| 释义 |
- Function
- Histomorphology
- Pathology
- References
Intermediate trophoblast is a distinct subtype of trophoblastic tissue that arises from the cytotrophoblast.[1]It is sub-categorized by location:[1] - Villous intermediate trophoblast:
- at anchoring villi of trophoblastic column
- Implantation site intermediate trophoblast:
- at implantation site (or basal plate), differentiated from villous intermediate trophoblast
- Chorionic-type intermediate trophoblast
- at chorionic laeve of fetal membrane, differentiated from villous intermediate trophoblast
FunctionThe function of the implantation site intermediate trophoblast is to anchor the placenta to the maternal tissue. Histomorphology- Villous intermediate trophoblast[1]
- polyhedral and uniform nuclei
- prominent cell border; abundant eosinophilic to clear cytoplasm
- cohesive growth
- Implantation site intermediate trophoblast[1]
- pleomorphic irregular nuclei, large and hyperchromatic, may multinucleation
- abundant eosinophilic to amphophilic cytoplasm
- infiltrative growth (splitting muscle, replacing vascular wall ...etc)
- Chorionic-type intermediate trophoblast[1]
- round to polyhedral nuclei, may multinucleation
- abundant eosinophilic to clear cytoplasm
- cohesive growth
PathologyIntermediate trophoblasts are thought to be the cell of origin for:[2] - Exaggerated placental site (EPS): implantation site IT
- Placental site nodule (PSN): chorionic-type IT
- Placental site trophoblastic tumour (PSTT): implantation site IT
- Epithelioid trophoblastic tumour (ETT): chorionic-type IT
References1. ^1 2 3 4 {{cite journal |author=Shih IM, Kurman RJ |title=The pathology of intermediate trophoblastic tumors and tumor-like lesions |journal=Int. J. Gynecol. Pathol. |volume=20 |issue=1 |pages=31–47 |date=January 2001 |pmid=11192071 |doi= 10.1097/00004347-200101000-00004|url=}}
2. ^{{cite journal |author=Shih IM, Kurman RJ |title=The pathology of intermediate trophoblastic tumors and tumor-like lesions |journal=Int. J. Gynecol. Pathol. |volume=20 |issue=1 |pages=31–47 |date=January 2001 |pmid=11192071 |doi= 10.1097/00004347-200101000-00004|url=}}
{{Extraembryonic and fetal membranes}} 1 : Embryology |