“Interleukin 37”的意思、由来-开放百科全书

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.^[4]

References

1. ^{{cite journal |vauthors=Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE | title = Four new members expand the interleukin-1 superfamily | journal = J Biol Chem | volume = 275 | issue = 2 | pages = 1169–75 |date=Feb 2000 | pmid = 10625660 | pmc = | doi =10.1074/jbc.275.2.1169 }}
2. ^{{cite journal |vauthors=Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE | title = IL1HY1: A novel interleukin-1 receptor antagonist gene | journal = Biochem Biophys Res Commun | volume = 263 | issue = 3 | pages = 702–6 |date=Nov 1999 | pmid = 10512743 | pmc = | doi = 10.1006/bbrc.1999.1440 }}
3. ^{{cite journal |vauthors=Gao W, Kumar S, Lotze MT, Hanning C, Robbins PD, Gambotto A | title = Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity | journal = J Immunol | volume = 170 | issue = 1 | pages = 107–13 |date=Dec 2002 | pmid = 12496389 | pmc = | doi = 10.4049/jimmunol.170.1.107}}
4. ^¹{{cite web | title = Entrez Gene: IL37 interleukin 37| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27178| accessdate = }}

Further reading

{{cite journal |vauthors=Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF |title=IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction |journal=Nature Immunology |volume=16 |issue=4 |pages=354–65 |year=2015 |pmid=25729923 |doi=10.1038/ni.3103 }}

{{cite journal |vauthors=Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P, Dinarello CA |title=IL-37 is a fundamental inhibitor of innate immunity |journal=Nature Immunology |volume=11 |issue=11 |pages=1014–22 |year=2010 |pmid=20935647 |pmc=3537119 |doi=10.1038/ni.1944 }}

{{cite journal |vauthors=Nicklin MJ, Weith A, Duff GW |title=A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes |journal=Genomics |volume=19 |issue= 2 |pages= 382–4 |year= 1994 |pmid= 8188271 |doi= 10.1006/geno.1994.1076 }}

{{cite journal | author=Nothwang HG |title=Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13 |journal=Genomics |volume=41 |issue= 3 |pages= 370–8 |year= 1997 |pmid= 9169134 |doi= 10.1006/geno.1997.4654 |name-list-format=vanc| author2=Strahm B | author3=Denich D | display-authors=3 | last4=Kübler | first4=Matthias | last5=Schwabe | first5=Jenny | last6=Gingrich | first6=Jeffrey C. | last7=Jauch | first7=Anna | last8=Cox | first8=Angela | last9=Nicklin | first9=Martin J.H. }}

{{cite journal | author=Kumar S |title=Identification and initial characterization of four novel members of the interleukin-1 family |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10308–14 |year= 2000 |pmid= 10744718 |doi=10.1074/jbc.275.14.10308 |name-list-format=vanc| author2=McDonnell PC | author3=Lehr R | display-authors=3 | last4=Tierney | first4=L | last5=Tzimas | first5=MN | last6=Griswold | first6=DE | last7=Capper | first7=EA | last8=Tal-Singer | first8=R | last9=Wells | first9=GI }}

{{cite journal | author=Busfield SJ |title=Identification and gene organization of three novel members of the IL-1 family on human chromosome 2 |journal=Genomics |volume=66 |issue= 2 |pages= 213–6 |year= 2000 |pmid= 10860666 |doi= 10.1006/geno.2000.6184 |name-list-format=vanc| author2=Comrack CA | author3=Yu G | display-authors=3 | last4=Chickering | first4=T.W. | last5=Smutko | first5=J.S. | last6=Zhou | first6=H. | last7=Leiby | first7=K.R. | last8=Holmgren | first8=L.M. | last9=Gearing | first9=D.P. }}

{{cite journal | author=Barton JL |title=A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities |journal=Eur. J. Immunol. |volume=30 |issue= 11 |pages= 3299–308 |year= 2001 |pmid= 11093146 |doi=10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S |name-list-format=vanc| author2=Herbst R | author3=Bosisio D | display-authors=3 | last4=Higgins | first4=Lee | last5=Nicklin | first5=Martin J. H. }}

{{cite journal | author=Pan G |title=IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp |journal=Cytokine |volume=13 |issue= 1 |pages= 1–7 |year= 2001 |pmid= 11145836 |doi= 10.1006/cyto.2000.0799 |name-list-format=vanc| author2=Risser P | author3=Mao W | display-authors=3 | last4=Baldwin | first4=DT | last5=Zhong | first5=AW | last6=Filvaroff | first6=E | last7=Yansura | first7=D | last8=Lewis | first8=L | last9=Eigenbrot | first9=C }}

{{cite journal | author=Lin H |title=Cloning and characterization of IL-1HY2, a novel interleukin-1 family member |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20597–602 |year= 2001 |pmid= 11278614 |doi= 10.1074/jbc.M010095200 |name-list-format=vanc| author2=Ho AS | author3=Haley-Vicente D | display-authors=3 | last4=Zhang | first4=J | last5=Bernal-Fussell | first5=J | last6=Pace | first6=AM | last7=Hansen | first7=D | last8=Schweighofer | first8=K | last9=Mize | first9=NK }}

{{cite journal | author=Debets R |title=Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2 |journal=J. Immunol. |volume=167 |issue= 3 |pages= 1440–6 |year= 2001 |pmid= 11466363 |doi= 10.4049/jimmunol.167.3.1440|name-list-format=vanc| author2=Timans JC | author3=Homey B | display-authors=3 | last4=Zurawski | first4=S | last5=Sana | first5=TR | last6=Lo | first6=S | last7=Wagner | first7=J | last8=Edwards | first8=G | last9=Clifford | first9=T }}

{{cite journal | author=Sims JE |title=A new nomenclature for IL-1-family genes |journal=Trends Immunol. |volume=22 |issue= 10 |pages= 536–7 |year= 2001 |pmid= 11574262 |doi=10.1016/S1471-4906(01)02040-3 |name-list-format=vanc| author2=Nicklin MJ | author3=Bazan JF | display-authors=3 | last4=Nicklin | first4=Martin J.H | last5=Barton | first5=Jenny L | last6=Bazan | first6=J.Fernando | last7=Kastelein | first7=Robert A | last8=Busfield | first8=Samantha J | last9=Ford | first9=John E }}

{{cite journal | author=Nicklin MJ |title=A sequence-based map of the nine genes of the human interleukin-1 cluster |journal=Genomics |volume=79 |issue= 5 |pages= 718–25 |year= 2002 |pmid= 11991722 |doi= 10.1006/geno.2002.6751 |name-list-format=vanc| author2=Barton JL | author3=Nguyen M | display-authors=3 | last4=Fitzgerald | first4=Michael G | last5=Duff | first5=Gordon W | last6=Kornman | first6=Ken }}

{{cite journal | author=Taylor SL |title=Genomic organization of the interleukin-1 locus |journal=Genomics |volume=79 |issue= 5 |pages= 726–33 |year= 2002 |pmid= 11991723 |doi= 10.1006/geno.2002.6752 |name-list-format=vanc| author2=Renshaw BR | author3=Garka KE | display-authors=3 | last4=Smith | first4=Dirk E | last5=Sims | first5=John E }}

{{cite journal | author=Kumar S |title=Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production |journal=Cytokine |volume=18 |issue= 2 |pages= 61–71 |year= 2003 |pmid= 12096920 |doi=10.1006/cyto.2002.0873 |name-list-format=vanc| author2=Hanning CR | author3=Brigham-Burke MR | display-authors=3 | last4=Rieman | first4=David J. | last5=Lehr | first5=Ruth | last6=Khandekar | first6=Sanjay | last7=Kirkpatrick | first7=Robert B. | last8=Scott | first8=Gilbert F. | last9=Lee | first9=John C. }}

{{cite journal | author=Bufler P |title=A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13723–8 |year= 2002 |pmid= 12381835 |doi= 10.1073/pnas.212519099 | pmc=129755 |name-list-format=vanc| author2=Azam T | author3=Gamboni-Robertson F | display-authors=3 | last4=Reznikov | first4=LL | last5=Kumar | first5=S | last6=Dinarello | first6=CA | last7=Kim | first7=SH }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | author=Grimsby S |title=Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity |journal=FEBS Lett. |volume=577 |issue= 1–2 |pages= 93–100 |year= 2005 |pmid= 15527767 |doi= 10.1016/j.febslet.2004.09.069 |name-list-format=vanc| author2=Jaensson H | author3=Dubrovska A | display-authors=3 | last4=Lomnytska | first4=Marta | last5=Hellman | first5=Ulf | last6=Souchelnytskyi | first6=Serhiy }}

{{cite journal | author=Hillier LW |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |name-list-format=vanc| author2=Graves TA | author3=Fulton RS | display-authors=3 | last4=Fulton | first4=Lucinda A. | last5=Pepin | first5=Kymberlie H. | last6=Minx | first6=Patrick | last7=Wagner-Mcpherson | first7=Caryn | last8=Layman | first8=Dan | last9=Wylie | first9=Kristine }}

See also

References

Further reading