| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Juxtaposed with another zinc finger protein 1 (JAZF1) also known as TAK1-interacting protein 27 (TIP27) or zinc finger protein 802 (ZNF802) is a protein that in humans is encoded by the JAZF1 gene.[1][2] Variants are associated with an increased risk of prostate cancer, an increased risk of type 2 diabetes, and an increased height.[3] Function This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized[2] References1. ^{{cite journal |vauthors=Adams MD, Soares MB, Kerlavage AR, Fields C, Venter JC | title = Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library | journal = Nat Genet | volume = 4 | issue = 4 | pages = 373–80 |date=Nov 1993 | pmid = 8401585 | pmc = | doi = 10.1038/ng0893-373 }}
2. ^1 {{cite web | title = Entrez Gene: JAZF1 JAZF zinc finger 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221895| accessdate = }}
3. ^{{ cite journal | author = Manolio TA | last2 = Guttmacher | first2 = Alan E. | last3 = Manolio | first3 = Teri A. | title = Genomewide Association Studies and Assessment of the Risk of Disease | journal = N Engl J Med |date=July 2010 | volume = 363 | issue = 2 | pmid = 20647212 | pages = 166–176 | doi = 10.1056/NEJMra0905980 }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Koontz JI, Soreng AL, Nucci M, etal |title=Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 11 |pages= 6348–53 |year= 2001 |pmid= 11371647 |doi= 10.1073/pnas.101132598 | pmc=33471 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Huang HY, Ladanyi M, Soslow RA |title=Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity |journal=Am. J. Surg. Pathol. |volume=28 |issue= 2 |pages= 224–32 |year= 2004 |pmid= 15043312 |doi=10.1097/00000478-200402000-00010 }}
- {{cite journal |vauthors=Nakajima T, Fujino S, Nakanishi G, etal |title=TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4 |journal=Nucleic Acids Res. |volume=32 |issue= 14 |pages= 4194–204 |year= 2004 |pmid= 15302918 |doi= 10.1093/nar/gkh741 | pmc=514368 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
- {{cite journal |vauthors=Micci F, Panagopoulos I, Bjerkehagen B, Heim S |title=Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma |journal=Cancer Res. |volume=66 |issue= 1 |pages= 107–12 |year= 2006 |pmid= 16397222 |doi= 10.1158/0008-5472.CAN-05-2485 }}
- {{cite journal |vauthors=Nucci MR, Harburger D, Koontz J, etal |title=Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms |journal=Am. J. Surg. Pathol. |volume=31 |issue= 1 |pages= 65–70 |year= 2007 |pmid= 17197920 |doi= 10.1097/01.pas.0000213327.86992.d1 }}
- {{cite journal |vauthors=Oliva E, de Leval L, Soslow RA, Herens C |title=High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by interphase FISH detection |journal=Am. J. Surg. Pathol. |volume=31 |issue= 8 |pages= 1277–84 |year= 2007 |pmid= 17667554 |doi= 10.1097/PAS.0b013e318031f012 }}
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