“JNJ-5207852”的意思、由来-开放百科全书

词条	JNJ-5207852
释义	References {{Chembox \| Verifiedfields = changed \| verifiedrevid = 461782074 \| ImageFile = JNJ-5207852.svg \| ImageSize = 230 \| PIN = 1-{3-[4-(Piperidin-1-ylmethyl)phenoxy]propyl}piperidine \| SystematicName = 1-({4-[3-(Piperidin-1-yl)propoxy]phenyl}methyl)piperidine \| Section1 = {{Chembox Identifiers \| IUPHAR_ligand = 1256 \| Abbreviations = JNJ-5207852 \| PubChem = 2766326 \| SMILES1 = O(c1ccc(cc1)CN2CCCCC2)CCCN3CCCCC3 \| ChemSpiderID = 2046959 \| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}} \| MeSHName = JNJ-5207852 \| ChEBI_Ref = {{ebicite\|changed\|EBI}} \| ChEBI = 312531 \| SMILES = O(c1ccc(cc1)CN2CCCCC2)CCCN3CCCCC3 \| ChEMBL_Ref = {{ebicite\|correct\|EBI}} \| ChEMBL = 129542 \| StdInChI_Ref = {{stdinchicite\|correct\|chemspider}} \| StdInChI = 1S/C20H32N2O/c1-3-12-21(13-4-1)16-7-17-23-20-10-8-19(9-11-20)18-22-14-5-2-6-15-22/h8-11H,1-7,12-18H2 \| StdInChIKey_Ref = {{stdinchicite\|correct\|chemspider}} \| StdInChIKey = PTKHFRNHJULJKT-UHFFFAOYSA-N}} \| Section2 = {{Chembox Properties \| Formula = C₂₀H₃₂N₂O \| MolarMass = 316.480 g/mol \| Appearance = \| Density = \| MeltingPt = \| BoilingPt = \| Solubility = \| Section3 = {{Chembox Hazards \| MainHazards = \| FlashPt = \| AutoignitionPt = }}JNJ-5207852 is a histamine antagonist selective for the H₃ subtype. It has stimulant and nootropic effects in animal studies,^[1] and has been suggested as a possible treatment for memory defects associated with epilepsy.^[2] JNJ-5207852 itself did not progress to clinical development due to poor pharmacokinetic characteristics, but the related compound JNJ-17216498 is currently in Phase II clinical trials for the treatment of narcolepsy.^[3] References 1. ^{{cite journal \|vauthors=Barbier AJ, Berridge C, Dugovic C, etal \|title=Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist \|journal=Br. J. Pharmacol. \|volume=143 \|issue=5 \|pages=649–61 \|date=November 2004 \|pmid=15466448 \|pmc=1575430 \|doi=10.1038/sj.bjp.0705964}} 2. ^Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E, Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K. Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice. Neuropharmacology. 2006 Mar;50(4):404-11. {{PMID\|16310812}} 3. ^{{cite journal \|vauthors=Esbenshade TA, Browman KE, Bitner RS, Strakhova M, Cowart MD, Brioni JD \|title=The histamine H3 receptor: an attractive target for the treatment of cognitive disorders \|journal=Br. J. Pharmacol. \|volume=154 \|issue=6 \|pages=1166–81 \|date=July 2008 \|pmid=18469850 \|doi=10.1038/bjp.2008.147 \|pmc=2483387}} {{Histaminergics}}{{pharma-stub}}{{organic-compound-stub}} 4 : H3 receptor antagonists\|Johnson & Johnson\|Phenol ethers\|Piperidines
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