| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.[1][2][3] Function Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.[3] [4] Interactions INSM1 has been shown to interact with SORBS1.[5] References 1. ^{{cite journal | vauthors = Lan MS, Li Q, Lu J, Modi WS, Notkins AL | title = Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1 | journal = The Journal of Biological Chemistry | volume = 269 | issue = 19 | pages = 14170–4 | date = May 1994 | pmid = 8188699 | pmc = | doi = }}
2. ^{{cite journal | vauthors = Liu WD, Wang HW, Muguira M, Breslin MB, Lan MS | title = INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases | journal = The Biochemical Journal | volume = 397 | issue = 1 | pages = 169–77 | date = July 2006 | pmid = 16569215 | pmc = 1479746 | doi = 10.1042/BJ20051669 }}
3. ^1 {{cite web | title = Entrez Gene: INSM1 insulinoma-associated 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3642| access-date = }}
4. ^{{cite journal | vauthors = Mukhopadhyay S, Dermawan JK, Lanigan CP, Farver CF | title = Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections | journal = Modern Pathology | volume = Epub ahead of print | date = August 2018 | pmid = 30154579 | doi = 10.1038/s41379-018-0122-7 }}
5. ^{{cite journal | vauthors = Xie J, Cai T, Zhang H, Lan MS, Notkins AL | title = The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein | journal = Genomics | volume = 80 | issue = 1 | pages = 54–61 | date = July 2002 | pmid = 12079283 | pmc = 1237014 | doi = 10.1006/geno.2002.6800 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Goto Y, De Silva MG, Toscani A, Prabhakar BS, Notkins AL, Lan MS | title = A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs | journal = The Journal of Biological Chemistry | volume = 267 | issue = 21 | pages = 15252–7 | date = July 1992 | pmid = 1634555 | doi = }}
- {{cite journal | vauthors = Li Q, Notkins AL, Lan MS | title = Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1 | journal = Biochemical and Biophysical Research Communications | volume = 236 | issue = 3 | pages = 776–81 | date = July 1997 | pmid = 9245732 | doi = 10.1006/bbrc.1997.7054 }}
- {{cite journal | vauthors = Breslin MB, Zhu M, Notkins AL, Lan MS | title = Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence | journal = Nucleic Acids Research | volume = 30 | issue = 4 | pages = 1038–45 | date = February 2002 | pmid = 11842116 | pmc = 100352 | doi = 10.1093/nar/30.4.1038 }}
- {{cite journal | vauthors = Zhu M, Breslin MB, Lan MS | title = Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells | journal = Pancreas | volume = 24 | issue = 2 | pages = 139–45 | date = March 2002 | pmid = 11854618 | doi = 10.1097/00006676-200203000-00004 }}
- {{cite journal | vauthors = Xie J, Cai T, Zhang H, Lan MS, Notkins AL | title = The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein | journal = Genomics | volume = 80 | issue = 1 | pages = 54–61 | date = July 2002 | pmid = 12079283 | pmc = 1237014 | doi = 10.1006/geno.2002.6800 }}
- {{cite journal | vauthors = Breslin MB, Zhu M, Lan MS | title = NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system | journal = The Journal of Biological Chemistry | volume = 278 | issue = 40 | pages = 38991–7 | date = October 2003 | pmid = 12890672 | pmc = 1236987 | doi = 10.1074/jbc.M306795200 }}
- {{cite journal | vauthors = Zhang T, Liu WD, Saunee NA, Breslin MB, Lan MS | title = Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest | journal = The Journal of Biological Chemistry | volume = 284 | issue = 9 | pages = 5574–81 | date = February 2009 | pmid = 19124461 | pmc = 2645817 | doi = 10.1074/jbc.M808843200 }}
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