ISSSC may refer to:

• Institute for the Study of Secularism in Society and Culture, an academic institution
• International Society for the Suppression of Savage Customs, a fictional society in the novel Heart of Darkness intended to mock the Berlin Conference

• Traffic (TV miniseries)
• Traffic victims
• Traffic violation
• Traffic wardens
• Traffic weaving
• Traffic with the Devil
• Traffic Zone Building
• Traffolite
• Trafford, Al
• Trafford Borough
• Trafford Center
• Trafford Centre Bus Station
• Trafford Centre tram stop
• Trafford Council election 1996
• Trafford F. C.
• Trafford F C
• Trafford, Greater Manchester
• Trafford local elections
• Trafford (metropolitan borough)
• Trafford Metropolitan Borough Council
• Trafford Park Aerodrome
• Trafford Park, Greater Manchester
• Trafford Park (stadium)
• Trafford Park station
• Trafford Park (Wroxham F.C)