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词条 Isotonic hyponatremia
释义

  1. Pseudohyponatremia

  2. References

  3. External links

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}}Isotonic hyponatremia is a form of hyponatremia with mOsm measured between 280 and 295. It can be associated with pseudohyponatremia, or with isotonic infusion of glucose or mannitol.[1]

Pseudohyponatremia

Certain conditions, such as extraordinarily high blood levels of lipid (hyperlipidemia/hypertriglyceridemia) or protein (hyperparaproteinemia), magnify the electrolyte exclusion effect. This interferes with the measurement of serum sodium concentration by certain methods, leading to an erroneously low measurement of sodium, or pseudohyponatremia. The methods affected are the flame-photometric and indirect (but not direct) ion-selective electrode assays.[2][3] This is distinct from a true dilutional hyponatremia that can be caused by an osmotic shift of water from cells to the bloodstream after large infusions of mannitol or intravenous immunoglobulin.

It is associated with hyperlipidemia more frequently than with elevated protein.[4]

References

1. ^{{cite book | last1 = Gottschlich | first1 = Michele M. | last2 = Matarese | first2 = Laura E. | title = Contemporary nutrition support practice: a clinical guide | publisher=Saunders | location = Philadelphia | year = 2003 | pages = 130 | isbn = 0-7216-9357-1 | name-list-format = vanc }}
2. ^{{cite journal | vauthors = Weisberg LS | title = Pseudohyponatremia: a reappraisal | journal = The American Journal of Medicine | volume = 86 | issue = 3 | pages = 315–8 | date = Mar 1989 | pmid = 2645773 | doi = 10.1016/0002-9343(89)90302-1 }}
3. ^{{cite journal | vauthors = Nguyen MK, Ornekian V, Butch AW, Kurtz I | title = A new method for determining plasma water content: application in pseudohyponatremia | journal = American Journal of Physiology. Renal Physiology | volume = 292 | issue = 5 | pages = F1652–6 | date = May 2007 | pmid = 17299138 | doi = 10.1152/ajprenal.00493.2006 }}
4. ^{{cite journal | vauthors = Garibaldi BT, Cameron SJ, Choi M | title = Pseudohyponatremia in a patient with HIV and hepatitis C coinfection | journal = Journal of General Internal Medicine | volume = 23 | issue = 2 | pages = 202–5 | date = Feb 2008 | pmid = 17994269 | pmc = 2359164 | doi = 10.1007/s11606-007-0446-3 }}

External links

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}}{{Fluid, electrolyte, acid base metabolic pathology}}

1 : Electrolyte disturbances

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