| 释义 |
- References
- Further reading
{{Infobox_gene}}Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene.[1]IL10RB has also recently been designated CDW210B (cluster of differentiation W210B). The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.[2] References1. ^{{cite web | title = Entrez Gene: IL10RB interleukin 10 receptor, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3588| accessdate = }}
2. ^{{cite web | title = Entrez Gene: IL10RB interleukin 10 receptor, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3588| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Lutfalla G, McInnis MG, Antonarakis SE, Uzé G |title=Structure of the human CRFB4 gene: comparison with its IFNAR neighbor. |journal=J. Mol. Evol. |volume=41 |issue= 3 |pages= 338–44 |year= 1995 |pmid= 7563119 |doi=10.1007/BF01215180 }}
- {{cite journal |vauthors=Lutfalla G, Gardiner K, Uzé G |title=A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. |journal=Genomics |volume=16 |issue= 2 |pages= 366–73 |year= 1993 |pmid= 8314576 |doi= 10.1006/geno.1993.1199 }}
- {{cite journal |vauthors=Gibbs VC, Pennica D |title=CRF2-4: isolation of cDNA clones encoding the human and mouse proteins. |journal=Gene |volume=186 |issue= 1 |pages= 97–101 |year= 1997 |pmid= 9047351 |doi=10.1016/S0378-1119(96)00690-7 }}
- {{cite journal |vauthors=Kotenko SV, Krause CD, Izotova LS, etal |title=Identification and functional characterization of a second chain of the interleukin-10 receptor complex. |journal=EMBO J. |volume=16 |issue= 19 |pages= 5894–903 |year= 1997 |pmid= 9312047 |doi= 10.1093/emboj/16.19.5894 | pmc=1170220 }}
- {{cite journal |vauthors=Spencer SD, Di Marco F, Hooley J, etal |title=The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. |journal=J. Exp. Med. |volume=187 |issue= 4 |pages= 571–8 |year= 1998 |pmid= 9463407 |doi=10.1084/jem.187.4.571 | pmc=2212143 }}
- {{cite journal |vauthors=Reboul J, Gardiner K, Monneron D, etal |title=Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster. |journal=Genome Res. |volume=9 |issue= 3 |pages= 242–50 |year= 1999 |pmid= 10077530 |doi= 10.1101/gr.9.3.242| pmc=310731 }}
- {{cite journal |vauthors=Hattori M, Fujiyama A, Taylor TD, etal |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
- {{cite journal |vauthors=Xie MH, Aggarwal S, Ho WH, etal |title=Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31335–9 |year= 2000 |pmid= 10875937 |doi= 10.1074/jbc.M005304200 }}
- {{cite journal |vauthors=Dumoutier L, Van Roost E, Colau D, Renauld JC |title=Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 18 |pages= 10144–9 |year= 2000 |pmid= 10954742 |doi= 10.1073/pnas.170291697 | pmc=27764 }}
- {{cite journal |vauthors=Lewis K, Li C, Perrin MH, etal |title=Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7570–5 |year= 2001 |pmid= 11416224 |doi= 10.1073/pnas.121165198 | pmc=34709 }}
- {{cite journal |vauthors=Hollborn M, Kohen L, Wiedemann P, Enzmann V |title=The influence of pro-inflammatory cytokines on human retinal pigment epithelium cell receptors. |journal=Graefes Arch. Clin. Exp. Ophthalmol. |volume=239 |issue= 4 |pages= 294–301 |year= 2001 |pmid= 11450494 |doi=10.1007/s004170100263 }}
- {{cite journal |vauthors=Josephson K, Logsdon NJ, Walter MR |title=Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. |journal=Immunity |volume=15 |issue= 1 |pages= 35–46 |year= 2001 |pmid= 11485736 |doi=10.1016/S1074-7613(01)00169-8 }}
- {{cite journal |vauthors=Sheppard P, Kindsvogel W, Xu W, etal |title=IL-28, IL-29 and their class II cytokine receptor IL-28R. |journal=Nat. Immunol. |volume=4 |issue= 1 |pages= 63–8 |year= 2003 |pmid= 12469119 |doi= 10.1038/ni873 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Kotenko SV, Gallagher G, Baurin VV, etal |title=IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. |journal=Nat. Immunol. |volume=4 |issue= 1 |pages= 69–77 |year= 2003 |pmid= 12483210 |doi= 10.1038/ni875 }}
- {{cite journal |vauthors=Hör S, Pirzer H, Dumoutier L, etal |title=The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33343–51 |year= 2004 |pmid= 15178681 |doi= 10.1074/jbc.M405000200 }}
- {{cite journal |vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Pletnev S, Magracheva E, Wlodawer A, Zdanov A |title=A model of the ternary complex of interleukin-10 with its soluble receptors. |journal=BMC Struct. Biol. |volume=5|pages= 10 |year= 2006 |pmid= 15985167 |doi= 10.1186/1472-6807-5-10 | pmc=1192808 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
{{refend}}{{NLM content}}{{Clusters of differentiation}}{{Cytokine receptors}}{{Interleukin receptor modulators}}{{membrane-protein-stub}} 2 : Clusters of differentiation|Type II cytokine receptors |