| 释义 |
- Function
- Clinical significance
- References
- Further reading
- External links
{{Infobox_gene}}Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene.[1] Function This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[1] Additionally, it has been shown to interact with RhoGDI1 to alter the activation of Rho GTPases to promote Glioblastoma cell invasiveness. Uncoupling the αvβ8-RhoGDI1 interaction has been seen to block GBM cell invasion by hyperactivating Rho GTPases.[2] Clinical significance High expression levels of ITGB8 are associated with high angiogenic and poorly invasive glioblastoma tumors. Conversely low expression of ITGB8 correlates with highly invasive but low angiogenic tumors.[3] References1. ^1 {{cite web | title = Entrez Gene: ITGB8 integrin, beta 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3696| accessdate = }}
2. ^{{cite journal |vauthors=Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH | title = αvβ8 Integrin Interacts with RhoGDI1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion | journal = Mol Biol Cell |date=January 2012 | pmid = 23283986 | doi=10.1091/mbc.E12-07-0521 | volume=24 | issue=4 | pages=474–82| pmc=3571870 }}
3. ^{{cite journal |vauthors=Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH | title = Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by {beta}8 Integrin | journal = Cancer Res. | volume = 71 | issue = 20 | pages = 6371–81 | year =October 2011 | month = | pmid = 21859829 | doi = 10.1158/0008-5472.CAN-11-0991 | pmc=3193578}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Moyle M, Napier MA, McLean JW |title=Cloning and expression of a divergent integrin subunit beta 8. |journal=J. Biol. Chem. |volume=266 |issue= 29 |pages= 19650–8 |year= 1991 |pmid= 1918072 |doi= }}
- {{cite journal |vauthors=Nishimura SL, Sheppard D, Pytela R |title=Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. |journal=J. Biol. Chem. |volume=269 |issue= 46 |pages= 28708–15 |year= 1994 |pmid= 7525578 |doi= }}
- {{cite journal |vauthors=Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM |title=Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo. |journal=Am. J. Physiol. |volume=273 |issue= 1 Pt 1 |pages= L256–63 |year= 1997 |pmid= 9252563 |doi= 10.1152/ajplung.1997.273.1.L256}}
- {{cite journal |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097|last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The }}
- {{cite journal |vauthors=Cambier S, Mu DZ, O'Connell D, etal |title=A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth. |journal=Cancer Res. |volume=60 |issue= 24 |pages= 7084–93 |year= 2001 |pmid= 11156415 |doi= }}
- {{cite journal |vauthors=Mu D, Cambier S, Fjellbirkeland L, etal |title=The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1 |journal=J. Cell Biol. |volume=157 |issue= 3 |pages= 493–507 |year= 2002 |pmid= 11970960 |doi= 10.1083/jcb.200109100 | pmc=2173277 }}
- {{cite journal |vauthors=Jarad G, Wang B, Khan S, etal |title=Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47826–33 |year= 2003 |pmid= 12324452 |doi= 10.1074/jbc.M204901200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 }}
- {{cite journal |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
- {{cite journal |vauthors=Fjellbirkeland L, Cambier S, Broaddus VC, etal |title=Integrin αvβ8-Mediated Activation of Transforming Growth Factor-β Inhibits Human Airway Epithelial Proliferation in Intact Bronchial Tissue |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 533–42 |year= 2003 |pmid= 12875973 |doi= 10.1016/S0002-9440(10)63681-4| pmc=1868219 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
- {{cite journal |vauthors=Yan W, Shao R |title=Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation |journal=J. Biol. Chem. |volume=281 |issue= 28 |pages= 19700–8 |year= 2006 |pmid= 16702213 |doi= 10.1074/jbc.M601856200 }}
{{refend}}External links- ITGB8 Info with links in the Cell Migration Gateway
{{Integrins}}{{gene-7-stub}} 1 : Integrins |