| 释义 |
- References
- Further reading
{{Infobox_gene}}Importin-7 is a protein that in humans is encoded by the IPO7 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.[2]
}}References1. ^{{cite journal |vauthors=Gorlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E | title = A novel class of RanGTP binding proteins | journal = J Cell Biol | volume = 138 | issue = 1 | pages = 65–80 |date=Aug 1997 | pmid = 9214382 | pmc = 2139951 | doi =10.1083/jcb.138.1.65 }}
2. ^1 {{cite web | title = Entrez Gene: IPO7 importin 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10527| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Jäkel S, Görlich D |title=Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells |journal=EMBO J. |volume=17 |issue= 15 |pages= 4491–4502 |year= 1998 |pmid= 9687515 |doi= 10.1093/emboj/17.15.4491 | pmc=1170780 }}
- {{cite journal | author=Paraskeva E |title=CRM1-mediated recycling of snurportin 1 to the cytoplasm |journal=J. Cell Biol. |volume=145 |issue= 2 |pages= 255–264 |year= 1999 |pmid= 10209022 |doi=10.1083/jcb.145.2.255 | pmc=2133107 |name-list-format=vanc| author2=Izaurralde E | author3=Bischoff FR | display-authors=3 | last4=Huber | first4=J | last5=Kutay | first5=U | last6=Hartmann | first6=E | last7=Lührmann | first7=R | last8=Görlich | first8=D }}
- {{cite journal | author=Jäkel S |title=The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1 |journal=EMBO J. |volume=18 |issue= 9 |pages= 2411–2423 |year= 1999 |pmid= 10228156 |doi= 10.1093/emboj/18.9.2411 | pmc=1171324 |name-list-format=vanc| author2=Albig W | author3=Kutay U | display-authors=3 | last4=Bischoff | first4=F.Ralf | last5=Schwamborn | first5=Klaus | last6=Doenecke | first6=Detlef | last7=Görlich | first7=Dirk }}
- {{cite journal |vauthors=Dean KA, von Ahsen O, Görlich D, Fried HM |title=Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin |journal=J. Cell Sci. |volume=114 |issue= Pt 19 |pages= 3479–85 |year= 2001 |pmid= 11682607 |doi= }}
- {{cite journal |vauthors=Bäuerle M, Doenecke D, Albig W |title=The requirement of H1 histones for a heterodimeric nuclear import receptor |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 32480–32489 |year= 2002 |pmid= 12080050 |doi= 10.1074/jbc.M202765200 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
- {{cite journal | author=Gevaert K |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–569 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |name-list-format=vanc| author2=Goethals M | author3=Martens L | display-authors=3 | last4=Van Damme | first4=Jozef | last5=Staes | first5=An | last6=Thomas | first6=Grégoire R. | last7=Vandekerckhove | first7=Joël }}
- {{cite journal | author=Fassati A |title=Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7 |journal=EMBO J. |volume=22 |issue= 14 |pages= 3675–3685 |year= 2003 |pmid= 12853482 |doi= 10.1093/emboj/cdg357 | pmc=165627 |name-list-format=vanc| author2=Görlich D | author3=Harrison I | display-authors=3 | last4=Zaytseva | first4=L | last5=Mingot | first5=JM }}
- {{cite journal | author=Bouwmeester T |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |name-list-format=vanc| author2=Bauch A | author3=Ruffner H | display-authors=3 | last4=Angrand | first4=Pierre-Olivier | last5=Bergamini | first5=Giovanna | last6=Croughton | first6=Karen | last7=Cruciat | first7=Cristina | last8=Eberhard | first8=Dirk | last9=Gagneur | first9=Julien }}
- {{cite journal |vauthors=King FW, Shtivelman E |title=Inhibition of nuclear import by the proapoptotic protein CC3 |journal=Mol. Cell. Biol. |volume=24 |issue= 16 |pages= 7091–7101 |year= 2004 |pmid= 15282309 |doi= 10.1128/MCB.24.16.7091-7101.2004 | pmc=479715 }}
- {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Rush J |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |name-list-format=vanc| author2=Moritz A | author3=Lee KA | display-authors=3 | last4=Guo | first4=Ailan | last5=Goss | first5=Valerie L | last6=Spek | first6=Erik J | last7=Zhang | first7=Hui | last8=Zha | first8=Xiang-Ming | last9=Polakiewicz | first9=Roberto D }}
- {{cite journal |vauthors=Kahle J, Baake M, Doenecke D, Albig W |title=Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13 |journal=Mol. Cell. Biol. |volume=25 |issue= 13 |pages= 5339–5354 |year= 2005 |pmid= 15964792 |doi= 10.1128/MCB.25.13.5339-5354.2005 | pmc=1157003 }}
- {{cite journal |vauthors=Arnold M, Nath A, Hauber J, Kehlenbach RH |title=Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1 |journal=J. Biol. Chem. |volume=281 |issue= 30 |pages= 20883–20890 |year= 2006 |pmid= 16704975 |doi= 10.1074/jbc.M602189200 }}
- {{cite journal |vauthors=Zaitseva L, Myers R, Fassati A |title=tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes |journal=PLoS Biol. |volume=4 |issue= 10 |pages= e332 |year= 2007 |pmid= 17020411 |doi= 10.1371/journal.pbio.0040332 | pmc=1584419 }}
- {{cite journal | author=Saijou E |title=Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms |journal=J. Biol. Chem. |volume=282 |issue= 44 |pages= 32327–32337 |year= 2007 |pmid= 17848547 |doi= 10.1074/jbc.M706793200 |name-list-format=vanc| author2=Itoh T | author3=Kim KW | display-authors=3 | last4=Iemura | first4=S.-i. | last5=Natsume | first5=T. | last6=Miyajima | first6=A. }}
{{refend}}{{gene-11-stub}} |