词条 | Ischemic cell death |
释义 |
EtymologyAlthough ischemic cell death is the accepted name of the process, the alternative name of oncosis was introduced as the process involves the affected cell(s) swelling to an abnormally large size in known models. This is thought to be caused by failure of the plasma membrane's ionic pumps. The name oncosis (derived from ónkos, meaning largeness, and ónkosis, meaning swelling) was first introduced in 1910 by pathologist Friedrich Daniel von Recklinghausen.[6] Comparison to ApoptosisOncosis and apoptosis are distinct processes of cellular death. Oncosis is characterized by cellular swelling caused by a failure in ion pump function. Apoptosis, or programmed cell death involves a series of cell shrinking processes, beginning with cell size reduction and pyknosis, followed by cell budding and karyorrhexis, and phagocytosis by macrophages or neighboring cells due to size decrease.[7] The phagocytic disposal of apoptotic cells prevents the release of cellular debris that could induce an inflammatory response in neighboring cells.[8] In opposition, the leakage of cellular content associated with membrane disruption in oncosis often incites an inflammatory response in neighboring tissue, causing further cellular injury.[9] Additionally, apoptosis and the degradation of intracellular organelles is mediated by caspase activation, particularly caspase-3.[10] Oligonuclosomal DNA fragmentation is initiated by caspase-activated deoxyribonuclease following caspase-3 mediated cleavage of the enzyme’s inhibitor, ICAD.[11] In contrast, the oncotic pathway has been shown to be caspase-3 independent.[12] The primary determinant of cell death occurring via the oncotic or apoptotic pathway is cellular ATP levels.[13] Apoptosis is contingent upon ATP levels to form the energy dependent apoptosome.[14] A distinct biochemical event only seen in oncosis is the rapid depletion of intracellular ATP.[15] The lack of intracellular ATP results in a deactivation of sodium and potassium ATPase within the compromised cell membrane.[16] The lack of ion transport at the cell membrane leads to an accumulation of sodium and chloride ions within the cell with a concurrent water influx, contributing to the hallmark cellular swelling of oncosis.[17] As with apoptosis, oncosis has been shown to be genetically programmed and dependent on expression levels of uncoupling protein-2 (UCP-2) in HeLa cells. An increase in UCP-2 levels leads to a rapid decrease in mitochondrial membrane potential, reducing mitochondrial NADH and intracellular ATP levels, initiating the oncotic pathway.[18] The anti-apoptotic gene product Bcl-2 is not an active inhibitor of UCP-2 initiated cell death, further distinguishing oncosis and apoptosis as distinct cellular death mechanisms.[19] References1. ^Weerasinghe, Priya, and L. Maximilian Buja. "Oncosis: an important non-apoptotic mode of cell death." Experimental and molecular pathology 93.3 (2012): 302-308. 2. ^Weerasinghe, Priya, and L. Maximilian Buja. "Oncosis: an important non-apoptotic mode of cell death." Experimental and molecular pathology 93.3 (2012): 302-308. 3. ^Weerasinghe, Priya, and L. Maximilian Buja. "Oncosis: an important non-apoptotic mode of cell death." Experimental and molecular pathology 93.3 (2012): 302-308. 4. ^Weerasinghe, Priya, and L. Maximilian Buja. "Oncosis: an important non-apoptotic mode of cell death." Experimental and molecular pathology 93.3 (2012): 302-308. 5. ^Scarabelli, T. M., Knight, R., Stephanou, A., Townsend, P., Chen-Scarabelli, C., Lawrence, K., Gottlieb, R., Latchman, D., & Narula, J. (2006). Clinical implications of apoptosis in ischemic myocardium. Current problems in cardiology, 31(3), 181-264. 6. ^{{cite journal|last=Majno|author2=Joris|title=Apoptosis, oncosis, and necrosis. An overview of cell death.|journal=Am. J. Pathol.|year=1995|volume=146|issue=1|pages=1–2;16–19|pmid=7856735|pmc=1870771}} 7. ^Majno, G., & Joris, I. (1995). Apoptosis, oncosis, and necrosis. An overview of cell death. The American journal of pathology, 146(1), 3. 8. ^Ren, Y., & Savill, J. (1998). Apoptosis: the importance of being eaten. Cell Death & Differentiation, 5(7), 563-568. 9. ^Ren, Y., & Savill, J. (1998). Apoptosis: the importance of being eaten. Cell Death & Differentiation, 5(7), 563-568. 10. ^Earnshaw, W. C., Martins, L. M., & Kaufmann, S. H. (1999). Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annual review of biochemistry, 68(1), 383-424. 11. ^Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., & Nagata, S. (1998). A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature, 391(6662), 43-50. 12. ^Weerasinghe, Priya, and L. Maximilian Buja. "Oncosis: an important non-apoptotic mode of cell death." Experimental and molecular pathology 93.3 (2012): 302-308. 13. ^Eguchi Y, Shimizu S and Tsujimoto Y (1997) Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res. in press 14. ^Eguchi Y, Shimizu S and Tsujimoto Y (1997) Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res. in press 15. ^Yamamoto, N., Smith, M. W., Maki, A., Berezesky, I. K., & Trump, B. F. (1994). Role of cytosolic Ca2+ and protein kinases in the induction of the hsp70 gene. Kidney International, 45(4), 1093-1104. 16. ^Yamamoto, N., Smith, M. W., Maki, A., Berezesky, I. K., & Trump, B. F. (1994). Role of cytosolic Ca2+ and protein kinases in the induction of the hsp70 gene. Kidney International, 45(4), 1093-1104. 17. ^Yamamoto, N., Smith, M. W., Maki, A., Berezesky, I. K., & Trump, B. F. (1994). Role of cytosolic Ca2+ and protein kinases in the induction of the hsp70 gene. Kidney International, 45(4), 1093-1104. 18. ^Mills, E. M., Xu, D., Fergusson, M. M., Combs, C. A., Xu, Y., & Finkel, T. (2002). Regulation of cellular oncosis by uncoupling protein 2. Journal of Biological Chemistry, 277(30), 27385-27392. 19. ^Mills, E. M., Xu, D., Fergusson, M. M., Combs, C. A., Xu, Y., & Finkel, T. (2002). Regulation of cellular oncosis by uncoupling protein 2. Journal of Biological Chemistry, 277(30), 27385-27392. 2 : Biochemistry|Cell biology |
随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。