios CB, Tejero R, Zimmerman DE, Krug RM, Montelione GT, Chien CY |title=A novel RNA-binding motif in influenza A virus non-structural protein 1 |journal=Nat. Struct. Biol. |volume=4 |issue=11 |pages=891–895 |year=1997 |pmid=9360601 |doi=10.1038/nsb1197-891}}

1 : Protein domains

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