| 词条 | Iofendylate |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 461935493 | IUPAC_name = ethyl 10-(4-iodophenyl)undecanoate | image = Iofendylate.png | drug_name = Iophendylate | tradename = Myodil, Pantopaque | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|CAS}} | CAS_number = 1320-11-2 | ATC_prefix = V08 | ATC_suffix = AD04 | PubChem = 7458 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB01187 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 7178 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 2990I809YH | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 951 | chemical_formula = | C=19 | H=29 | I=1 | O=2 | molecular_weight = 416.33683 | smiles = CCOC(=O)CCCCCCCCC(C)C1=CC=C(C=C1)I | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C19H29IO2/c1-3-22-19(21)11-9-7-5-4-6-8-10-16(2)17-12-14-18(20)15-13-17/h12-16H,3-11H2,1-2H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = LAYLQVBQIBQVLL-UHFFFAOYSA-N }} Iofendylate is a molecule that was used as a radiocontrast agent, typically for performing myelography studies. It was marketed under the trade names Pantopaque (in North America) and Myodil (rest of the world). Iofendylate is an iodobenzene (an iodinated oil-based substance) and as such it was recommended that the physician remove it from the patient at the end of the myelography study, which was a difficult and painful part of the procedure. Moreover, because complete removal could not always be achieved (or even attempted by some physicians), iofendylate's persistence in the body might sometimes lead to arachnoiditis, a potentially painful and debilitating lifelong disorder of the spine.[1][2] As a result, the substance, which was used extensively for over three decades, became the subject of multiple lawsuits filed around the world.[3] Iofendylate's use ceased when water-soluble agents suitable for spinal enhancement (such as metrizamide) became available in the late 1970s. With those substances it was no longer necessary to remove the contrast agent as it would eventually be absorbed into the body.[4] Also, with the advent of MRI, myelography studies are nowadays much less-frequently performed. See alsoMetrizamideReferences1. ^{{cite news|last1=Dunlevy|first1=Sue|title=Australians crippled and in chronic pain from dye used in toxic X-rays|url=http://www.dailytelegraph.com.au/lifestyle/health/australians-crippled-and-in-chronic-pain-from-dye-used-in-toxic-xrays/news-story/e35f258d50c2508c214809896673da88|accessdate=27 October 2017|work=The Daily Telegraph|date=10 December 2016}} 2. ^{{cite book|author1=William P. Dillon|author2=Christopher F. Dowd|title=Aminoff's Neurology and General Medicine|pages=1089–1105|edition=5th|chapter=Chapter 53 – Neurologic Complications of Imaging Procedures|date=2014|publisher=Elsevier Academic Press|isbn=978-0-12-407710-2}} 3. ^[https://books.google.com/books?id=wBqGbBvcOpsC&pg=PA119&lpg=PA119&dq=source=bl&ots=-cDaRWHyVP&sig=58GpVAui-B1ItfHr1Yp7K1kMx1c&hl=en&sa=X&ved=0ahUKEwj9zo_HsJPXAhXG6oMKHRNoBRU4ChDoAQgmMAE Myodil litigation] 4. ^{{cite journal |last1=Leeds |first1=NE |last2=Kieffer |first2=SA |title=Evolution of diagnostic neuroradiology from 1904 to 1999. |journal=Radiology |date=November 2000 |volume=217 |issue=2 |pages=309-18 |doi=10.1148/radiology.217.2.r00nv45309 |pmid=11058623 |url=https://pdfs.semanticscholar.org/8bfc/17f6ff7c70706ad0ad25b382558088463a2c.pdf}} External links
2 : Radiocontrast agents|Iodoarenes |
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