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词条 Intrauterine device
释义

  1. Types

     Non-hormonal   Copper   Inert  Hormonal 

  2. Adverse effects

  3. Insertion and removal

  4. Mechanism

  5. History

     China 

  6. Cost

  7. References

{{Redirect|IUD|Intrauterine death|stillbirth}}{{Infobox birth control
| name = Intrauterine device
| image = IUD with scale.jpg
| image_size =
| caption = Copper IUD (Paragard T 380A)
| bc_type = Intrauterine
| synonym =
| tradename =
| date_first_use = 1800s[1]
| rate_type = Failure
| failure_measure = first year
| perfect_failure% = <1
| perfect_failure_ref = [1]
| typical_failure% = <1
| typical_failure_ref = [1]
| reversibility =
| user_reminders = None
| STD_protection_YesNo = No
| periods = Depends on the type
| weight_gain_loss = No effect
| benefits =
| risks =
| medical_notes =
}}

An intrauterine device (IUD), also known as intrauterine contraceptive device (IUCD or ICD) or coil,[2] is a small, often T-shaped birth control device that is inserted into a woman's uterus to prevent pregnancy. IUDs are one form of long-acting reversible birth control (LARC).[3] Among birth control methods, IUDs, along with contraceptive implants, result in the greatest satisfaction among users.[4] One study found that female family planning providers choose LARC methods more often (41.7%) than the general public (12.1%).[5]

IUDs are safe and effective in adolescents as well as those who have not previously had children.[4][6] Once an IUD is removed, even after long-term use, fertility returns to normal rapidly.[7] Copper devices have a failure rate of about 0.8% while hormonal (levonorgestrel) devices fail about 0.2% of the time within the first year of use.[8] In comparison, male sterilization and male condoms have a failure rate of about 0.15% and 15%, respectively.[9] Copper IUDs can also be used as emergency contraception within 5 days of unprotected sex.[10]

Although copper IUDs may increase menstrual bleeding and result in painful cramps,[11] hormonal IUDs may reduce menstrual bleeding or stop menstruation altogether.[15] However, women can have daily spotting for several months and it can take up to three months for there to be a 90% decrease in bleeding.[12] Cramping can be treated with NSAIDs.[17] More serious potential complications include expulsion (2–5%) and rarely perforation of the uterus (less than 0.7%).[15][13] IUDs do not affect breastfeeding and can be inserted immediately after delivery.[14] They may also be used immediately after an abortion.[15]

The use of IUDs has increased within the United States from 0.8% in 1995 to 5.6% from the period of 2006 to 2010.[16] The use of IUDs as a form of birth control dates from the 1800s.[17] A previous model known as the Dalkon shield was associated with an increased risk of pelvic inflammatory disease (PID). However, current models do not affect PID risk in women without sexually transmitted infections during the time of insertion.[18]

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Types

The types of intrauterine devices available, and the names they go by, differ by location. In the United States, there are two types available:[19]

  • Nonhormonal: Copper-containing IUD (ParaGard and others)
  • Hormonal: Progestogen-releasing IUD (Mirena and others)

The WHO ATC labels both copper and hormonal devices as IUDs. In the United Kingdom, there are more than 10 different types of copper IUDs available. In the United Kingdom, the term IUD refers only to these copper devices. Hormonal intrauterine contraception is considered to be a different type of birth control and is labeled with the term intrauterine system (IUS).[20][21]

Copper[22]Mirena[23]Skyla[24]Liletta[25]Kyleena[26]
Hormone (total in device)None52 mg

levonorgestrel

13.5 mg

levonorgestrel

52 mg

levonorgestrel

19.5 mg levonorgestrel
Initial amount releasedNone20 μg/day14 μg/day18.6 μg/day16 μg/day
Approved effectiveness10 years (12 years)5 years (7 years)3 years3 years (5 years)5 years
Mechanism of action Copper toxic to sperm-Levonorgestrel thickens cervical mucus to prevent sperm from reaching egg-Prevents ovulation at times
Advantages among IUDs -No hormones-Emergency contraception-Various hormone level options-Lighter periods after 3 months
Disadvantages among IUDsHeavier menstrual flow and crampsOvarian cysts (although they can be asymptomatic)

Non-hormonal

Copper

{{Main|Copper IUDs}}

Most copper IUDs have a plastic T-shaped frame that is wound around with pure electrolytic copper wire and/or has copper collars (sleeves). The arms of the frame hold the IUD in place near the top of the uterus. The Paragard TCu 380a measures 32 mm (1.26") horizontally (top of the T), and 36 mm (1.42") vertically (leg of the T). Copper IUDs have a first year failure rate ranging from 0.1 to 2.2%.[27] They work by damaging sperm and disrupting their motility so that they are not able to join an egg. Specifically, copper acts as a spermicide within the uterus by increasing levels of copper ions, prostaglandins, and white blood cells within the uterine and tubal fluids.[11][28] The increased copper ions in the cervical mucus inhibit the sperm's motility and viability, preventing sperm from traveling through the cervical mucus, or destroying it as it passes through.[29] Copper can also alter the endometrial lining, but studies show that while this alteration can prevent implantation of a fertilized egg ("blastocyst"), it cannot disrupt one that has already been implanted.[30]

Advantages of the copper IUD include its ability to provide emergency contraception up to five days after unprotected sex. It is the most effective form of emergency contraception available.[31] It works by preventing fertilization or implantation but does not affect already implanted embryos.[30] It contains no hormones, so it can be used while breastfeeding, and fertility returns quickly after removal.[32]

Copper IUDs also last longer and are available in a wider range of sizes and shapes compared to hormonal IUDs.[12] Disadvantages include the possibility of heavier menstrual periods and more painful cramps.[11]

IUDs that contain gold or silver also exist.[20][33] Other shapes of IUD include the so-called U-shaped IUDs, such as the Load and Multiload, and the frameless IUD that holds several hollow cylindrical minuscule copper beads. It is held in place by a suture (knot) to the fundus of the uterus. It is mainly available in China and Europe. A framed copper IUD called the IUB SCu300 coils when deployed and forms a three-dimensional spherical shape. It is based on a nickel titanium shape memory alloy core.[34] In addition to copper, noble metal and progestogen IUDs; people in China can get copper IUDs with indomethacin. This non-hormonal compound reduces the severity of menstrual bleeding, and these coils are popular.[35]

Inert

Inert IUDs do not have a bioactive component. They are made of inert materials like stainless steel (such as the stainless steel ring (SSR), a flexible ring of steel coils that can deform to be inserted through the cervix) or plastic (such as the Lippes Loop, which can be inserted through the cervix in a cannula and takes a trapezoidal shape within the uterus). They are less effective than copper or hormonal IUDs, with a side effect profile similar to copper IUDs. Their primary mechanism of action is inducing a local foreign body reaction, which makes the uterine environment hostile both to sperm and to implantation of an embryo.[36] They may have higher rates of preventing pregnancy after fertilization, instead of before fertilization, compared to copper or hormonal IUDs.[37]

Inert IUDs are not yet approved for use in the United States, UK, or Canada. In China, where IUDs are the most common form of contraception, copper IUD production replaced inert IUD production in 1993.[38] However, as of 2008, the most common IUD used by immigrants presenting to Canadian clinics for removal of IUDs placed in China was still the SSR. Because the SSR has no string for removal, it can present a challenge to healthcare providers unfamiliar with IUD types not available in their region.[39]

Hormonal

{{Main|Hormonal IUDs}}

Hormonal IUDs (brand names Mirena, Skyla, Kyleena, and Liletta; referred to as intrauterine systems in the UK) work by releasing a small amount of levonorgestrel, a progestin. Each type varies in size, amount of levonorgestrel released, and duration. For example, Mirena and Liletta measure 32x32mm while Skyla and Kyleena measure 28x30mm. The primary mechanism of action is making the inside of the uterus uninhabitable for sperm.[40] They can also thin the endometrial lining and potentially impair implantation but this is not their usual function.[41][42] Because they thin the endometrial lining, they can also reduce or even prevent menstrual bleeding. As a result, they are used to treat menorrhagia (heavy menses), once pathologic causes of menorrhagia (such as uterine polyps) have been ruled out.[43]

The progestin released by hormonal IUDs primarily acts locally; use of Mirena results in much lower systemic progestin levels than other very-low-dose progestogen only contraceptives.[44]

Mirena is approved for use up to five years in the US, though studies support its efficacy for up to seven years.[45] Like Mirena, Kyleena is also approved for up to 5 years but is smaller and releases slightly less levonorgestrel. Skyla is even smaller and releases an even lower dose of levonorgestrel than Kyleena, but is only approved for up to three years. Liletta is more similar to Mirena in both shape and dose of levonorgestrel released; it has currently been approved for usage up to three years.[46]

Adverse effects

{{Further|IUD with progestogen|IUD with copper}}

Regardless of IUD type, there are some potential side effects that are similar for all IUDs. Some of these side effects include bleeding pattern changes, expulsion, pelvic inflammatory disease (especially in the first 21 days after insertion), and rarely uterine perforation. A small probability of pregnancy remains after IUD insertion, and when it occurs there's a greater risk of ectopic pregnancy.[47]

IUDs with progestogen confer an increased risk of ovarian cysts,[48] and IUDs with copper confer an increased risk of heavier periods.

Menstrual cup companies recommend that women with IUDs who are considering using menstrual cups should consult with their gynecologists before use. There have been rare cases in which women using IUDs dislodged them when removing their menstrual cups, however, this can also happen with tampon use.[49]

Unlike condoms, the IUD does not protect against sexually transmitted infections.[50]

MythFact
IUDs can cause infertilityIUDs do not lead to infertility or make it harder for a woman to become pregnant. Some of the prior studies that found an association between IUDs and infertility were investigating the Dalkon Shield which is no longer used.[51]
IUDs cause infectionsIUDs do not cause increased infection. Once again, this is likely referring to the Dalkon Shield which is no longer used. The IUD contained multifilament strings which provided bacteria a space to grow and move up the string. Today’s IUDs use monofilament strings in order to prevent this from happening. [52] However, as with any medical intervention, IUDs can lead to increased risk of infection immediately after the insertion.
IUDs should only be used by older and/or monogamous womenIUDs are not solely for older and/or monogamous women. According to the U.S. Medical Eligibility Criteria for Contraceptive Use, women who have not had children and adolescents are classified as a category 2 for IUD use.[53] This means that the benefits generally outweigh the risks although more careful attention may be required.[54]
A woman is supposed to have her period regularly to be healthy.Women do not need to have periods regularly. A period signifies the end of a woman’s body preparing for pregnancy. If a woman does not desire pregnancy, then she does not need a period. There is a condition known as polycystic ovarian syndrome (PCOS) which causes women to miss their periods and can lead to an increased risk of endometrial cancer.[55] However, an IUD causes the endometrial lining of a uterus to thin which is the opposite of what is occurring with PCOS.  

Insertion and removal

It is difficult to predict what a woman will experience during IUD insertion or removal. Some women describe the insertion as cramps, some as a pinch, and others do not feel anything. Substantial pain with insertion that needs active management occurs in approximately 17% of nulliparous women and approximately 11% of parous women.[56] In such cases, NSAIDs are effective.[56] However, no prophylactic analgesic drug have been found to be effective for routine use for women undergoing IUD insertion.[56]

During the insertion procedure, health care providers use a speculum to find the cervix (the opening to the uterus) and then use an insertion device to place the IUD in the uterus. The insertion device goes through the cervix which is what causes the pain felt during the insertion. The procedure itself, if uncomplicated, should take no more than five to ten minutes.[57] Generally, the removal is not nearly as painful as the insertion because there is no instrument that needs to go through the cervix.[58] This process requires that the health care provider to find the cervix with a speculum and then use ring forceps, which only go into the vagina, in order to grasp the IUD strings and then pull the IUD out.

Mechanism

IUDs primarily work by preventing fertilization.[59] The progestogen released from hormonal IUDs mainly works by thickening the cervical mucus, preventing sperm from reaching the fallopian tubes. IUDs may also function by preventing ovulation from occurring but this only occurs partially.[60][61]

Copper IUDs do not contain any hormones, but release copper ions, which are toxic to sperm. They also cause the uterus and fallopian tubes to produce a fluid that contains white blood cells, copper ions, enzymes, and prostaglandins, which is also toxic to sperm.[60] The very high effectiveness of copper-containing IUDs as emergency contraceptives implies they may also act by preventing implantation of the blastocyst.[62][63]

History

The history of intrauterine devices dates back to the early 1900s. Unlike IUDs, early interuterine devices crossed both the vagina and the uterus, causing a high rate of pelvic inflammatory disease in a time period when gonorrhea was more common. The first IUD was developed in 1909 by the German physician Richard Richter, of Waldenburg. His device was made of silkworm gut and was not widely used.[64]

Ernst Gräfenberg, another German physician (after whom the G-spot is named), created the first Ring IUD, Gräfenberg's ring, made of silver filaments. His work was suppressed during the Nazi regime, when contraception was considered a threat to Aryan women.[64] He moved to the United States, where his colleagues H. Hall and M. Stone took up his work after his death and created the stainless steel Hall-Stone Ring. A Japanese doctor named Tenrei Ota also developed a silver or gold IUD called the Precea or Pressure Ring.[64]

Jack Lippes helped begin the increase of IUD use in the United States in the late 1950s. In this time, thermoplastics, which can bend for insertion and retain their original shape, became the material used for first-generation IUDs. Lippes also devised the addition of the monofilament nylon string, which facilitates IUD removal. His trapezoid shape Lippes Loop IUD became one of the most popular first-generation IUDs. In the following years, many different shaped plastic IUDs were invented and marketed.[64] These included the infamous Dalkon Shield, whose poor design caused bacterial infection and led to thousands of lawsuits. Although the Dalkon shield was removed from the market, it had a lasting, negative impact on IUD use and reputation in the United States.[65] Lazar C. Margulies developed the first plastic IUD using thermoplastics in the 1960s.[66] His innovation allowed insertion of the IUD into the uterus without the need to dilate the cervix.[67]

The invention of the copper IUD in the 1960s brought with it the capital 'T' shaped design used by most modern IUDs. U.S. physician Howard Tatum determined that the 'T' shape would work better with the shape of the uterus, which forms a 'T' when contracted. He predicted this would reduce rates of IUD expulsion.[64] Together, Tatum and Chilean physician Jaime Zipper discovered that copper could be an effective spermicide and developed the first copper IUD, TCu200. Improvements by Tatum led to the creation of the TCu380A (ParaGard), which is currently the preferred copper IUD.[64]

The hormonal IUD was also invented in the 1960s and 1970s; initially the goal was to mitigate the increased menstrual bleeding associated with copper and inert IUDs. The first model, Progestasert, was conceived of by Antonio Scommegna and created by Tapani J. V. Luukkainen, but the device only lasted for one year of use.[65] Progestasert was manufactured until 2001.[68] One commercial hormonal IUD which is currently available, Mirena, was also developed by Luukkainen and released in 1976.[64] The manufacturer of the Mirena, Bayer AG, became the target of multiple lawsuits over allegations that Bayer failed to adequately warn users that the IUD could pierce the uterus and migrate to other parts of the body.[69]

China

In China, the use of IUDs by state health services was part of the government's efforts to limit birth rates. From 1980 to 2014, 324 million women were inserted with IUDs, in addition to the 107 million who had tubal ligation. Women who refused could lose their government employment and their children could lose access to public schools. The IUDs inserted in this way were modified such that they could not be removed in a doctor's office (meant to be left indefinitely), and surgical removal is usually needed.[70] Until the mid-1990s, the state-preferred IUD was a stainless steel ring,[71][72] which had a higher rate of complications compared to other types of IUD. It gave rise to the idiom {{Ruby-zh-p|上环|Shànghuán}} meaning "insert a loop". Nowadays, the IUDs include T and V shapes, the former being the most common and easiest to remove.

To implement the two-child policy, the government announced IUD-removals be paid for by the government.[70] Women "who are allowed to have another child" (see one-child policy) or "who cannot continue to have the IUD for health reasons" get free removals, everyone else do not.[73]

Cost

The price of an IUD may range from $0 to $1300.00.[74] {{clarify|date=December 2018}} The price includes medical exams, insertion, and follow-up visits. Under the Affordable Care Act, most insurance plans are required to cover all forms of birth control, including IUDs, though they may not cover all IUD brands.[75]

References

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30. ^1 {{cite web | title = Facts are Important: Emergency Contraception (EC) and Intrauterine Devices (IUDs) are Not Abortifacients | publisher = American Congress of Obstetricians and Gynecologists | date = June 12, 2014 | url = http://www.acog.org/-/media/Departments/Government-Relations-and-Outreach/FactsAreImportantEC.pdf?dmc=1&ts=20150127T1149330103 | format = PDF | accessdate = July 14, 2015 |quote=Copper ions released from the IUD create an environment that is toxic to sperm, preventing fertilization.14 Copper can also alter the endometrial lining, but studies show that this alteration can prevent implantation, but not disrupt implantation}}
31. ^{{citation|title=The efficacy of intrauterine devices for emergency contraception: a systematic review of 35 years of experience|date=July 2012|url=http://humrep.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=22570193|journal=Hum. Reprod.|volume=27|issue=7|pages=1994–2000|doi=10.1093/humrep/des140|pmid=22570193|vauthors=Cleland K, Zhu H, Goldstuck N, Cheng L, Trussell J|pmc=3619968}}
32. ^{{citation|title=Recovery of fertility after use of the levonorgestrel 20 mcg/d or Copper T 380 Ag intrauterine device|date=September 1986|journal=Contraception|volume=34|issue=3|pages=261–7|doi=10.1016/0010-7824(86)90007-7|pmid=3098498|display-authors=etal|vauthors=Belhadj H, Sivin I, Diaz S}}
33. ^{{cite web |author=Schering |date=May 13, 2003 |title=Nova T380 Patient information leaflet (PIL) |url=http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=3641 |accessdate=2007-04-27 |archive-url=https://web.archive.org/web/20070928060627/http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=3641 |archive-date=September 28, 2007 |dead-url=yes |df=mdy-all }}
34. ^{{citation |vauthors=Baram I, Weinstein A, Trussell J |title=The IUB, a newly invented IUD: a brief report |journal=Contraception |volume=89 |issue=2 |pages=139–141 |date=February 2014 |doi=10.1016/j.contraception.2013.10.017 |pmid=24309220 |pmc=3947156}}
35. ^{{cite journal|date=December 2011|title=[A multi-center randomized controlled trial of intrauterine device use in Chinese women]|journal=Zhonghua Yi Xue Za Zhi|language=Chinese|volume=91|issue=45|pages=3172–5|pmid=22333096|vauthors=Li Y, Zhang SM, Chen F, etal}}
36. ^{{cite journal | last=Ortiz | first=ME |author2=Croxatto HB | title=Copper-T intrauterine device and levonorgestrel intrauterine system: biological bases of their mechanism of action. | journal=Contraception | volume=75 | issue=6 | pages=S16–30 | date=June 2007 | pmid=17531610 | doi=10.1016/j.contraception.2007.01.020}}
37. ^{{cite journal | last=ESHRE Capri Workshop Group | title=Intrauterine devices and intrauterine systems | journal=Human Reproduction Update | volume=14 | issue=3 | pages=197–208 | date=April 2008 | pmid=18400840 | doi=10.1093/humupd/dmn003}}
38. ^{{cite journal |author=Bilian X |title=Chinese experience with intrauterine devices |journal=Contraception |volume=75 |issue=6 Suppl |pages=S31–4 |date=June 2007 |pmid=17531613 |doi=10.1016/j.contraception.2006.12.007 |url=}}
39. ^{{cite journal |author=Cheung VY |title=A 10-year experience in removing Chinese intrauterine devices |journal=Int J Gynaecol Obstet |volume=109 |issue=3 |pages=219–22 |date=June 2010 |pmid=20219193 |doi=10.1016/j.ijgo.2009.12.018 |url=}}
40. ^{{cite book|last1=Speroff|first1=Leon|last2=Darney|first2=Philip D.|year=2011|chapter=Intrauterine contraception|title=A clinical guide for contraception|edition=5th|location=Philadelphia|publisher=Lippincott Williams & Wilkins|pages=239–280|isbn=978-1-60831-610-6}} pp. 246–247:
Mechanism of action
The contraceptive action of all IUDs is mainly in the intrauterine cavity. Ovulation is not affected, and the IUD is not an abortifacient.58–60 It is currently believed that the mechanism of action for IUDs is the production of an intrauterine environment that is spermicidal.
Nonmedicated IUDs depend for contraception on the general reaction of the uterus to a foreign body. It is believed that this reaction, a sterile inflammatory response, produces tissue injury of a minor degree but sufficient to be spermicidal. Very few, if any, sperm reach the ovum in the fallopian tube.
The progestin-releasing IUD adds the endometrial action of the progestin to the foreign body reaction. The endometrium becomes decidualized with atrophy of the glands.65 The progestin IUD probably has two mechanisms of action: inhibition of implantation and inhibition of sperm capacitation, penetration, and survival.

41. ^{{cite journal|last1=ESHRE Capri Workshop|first1=Group|title=Intrauterine devices and intrauterine systems.|journal=Human Reproduction Update|date=2008|volume=14|issue=3|pages=197–208|pmid=18400840|quote=Both copper IUDs and levonorgestrel releasing IUSs may interfere with implantation|doi=10.1093/humupd/dmn003}}
42. ^{{cite book|last1=Hatcher|first1=Robert A.|title=Contraceptive technology|date=2011|publisher=Ardent Media|location=[New York, N.Y.]|isbn=978-1-59708-004-0|page=162|edition=20th rev.|quote=Although the precise mechanism of action is not known, currently available IUCs work primarily by preventing sperm from fertilizing ova.26 IUCs are not abortifacients: they do not interrupt an implanted pregnancy.27 Pregnancy is prevented by a combination of the "foreign body effect" of the plastic or metal frame and the specific action of the medication (copper or levonorgestrel) that is released. Exposure to a foreign body causes a sterile inflammatory reaction in the intrauterine environment that is toxic to sperm and ova and impairs implantation.28,29 The production of cytotoxic peptides and activation of enzymes lead to inhibition of sperm motility, reduced sperm capacitation and survival, and increased phagocytosis of sperm.30,31… The progestin in the LNg IUC enhances the contraceptive action of the device by thickening cervical mucus, suppressing the endometrium, and impairing sperm function. In addition, ovulation is often impaired as a result of systemic absorption of levonorgestrel}}
43. ^{{citation |author1=Luis Bahamondes |author2=M Valeria Bahamondes |author3=Ilza Monteiro. | year = 2008 | title = Levonorgestrel-releasing intrauterine system: uses and controversies. | journal = Expert Review of Medical Devices | volume = 5|issue=4 | pages = 437–45 | doi=10.1586/17434440.5.4.437 | pmid=18573044}}
44. ^{{cite journal |author=Malik S |title=Levonorgestrel-IUS system and endometrial manipulation |journal=Journal of Mid-life Health |volume=4 |issue=1 |pages=6–7 |date=January 2013 |pmid=23833526 |pmc=3702070 |doi=10.4103/0976-7800.109625 |url=}}
45. ^{{cite journal |vauthors=Sivin I, Stern J, Coutinho E, etal |title=Prolonged intrauterine contraception: a seven-year randomized study of the levonorgestrel 20 mcg/day (LNg 20) and the Copper T380 Ag IUDS |journal=Contraception |volume=44 |issue=5 |pages=473–80 |date=November 1991 |pmid=1797462 |doi= 10.1016/0010-7824(91)90149-a|url=}}
46. ^{{Cite journal|url = http://secure.medicalletter.org/TML-article-1472b|title = Liletta - A Third Levonorgestrel-Releasing IUD|date = July 6, 2015|journal = The Medical Letter on Drugs and Therapies|doi = |pmid = 26147893|access-date = Oct 6, 2015 |volume=57 |issue = 1472|pages=99–100}}
47. ^{{cite web |title=ParaGard (copper IUD) |url=https://www.mayoclinic.org/tests-procedures/paragard/about/pac-20391270 |website=Mayo Clinic |accessdate=30 November 2018}}
48. ^{{citation |author1=Bahamondes L |author2=Hidalgo M |author3=Petta CA |author4=Diaz J |author5=Espejo-Arce X |author6=Monteiro-Dantas C. | year = 2003 | title = Enlarged ovarian follicles in users of a levonorgestrel-releasing intrauterine system and contraceptive implant | journal = J. Reproduc. Med. | volume = 48 | issue = 8 | pages = 637–640 | pmid = 12971147}}
49. ^{{cite web |url=http://www.femininewear.co.uk/cup-use-and-iuds-24-w.asp |title=Menstrual Cup use and IUDs |publisher=Feminine Wear |accessdate=22 December 2013}}
50. ^{{cite web|title=What Are the Side Effects & Complications of the IUD?|url=https://www.plannedparenthood.org/learn/birth-control/iud/what-are-the-disadvantages-of-iuds|website=www.plannedparenthood.org|accessdate=21 November 2017|language=en}}
51. ^{{Cite book|url=https://books.google.com/?id=ZQehCgAAQBAJ&pg=PA273&dq=infertility+and+iud#v=onepage&q=infertility%20and%20iud&f=false|title=The Handbook of Contraception: A Guide for Practical Management|last=Shoupe|first=Donna|last2=Jr|first2=Daniel R. Mishell|date=2015-09-28|publisher=Humana Press|isbn=9783319201856|language=en}}
52. ^{{Cite book|url=https://books.google.com/?id=v4krPhqFG8sC&pg=PA529&lpg=PA529&dq=COPPER+AND+MIRENA+MONOFILAMENT#v=onepage&q=COPPER%20AND%20MIRENA%20MONOFILAMENT&f=false|title=Danforth's Obstetrics and Gynecology|last=Gibbs|first=Ronald S.|date=2008|publisher=Lippincott Williams & Wilkins|isbn=9780781769372|language=en}}
53. ^{{Cite web|url=https://www.cdc.gov/reproductivehealth/contraception/pdf/summary-chart-us-medical-eligibility-criteria_508tagged.pdf|title=Summary Chart of U.S. Medical Eligibility Criteria for Contraceptive Use|date=|website=www.cdc.gov|access-date=25 March 2018}}
54. ^{{Cite journal|last=Curtis|first=Kathryn M.|last2=Tepper|first2=Naomi K.|last3=Jatlaoui|first3=Tara C.|last4=Berry-Bibee|first4=Erin|last5=Horton|first5=Leah G.|last6=Zapata|first6=Lauren B.|last7=Simmons|first7=Katharine B.|last8=Pagano|first8=H. Pamela|last9=Jamieson|first9=Denise J.|date=2016|title=U.S. Medical Eligibility Criteria for Contraceptive Use, 2016|url=https://www.cdc.gov/mmwr/volumes/65/rr/rr6503a1.htm|journal=MMWR. Recommendations and Reports|language=en-us|volume=65|issue=3|pages=1–103|doi=10.15585/mmwr.rr6503a1|pmid=27467196|issn=1057-5987}}
55. ^{{Cite journal|last=Dumesic|first=Daniel A.|last2=Lobo|first2=Rogerio A.|date=August 2013|title=Cancer risk and PCOS|journal=Steroids|volume=78|issue=8|pages=782–785|doi=10.1016/j.steroids.2013.04.004|issn=1878-5867|pmid=23624028}}
56. ^1 2 {{Cite journal|last1=Gemzell-Danielsson|first1=K.|last2=Mansour|first2=D.|last3=Fiala|first3=C.|last4=Kaunitz|first4=A. M.|last5=Bahamondes|first5=L.|year=2013|title=Management of pain associated with the insertion of intrauterine contraceptives|journal=Human Reproduction Update|volume=19|issue=4|pages=419–427|doi=10.1093/humupd/dmt022|pmc=3682672|pmid=23670222}}
57. ^{{Cite web|url=https://www.plannedparenthood.org/learn/birth-control/iud/whats-an-iud-insertion-like|title=What's an IUD insertion like?|website=www.plannedparenthood.org|language=en|access-date=2018-03-29}}
58. ^{{Cite news|url=https://www.self.com/story/iud-removal-facts|title=This Is What to Expect After Getting Your IUD Removed|last=Barnes|first=Zahra|work=SELF|access-date=2018-03-30|language=en}}
59. ^{{cite book|url=https://books.google.com/books?id=-3ufSTqeb6cC&pg=PA528|title=Obstetrics : normal and problem pregnancies|date=2012-01-01|publisher=Elsevier/Saunders|isbn=9781437719352|editor=Steven G. Gabbe|edition=6th|location=Philadelphia|pages=528|display-editors=etal}}
60. ^1 {{Cite web|url=http://center4research.org/medical-care-for-adults/birth-control/understanding-the-iud/|title=Archived copy|archive-url=https://archive.is/20130808133036/http://center4research.org/medical-care-for-adults/birth-control/understanding-the-iud/|archive-date=2013-08-08|dead-url=yes|access-date=2013-08-08|df=}}
61. ^{{Cite web|url=http://www.mayoclinic.org/tests-procedures/mirena/basics/definition/prc-20012867|title=Mirena (DIU hormonal) - Mayo Clinic}}
62. ^{{cite book|title=Contraceptive technology|last1=Trussell|first1=James|last2=Schwarz|first2=Eleanor Bimla|publisher=Ardent Media|year=2011|isbn=978-1-59708-004-0|editor1-last=Hatcher|editor1-first=Robert A.|edition=20th revised|location=New York|pages=113–145|chapter=Emergency contraception|issn=0091-9721|oclc=781956734|editor2-last=Trussell|editor2-first=James|editor3-last=Nelson|editor3-first=Anita L.|editor4-last=Cates|editor4-first=Willard Jr.|editor5-last=Kowal|editor5-first=Deborah|editor6-last=Policar|editor6-first=Michael S.}} p. 121:
Mechanism of action
Copper-releasing IUCs
When used as a regular or emergency method of contraception, copper-releasing IUCs act primarily to prevent fertilization. Emergency insertion of a copper IUC is significantly more effective than the use of ECPs, reducing the risk of pregnancy following unprotected intercourse by more than 99%.2,3 This very high level of effectiveness implies that emergency insertion of a copper IUC must prevent some pregnancies after fertilization.
Emergency contraceptive pills
To make an informed choice, women must know that ECPs—like the birth control pill, patch, ring, shot, and implant,76and even like breastfeeding77—prevent pregnancy primarily by delaying or inhibiting ovulation and inhibiting fertilization, but may at times inhibit implantation of a fertilized egg in the endometrium. However, women should also be informed that the best available evidence indicates that ECPs prevent pregnancy by mechanisms that do not involve interference with post-fertilization events.
ECPs do not cause abortion78 or harm an established pregnancy. Pregnancy begins with implantation according to medical authorities such as the US FDA, the National Institutes of Health79 and the American College of Obstetricians and Gynecologists (ACOG).80
Ulipristal acetate (UPA). One study has demonstrated that UP can delay ovulation.81... Another study found that UPA altered the endometrium, but whether this change would inhibit implantation is unknown.82
p. 122:
Progestin-only emergency contraceptive pills. Early treatment with ECPs containing only the progestin levonorgestrel has been show to impair the ovulatory process and luteal function.83–87
p. 123:
Combined emergency contraceptive pills. Several clinical studies have shown that combined ECPs containing ethinyl estradiol and levonorgestrel can inhibit or delay ovulation.107–110

63. ^{{cite book|url=http://www.fsrh.org/pdfs/CEUguidanceEmergencyContraception11.pdf|title=Clinical guidance: emergency contraception|author1=RCOG Faculty of Sexual|author2=Reproductive Healthcare|author3=Clinical Effectiveness Unit|date=January 2012|publisher=Royal College of Obstetricians and Gynaecologists|location=London|issn=1755-103X|accessdate=2012-04-30}}p.3:
How does EC work?
In 2002, a judicial review ruled that pregnancy begins at implantation, not fertilisation.8 The possible mechanisms of action should be explained to the patient as some methods may not be acceptable, depending on individual beliefs about the onset of pregnancy and abortion.
Copper-bearing intrauterine device (Cu-IUD). Copper is toxic to the ovum and sperm and thus the copper-bearing intrauterine device (Cu-IUD) is effective immediately after insertion and works primarily by inhibiting fertilisation.9–11 A systematic review on mechanisms of action of IUDs showed that both pre- and postfertilisation effects contribute to efficacy.11If fertilisation has already occurred, it is accepted that there is an anti-implantation effect,12,13
Levonorgestrel (LNG). The precise mode of action of levonorgestrel (LNG) is incompletely understood but it is thought to work primarily by inhibition of ovulation.16,17
Ulipristal acetate (UPA). UPA’s primary mechanism of action is thought to be inhibition or delay of ovulation.2

64. ^1 2 3 4 5 6 {{cite journal |last=Thiery |first=Michel |title=Pioneers of the intrauterine device |journal=European Journal of Contraception and Reproductive Health Care |volume=2 |issue=1 |pages=15–23 |date=March 1997 |pmid=9678105 |doi=10.1080/13625189709049930 |url=http://www.contrel.be/Articles%20and%20videos/Pioneers%20of%20the%20intrauterine%20device.pdf |archivedate=August 20, 2006 |archiveurl=https://web.archive.org/web/20060820044102/http://www.contrel.be/Articles%20and%20videos/Pioneers%20of%20the%20intrauterine%20device.pdf}}
65. ^1 {{citation |author=Thiery M |title=Intrauterine contraception: from silver ring to intrauterine contraceptive implant |journal=Eur. J. Obstet. Gynecol. Reprod. Biol. |volume=90 |issue=2 |pages=145–52 |date=June 2000 |pmid=10825633 |url=http://linkinghub.elsevier.com/retrieve/pii/S0301211500002621 |doi=10.1016/s0301-2115(00)00262-1}}
66. ^{{Cite journal|last=Thiery|first=M.|date=March 1997|title=Pioneers of the Intrauterine Device|url=http://www.contrel.be/Articles%20and%20videos/Pioneers%20of%20the%20intrauterine%20device.pdf|journal=The European Journal of Contraception and Reproductive Health Care|volume=2|issue=1|doi=|pmid=|archive-url=https://web.archive.org/web/20060820044102/http://www.contrel.be/Articles%20and%20videos/Pioneers%20of%20the%20intrauterine%20device.pdf|archive-date=20 August 2006|access-date=24 March 2016}}
67. ^{{Cite book|url=https://books.google.com/books?id=aNn_AwAAQBAJ&lpg=PA306&dq=%22Lazar%20C.%20Margulies%22&pg=PA306#v=onepage&q=%22Lazar%20C.%20Margulies%22&f=false|title=The Birth Control Movement and American Society: From Private Vice to Public Virtue|last=Reed|first=James|publisher=Princeton University Press|year=1984|isbn=9781400856596|location=|pages=306}}
68. ^{{cite web |last=Smith (pseudonym) |first=Sydney |title=Contraceptive Concerns |work=medpundit: Commentary on medical news by a practicing physician. |date= March 8, 2003 |url=http://www.medpundit.blogspot.com/2003_03_02_medpundit_archive.html |accessdate=2006-07-16 }}
69. ^{{Cite web | url=http://newsandinsight.thomsonreuters.com/Legal/News/2013/05_-_May/Judge_calls_for_female_lawyers_on_plaintiffs__committee_in_Mirena_MDL/ | title=Legal Current Events | Westlaw Practitioner Insights}}
70. ^1 {{cite news|last1=Wee|first1=Sui-lee|title=After One-Child Policy, Outrage at China’s Offer to Remove IUDs|url=https://www.nytimes.com/2017/01/07/world/asia/after-one-child-policy-outrage-at-chinas-offer-to-remove-iuds.html|accessdate=8 January 2017|work=The New York Times|date=7 January 2017}}
71. ^{{cite web|url=http://www.obgyn.net/obgyn-ultrasound/chinese-ring|title=Chinese ring|website=www.obgyn.net|date=July 14, 2011}}
72. ^{{cite web|url=https://www.fhi360.org/sites/default/files/webpages/Modules/IUD/s1pg6.htm|title=Intrauterine Devices (IUDs)|website=www.fhi360.org}}
73. ^{{cite web|title=One Child Policy Leaves Millions of Chinese Women With Unwanted IUDs|url=http://www.rfa.org/english/women/onechild-iud-01132017173100.html|website=Radio Free Asia|language=en|date=January 13, 2017}}
74. ^{{Cite web|url=https://www.plannedparenthood.org/learn/birth-control/iud|title=IUD Birth Control {{!}} Info About Mirena & ParaGard IUDs|website=www.plannedparenthood.org|language=en|access-date=2018-12-02}}
75. ^{{Cite web|url=https://www.plannedparenthood.org/learn/birth-control/iud/how-can-i-get-an-iud|title=Where Can I Buy the IUD & How Much Will It Cost?|website=www.plannedparenthood.org|language=en|access-date=2019-03-27}}
{{Birth control methods|state=show}}{{Hormonal contraceptives}}{{Dosage forms}}

3 : Intrauterine contraception|Dosage forms|Drug delivery devices
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