| 词条 | Interleukin 34 |
| 释义 |
Interleukin 34 (IL-34) is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening of secreted proteins; chimpanzee, murine, rat and chicken interleukin 34 orthologs have also been found. The protein is composed of 241 amino acids, 39 kilodaltons in mass, and forms homodimers. IL-34 increases growth or survival of immune cells known as monocytes; it elicits its activity by binding the Colony stimulating factor 1 receptor. Messenger RNA (mRNA) expression of human IL-34 is most abundant in spleen but occurs in several other tissues: thymus, liver, small intestine, colon, prostate gland, lung, heart, brain, kidney, testes, and ovary. The discovery of IL-34 protein in the red pulp of the spleen suggests involvement in growth and development of myeloid cells, consistent with its activity on monocytes. [1]References1. ^{{cite journal |vauthors=Lin H, Lee E, Hestir K, etal |title=Discovery of a cytokine and its receptor by functional screening of the extracellular proteome |journal=Science |volume=320 |issue=5877 |pages=807–11 |date=May 2008 |pmid=18467591 |doi=10.1126/science.1154370 |url=}} External links{{MeshName|Interleukin-34}}{{Interleukins}}{{Cytokine receptor modulators}}{{Interleukin receptor modulators}}{{protein-stub}} 2 : Interleukins|Signal transduction |
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