| 释义 |
- References
- Further reading
{{Infobox_gene}}Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.[3]
}}References1. ^{{cite journal |vauthors=Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH | title = Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas | journal = Oncogene | volume = 18 | issue = 32 | pages = 4530–7 |date=Oct 1999 | pmid = 10467397 | pmc = | doi = 10.1038/sj.onc.1202806 }}
2. ^{{cite journal |vauthors=Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R | title = Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II | journal = Cell | volume = 123 | issue = 2 | pages = 265–76 |date=Oct 2005 | pmid = 16239144 | pmc = | doi = 10.1016/j.cell.2005.08.019 }}
3. ^1 {{cite web | title = Entrez Gene: INTS6 integrator complex subunit 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26512| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Buchsbaum S, Morris C, Bochard V, Jalinot P |title=Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle. |journal=Oncogene |volume=26 |issue= 35 |pages= 5132–44 |year= 2007 |pmid= 17310990 |doi= 10.1038/sj.onc.1210314 }}
- {{cite journal |vauthors=Hernández M, Papadopoulos N, Almeida TA |title=Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions. |journal=Cancer Genet. Cytogenet. |volume=163 |issue= 1 |pages= 91–2 |year= 2006 |pmid= 16271964 |doi= 10.1016/j.cancergencyto.2005.04.014 }}
- {{cite journal |vauthors=Röpke A, Buhtz P, Böhm M, etal |title=Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer. |journal=Oncogene |volume=24 |issue= 44 |pages= 6667–75 |year= 2005 |pmid= 16007164 |doi= 10.1038/sj.onc.1208824 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Wieland I, Sell C, Weidle UH, Wieacker P |title=Ectopic expression of DICE1 suppresses tumor cell growth. |journal=Oncol. Rep. |volume=12 |issue= 2 |pages= 207–11 |year= 2005 |pmid= 15254679 |doi= 10.3892/or.12.2.207}}
- {{cite journal |vauthors=Dunham A, Matthews LH, Burton J, etal |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Li WJ, Hu N, Su H, etal |title=Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma. |journal=Oncogene |volume=22 |issue= 2 |pages= 314–8 |year= 2003 |pmid= 12527901 |doi= 10.1038/sj.onc.1206098 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Wieland I, Röpke A, Stumm M, etal |title=Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells. |journal=Oncol. Res. |volume=12 |issue= 11–12 |pages= 491–500 |year= 2002 |pmid= 11939413 |doi= }}
- {{cite journal |vauthors=Camargo AA, Nunes DN, Samaia HB, etal |title=Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12. |journal=Braz. J. Med. Biol. Res. |volume=34 |issue= 10 |pages= 1237–45 |year= 2002 |pmid= 11593297 |doi= 10.1590/s0100-879x2001001000002}}
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