| 释义 |
- Interactions
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene.[1]The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[1] InteractionsInterleukin-9 receptor has been shown to interact with YWHAZ.[2] See also- Cluster of differentiation
References1. ^1 {{cite web | title = Entrez Gene: IL9R interleukin 9 receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3581| accessdate = }}
2. ^{{cite journal |last=Sliva |first=D |authorlink= |author2=Gu M |author3=Zhu Y X |author4=Chen J |author5=Tsai S |author6=Du X |author7=Yang Y C |date=February 2000 |title=14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor |journal=Biochem. J. |volume=345 Pt 3 |issue= 3|pages=741–7 | issn = 0264-6021| pmid = 10642536 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1220812 | doi=10.1042/0264-6021:3450741}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Knoops L, Renauld JC |title=IL-9 and its receptor: from signal transduction to tumorigenesis |journal=Growth Factors |volume=22 |issue= 4 |pages= 207–15 |year= 2005 |pmid= 15621723 |doi= 10.1080/08977190410001720879 }}
- {{cite journal |vauthors=Renauld JC, Druez C, Kermouni A, etal |title=Expression cloning of the murine and human interleukin 9 receptor cDNAs |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5690–4 |year= 1992 |pmid= 1376929 |doi=10.1073/pnas.89.12.5690 | pmc=49358 |bibcode=1992PNAS...89.5690R }}
- {{cite journal |vauthors=Kimura Y, Takeshita T, Kondo M, etal |title=Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex |journal=Int. Immunol. |volume=7 |issue= 1 |pages= 115–20 |year= 1995 |pmid= 7718508 |doi=10.1093/intimm/7.1.115 }}
- {{cite journal |vauthors=Chang MS, Engel G, Benedict C, etal | title=Isolation and characterization of the human interleukin-9 receptor gene |journal=Blood |volume=83 |issue= 11 |pages= 3199–205 |year= 1994 |pmid= 8193355 |doi= }}
- {{cite journal |vauthors=Kermouni A, Van Roost E, Arden KC, etal |title=The IL-9 receptor gene (IL9R): genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter |journal=Genomics |volume=29 |issue= 2 |pages= 371–82 |year= 1996 |pmid= 8666384 |doi=10.1006/geno.1995.9992 }}
- {{cite journal |vauthors=Demoulin JB, Uyttenhove C, Van Roost E, etal |title=A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4710–6 |year= 1996 |pmid= 8756628 |doi= | pmc=231471}}
- {{cite journal |vauthors=Vermeesch JR, Petit P, Kermouni A, etal |title=The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin, escapes X inactivation and is expressed from the Y |journal=Hum. Mol. Genet. |volume=6 |issue= 1 |pages= 1–8 |year= 1997 |pmid= 9002663 |doi=10.1093/hmg/6.1.1 }}
- {{cite journal |vauthors=Bauer JH, Liu KD, You Y, etal |title=Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 9255–60 |year= 1998 |pmid= 9535918 |doi=10.1074/jbc.273.15.9255 }}
- {{cite journal |vauthors=Levitt RC, McLane MP, MacDonald D, etal |title=IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders |journal=J. Allergy Clin. Immunol. |volume=103 |issue= 5 Pt 2 |pages= S485–91 |year= 1999 |pmid= 10329852 |doi=10.1016/S0091-6749(99)70165-X }}
- {{cite journal |vauthors=Sliva D, Zhu YX, Tsai S, etal |title=Tip60 interacts with human interleukin-9 receptor alpha-chain |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 1 |pages= 149–55 |year= 1999 |pmid= 10486269 |doi= 10.1006/bbrc.1999.1083 }}
- {{cite journal |vauthors=Sliva D, Gu M, Zhu YX, etal |title=14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor |journal=Biochem. J. |volume=345 Pt 3 |issue= 3|pages= 741–7 |year= 2000 |pmid= 10642536 |doi=10.1042/0264-6021:3450741 | pmc=1220812 }}
- {{cite journal |vauthors=Ciccodicola A, D'Esposito M, Esposito T, etal |title=Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region |journal=Hum. Mol. Genet. |volume=9 |issue= 3 |pages= 395–401 |year= 2000 |pmid= 10655549 |doi=10.1093/hmg/9.3.395 }}
- {{cite journal |vauthors=De Smedt M, Verhasselt B, Kerre T, etal |title=Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development |journal=J. Immunol. |volume=164 |issue= 4 |pages= 1761–7 |year= 2000 |pmid= 10657622 |doi= 10.4049/jimmunol.164.4.1761}}
- {{cite journal |vauthors=Kauppi P, Laitinen T, Ollikainen V, etal |title=The IL9R region contribution in asthma is supported by genetic association in an isolated population |journal=Eur. J. Hum. Genet. |volume=8 |issue= 10 |pages= 788–92 |year= 2001 |pmid= 11039580 |doi= 10.1038/sj.ejhg.5200541 }}
- {{cite journal |vauthors=Abdelilah S, Latifa K, Esra N, etal |title=Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: role in IL-8 release |journal=J. Immunol. |volume=166 |issue= 4 |pages= 2768–74 |year= 2001 |pmid= 11160343 |doi= 10.4049/jimmunol.166.4.2768}}
- {{cite journal |vauthors=Asao H, Okuyama C, Kumaki S, etal |title=Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex |journal=J. Immunol. |volume=167 |issue= 1 |pages= 1–5 |year= 2001 |pmid= 11418623 |doi= 10.4049/jimmunol.167.1.1}}
- {{cite journal |vauthors=Little FF, Cruikshank WW, Center DM |title=Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells |journal=Am. J. Respir. Cell Mol. Biol. |volume=25 |issue= 3 |pages= 347–52 |year= 2001 |pmid= 11588013 |doi= 10.1165/ajrcmb.25.3.4349}}
- {{cite journal |vauthors=Tsukadaira A, Okubo Y, Koyama S, etal |title=Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor |journal=Exp. Lung Res. |volume=28 |issue= 2 |pages= 123–39 |year= 2002 |pmid= 11868823 |doi=10.1080/019021402753462040 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Melén E, Gullstén H, Zucchelli M, etal |title=Sex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation |journal=J. Med. Genet. |volume=41 |issue= 12 |pages= e123 |year= 2005 |pmid= 15591265 |doi= 10.1136/jmg.2004.023135 | pmc=1735647 }}
{{refend}}External links- {{MeshName|IL9R+protein,+human}}
{{NLM content}}{{Clusters of differentiation}}{{Cytokine receptors}}{{Interleukin receptor modulators}}{{membrane-protein-stub}} 2 : Type I cytokine receptors|Clusters of differentiation |