| 释义 |
- Function
- Related gene problems
- References
- Further reading
- External links
{{Infobox_gene}}Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene.[1][2][3]FunctionIntegrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue.[1]Related gene problems- TAR syndrome[4]
- 1q21.1 deletion syndrome
- 1q21.1 duplication syndrome
References1. ^1 {{cite web | title = Entrez Gene: ITGA10 integrin, alpha 10 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8515 | accessdate = }}
2. ^{{cite journal |vauthors=Camper L, Hellman U, Lundgren-Akerlund E | title = Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes | journal = J. Biol. Chem. | volume = 273 | issue = 32 | pages = 20383–9 |date=August 1998 | pmid = 9685391 | doi = 10.1074/jbc.273.32.20383| url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=9685391 }}
3. ^{{cite journal |vauthors=Lehnert K, Ni J, Leung E, Gough S, Morris CM, Liu D, Wang SX, Langley R, Krissansen GW | title = The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization | journal = Cytogenet. Cell Genet. | volume = 87 | issue = 3–4 | pages = 238–44 | year = 1999 | pmid = 10702680 | doi = 10.1159/000015434| url = http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=ccg87238 }}
4. ^{{cite journal |vauthors=Klopocki E, Schulze H, Strauss G, etal | title = Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome | journal = Am. J. Hum. Genet. | volume = 80 | issue = 2 | pages = 232–40 |date=February 2007 | pmid = 17236129 | pmc = 1785342 | doi = 10.1086/510919 | url = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Camper L, Hellman U, Lundgren-Akerlund E |title=Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20383–9 |year= 1998 |pmid= 9685391 |doi= 10.1074/jbc.273.32.20383}}
- {{cite journal |vauthors=Bengtsson T, Camper L, Schneller M, Lundgren-Akerlund E |title=Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants |journal=Matrix Biol. |volume=20 |issue= 8 |pages= 565–76 |year= 2001 |pmid= 11731273 |doi= 10.1016/S0945-053X(01)00164-0}}
- {{cite journal |vauthors=Brakebusch C, Hirsch E, Potocnik A, Fässler R |title=Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules |journal=J. Cell Sci. |volume=110 |issue= 23|pages= 2895–904 |year= 1997 |pmid= 9359872 |doi= }}
- {{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 |pmc=403697}}
- {{cite journal |vauthors=Lehnert K, Ni J, Leung E, etal |title=The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3–4 |pages= 238–44 |year= 1999 |pmid= 10702680 |doi= 10.1159/000015434}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241}}
- {{cite journal |author=Svoboda KK |title=Chondrocyte-matrix attachment complexes mediate survival and differentiation |journal=Microsc. Res. Tech. |volume=43 |issue= 2 |pages= 111–22 |year= 1998 |pmid= 9822998 |doi= 10.1002/(SICI)1097-0029(19981015)43:2<111::AID-JEMT4>3.0.CO;2-O }}
- {{cite journal |vauthors=Bengtsson T, Aszodi A, Nicolae C, etal |title=Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes |journal=J. Cell Sci. |volume=118 |issue= Pt 5 |pages= 929–36 |year= 2005 |pmid= 15713743 |doi= 10.1242/jcs.01678 }}
- {{cite journal |vauthors=Wenke AK, Rothhammer T, Moser M, Bosserhoff AK |title=Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1 |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 1 |pages= 495–501 |year= 2006 |pmid= 16684505 |doi= 10.1016/j.bbrc.2006.04.123 }}
{{refend}}External links- ITGA10 Info with links in the Cell Migration Gateway
{{NLM content}}{{Integrins}}{{gene-1-stub}} 1 : Integrins |