| 释义 |
- Function
- Cancer
- References
- Further reading
{{Infobox_gene}}Iroquois-class homeodomain protein IRX-2, also known as Iroquois homeobox protein 2, is a protein that in humans is encoded by the IRX2 gene.[1][2] Function IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[1] Cancer IRX2 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. [3] For this reason, IRX2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. [4] References1. ^1 {{cite web | title = Entrez Gene: iroquois homeobox 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=153572 | accessdate = }}
2. ^{{cite journal |vauthors=Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T | title = Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes | journal = Cytogenet. Cell Genet. | volume = 92 | issue = 3–4 | pages = 320–5 | year = 2001 | pmid = 11435706 | doi = 10.1159/000056921| url = }}
3. ^{{cite journal | vauthors = Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F | title = Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes. | journal = J Cell Physiol | volume = 230| issue = 4 | pages = 802–812 | date = April 2015 | pmid = 25205602 | doi = 10.1001/jamadermatol.2018.1373 }}
4. ^{{cite journal | vauthors = Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F | title = Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes. | journal = J Cell Physiol | volume = 230| issue = 4 | pages = 802–812 | date = April 2015 | pmid = 25205602 | doi = 10.1001/jamadermatol.2018.1373 }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Lam CY, Tam PO, Fan DS, etal |title=A genome-wide scan maps a novel high myopia locus to 5p15 |journal=Invest. Ophthalmol. Vis. Sci. |volume=49 |issue= 9 |pages= 3768–78 |year= 2008 |pmid= 18421076 |doi= 10.1167/iovs.07-1126 }}
- {{cite journal |vauthors=Cirulli ET, Kasperavičiūtė D, Attix DK, etal |title=Common genetic variation and performance on standardized cognitive tests |journal=European Journal of Human Genetics |volume= 18|issue= 7|pages= 815–20 |year= 2010 |pmid= 20125193 |pmc=2987367 |doi= 10.1038/ejhg.2010.2 }}
- {{cite journal |vauthors=Adamowicz M, Radlwimmer B, Rieker RJ, etal |title=Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas |journal=Genes Chromosomes Cancer |volume=45 |issue= 9 |pages= 829–38 |year= 2006 |pmid= 16752383 |doi= 10.1002/gcc.20343 }}
- {{cite journal |vauthors=Matsumoto K, Nishihara S, Kamimura M, etal |title=The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation |journal=Nat. Neurosci. |volume=7 |issue= 6 |pages= 605–12 |year= 2004 |pmid= 15133517 |doi= 10.1038/nn1249 }}
- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1996 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal |vauthors=Lewis MT, Ross S, Strickland PA, etal |title=Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast |journal=Cell Tissue Res. |volume=296 |issue= 3 |pages= 549–54 |year= 1999 |pmid= 10370142 |doi=10.1007/s004410051316 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 }}
{{refend}}{{NLM content}}{{Transcription factors|g3}}{{gene-5-stub}} |