| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Protein ajuba is a protein that in humans is encoded by the JUB gene.[1][2] Function JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment. Interactions JUB (gene) has been shown to interact with Stratifin[3] and SLC1A2.[4] References 1. ^{{cite journal | vauthors = Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD | title = Ajuba, a Novel LIM Protein, Interacts with Grb2, Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2- and Ras-Dependent Manner | journal = Mol Cell Biol | volume = 19 | issue = 6 | pages = 4379–89 | date = Jun 1999 | pmid = 10330178 | pmc = 104397 | doi = 10.1128/MCB.19.6.4379}}
2. ^{{cite web | title = Entrez Gene: JUB jub, ajuba homolog (Xenopus laevis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84962| accessdate = }}
3. ^{{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Mol. Cell. Proteomics | volume = 4 | issue = 6 | pages = 785–95 | date = Jun 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}
4. ^{{cite journal | vauthors = Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D | title = The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba | journal = Mol. Cell. Neurosci. | volume = 19 | issue = 2 | pages = 152–64 | date = Feb 2002 | pmid = 11860269 | doi = 10.1006/mcne.2001.1066 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Kanungo J, Pratt SJ, Marie H, Longmore GD | title = Ajuba, a Cytosolic LIM Protein, Shuttles into the Nucleus and Affects Embryonal Cell Proliferation and Fate Decisions | journal = Mol. Biol. Cell | volume = 11 | issue = 10 | pages = 3299–313 | year = 2000 | pmid = 11029037 | pmc = 14993 | doi = 10.1091/mbc.11.10.3299 }}
- {{cite journal | vauthors = Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D | title = The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba | journal = Mol. Cell. Neurosci. | volume = 19 | issue = 2 | pages = 152–64 | year = 2002 | pmid = 11860269 | doi = 10.1006/mcne.2001.1066 }}
- {{cite journal | vauthors = Marie H, Pratt SJ, Betson M, Epple H, Kittler JT, Meek L, Moss SJ, Troyanovsky S, Attwell D, Longmore GD, Braga VM | title = The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin | journal = J. Biol. Chem. | volume = 278 | issue = 2 | pages = 1220–8 | year = 2003 | pmid = 12417594 | doi = 10.1074/jbc.M205391200 }}
- {{cite journal | vauthors = Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, Saya H | title = Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells | journal = Cell | volume = 114 | issue = 5 | pages = 585–98 | year = 2003 | pmid = 13678582 | doi = 10.1016/S0092-8674(03)00642-1 }}
- {{cite journal | vauthors = Pratt SJ, Epple H, Ward M, Feng Y, Braga VM, Longmore GD | title = The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration | journal = J. Cell Biol. | volume = 168 | issue = 5 | pages = 813–24 | year = 2005 | pmid = 15728191 | pmc = 2171823 | doi = 10.1083/jcb.200406083 }}
- {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Mol. Cell. Proteomics | volume = 4 | issue = 6 | pages = 785–95 | year = 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}
- {{cite journal | vauthors = Kisseleva M, Feng Y, Ward M, Song C, Anderson RA, Longmore GD | title = The LIM Protein Ajuba Regulates Phosphatidylinositol 4,5-Bisphosphate Levels in Migrating Cells through an Interaction with and Activation of PIPKIα | journal = Mol. Cell. Biol. | volume = 25 | issue = 10 | pages = 3956–66 | year = 2005 | pmid = 15870270 | pmc = 1087706 | doi = 10.1128/MCB.25.10.3956-3966.2005 }}
- {{cite journal | vauthors = Feng Y, Longmore GD | title = The LIM Protein Ajuba Influences Interleukin-1-Induced NF-κB Activation by Affecting the Assembly and Activity of the Protein Kinase Cζ/p62/TRAF6 Signaling Complex | journal = Mol. Cell. Biol. | volume = 25 | issue = 10 | pages = 4010–22 | year = 2005 | pmid = 15870274 | pmc = 1087715 | doi = 10.1128/MCB.25.10.4010-4022.2005 }}
- {{cite journal | vauthors = Abe Y, Ohsugi M, Haraguchi K, Fujimoto J, Yamamoto T | title = LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis | journal = FEBS Lett. | volume = 580 | issue = 3 | pages = 782–8 | year = 2006 | pmid = 16413547 | doi = 10.1016/j.febslet.2005.12.096 }}
- {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
- {{cite journal | vauthors = Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA | title = TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours | journal = Mol. Cell. Endocrinol. | volume = 306 | issue = 1–2 | pages = 75–80 | year = 2008 | pmid = 19041365 | doi = 10.1016/j.mce.2008.10.043 }}
{{refend}}{{gene-14-stub}} |