| 词条 | Interleukin-27 receptor |
| 释义 |
| Name = interleukin 27 receptor, alpha | caption = | image = | width = | HGNCid = 17290 | Symbol = IL27RA | AltSymbols = WSX-1, TCCR, CRL1, WSX1, zcytor1, IL-27R | EntrezGene = 9466 | OMIM = 605350 | RefSeq = NM_004843 | UniProt = Q6UWB1 | PDB = | ECnumber = | Chromosome = 19 | Arm = p | Band = 13.11 | LocusSupplementaryData = }}{{infobox protein | Name = interleukin 6 signal transducer (gp130, oncostatin M receptor) | caption = | image = | width = | HGNCid = 6021 | Symbol = IL6ST | AltSymbols = GP130, CD130 | EntrezGene = 3572 | OMIM = 600694 | RefSeq = NM_002184 | UniProt = P40189 | PDB = | ECnumber = | Chromosome = 5 | Arm = q | Band = 11 | LocusSupplementaryData = }} The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit[1][2] and glycoprotein 130.[3] IL27RA essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.[4] References1. ^{{cite journal |vauthors=Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF | title = Cloning and characterization of a novel class I cytokine receptor | journal = Biochem. Biophys. Res. Commun. | volume = 246 | issue = 1 | pages = 82–90 | year = 1998 | pmid = 9600072 | doi = 10.1006/bbrc.1998.8576 }} 2. ^{{cite journal |vauthors=Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ | title = Development of Th1-type immune responses requires the type I cytokine receptor TCCR | journal = Nature | volume = 407 | issue = 6806 | pages = 916–20 | year = 2000 | pmid = 11057672 | doi = 10.1038/35038103 }} 3. ^{{cite journal |vauthors=Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA | title = WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 | journal = Journal of Immunology | volume = 172 | issue = 4 | pages = 2225–31 |date=February 2004 | pmid = 14764690 | doi = 10.4049/jimmunol.172.4.2225| url = http://www.jimmunol.org/cgi/content/abstract/172/4/2225 }} 4. ^{{cite journal |vauthors=Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H | title = Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment | journal = J. Immunol. | volume = 170 | issue = 10 | pages = 4886–90 |date=May 2003 | pmid = 12734330 | doi = 10.4049/jimmunol.170.10.4886| url = http://www.jimmunol.org/cgi/content/abstract/170/10/4886 }} External links
1 : Type I cytokine receptors |
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