| 词条 | Iodocyanopindolol |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 424908393 | IUPAC_name = (RS)-4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3-iodo-1H-indole-2-carbonitrile | image = 3-Iodocyanopindolol.svg | alt = Skeletal formula of iodocyanopindolol | image2 = Iodocyanopindolol-3D-spacefill.png | alt2 = Space-filling model of the iodocyanopindolol molecule | chirality = Racemic mixture | drug_name = | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 85124-14-7 | ATC_prefix = none | ATC_suffix = | ATC_supplemental = | PubChem = | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 73370 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | chemical_formula = | C=16 | H=20 | I=1 | N=3 | O=2 | molecular_weight = 413.25 g/mol | smiles = IC1=C(C#N)NC2=CC=CC(OCC(CNC(C)(C)C)O)=C21 }}Iodocyanopindolol (INN) is a drug related to pindolol which acts as both a β1 adrenoreceptor antagonist and a 5-HT1A receptor antagonist. Its 125I radiolabelled derivative has been widely used in mapping the distribution of beta adrenoreceptors in the body.[1] References1. ^{{cite journal |vauthors=Brodde OE, Karad K, Zerkowski HR, Rohm N, Reidemeister JC | title = Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding | journal = Circulation Research | year = 1983 | volume = 53 | issue = 6 | pages = 752–758 | pmid = 6139182 | doi=10.1161/01.res.53.6.752}} {{Beta blockers}}{{Adrenergic receptor modulators}}{{Serotonin receptor modulators}}{{Antihypertensive-stub}} 8 : 5-HT1A antagonists|Alcohols|Beta blockers|Iodoarenes|Indoles|Nitriles|Phenol ethers|Tert-butyl compounds |
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