“KCNIP2”的意思、由来-开放百科全书

Function

This gene encodes a member of the family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.^[3] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.^[2]

References

1. ^{{cite journal | vauthors = An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ | title = Modulation of A-type potassium channels by a family of calcium sensors | journal = Nature | volume = 403 | issue = 6769 | pages = 553–6 | date = Feb 2000 | pmid = 10676964 | pmc = | doi = 10.1038/35000592 }}
2. ^¹{{cite web | title = Entrez Gene: KCNIP2 Kv channel interacting protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30819| accessdate = }}
3. ^{{cite journal | vauthors = Burgoyne RD | title = Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling | journal = Nature Reviews. Neuroscience | volume = 8 | issue = 3 | pages = 182–93 | date = Mar 2007 | pmid = 17311005 | pmc = 1887812 | doi = 10.1038/nrn2093 }}

Further reading

{{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}

{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}

{{cite journal | vauthors = Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y | title = Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2 | journal = Biochemical and Biophysical Research Communications | volume = 282 | issue = 1 | pages = 96–102 | date = Mar 2001 | pmid = 11263977 | doi = 10.1006/bbrc.2001.4558 }}

{{cite journal | vauthors = Bähring R, Dannenberg J, Peters HC, Leicher T, Pongs O, Isbrandt D | title = Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 23888–94 | date = Jun 2001 | pmid = 11287421 | doi = 10.1074/jbc.M101320200 }}

{{cite journal | vauthors = Rosati B, Pan Z, Lypen S, Wang HS, Cohen I, Dixon JE, McKinnon D | title = Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle | journal = The Journal of Physiology | volume = 533 | issue = Pt 1 | pages = 119–25 | date = May 2001 | pmid = 11351020 | pmc = 2278594 | doi = 10.1111/j.1469-7793.2001.0119b.x }}

{{cite journal | vauthors = Decher N, Uyguner O, Scherer CR, Karaman B, Yüksel-Apak M, Busch AE, Steinmeyer K, Wollnik B | title = hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant | journal = Cardiovascular Research | volume = 52 | issue = 2 | pages = 255–64 | date = Nov 2001 | pmid = 11684073 | doi = 10.1016/S0008-6363(01)00374-1 }}

{{cite journal | vauthors = Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyêñ-Trân VT, Gu Y, Ikeda Y, Chu PH, Ross J, Giles WR, Chien KR | title = A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia | journal = Cell | volume = 107 | issue = 6 | pages = 801–13 | date = Dec 2001 | pmid = 11747815 | doi = 10.1016/S0092-8674(01)00588-8 }}

{{cite journal | vauthors = Deschênes I, DiSilvestre D, Juang GJ, Wu RC, An WF, Tomaselli GF | title = Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)? | journal = Circulation | volume = 106 | issue = 4 | pages = 423–9 | date = Jul 2002 | pmid = 12135940 | doi = 10.1161/01.CIR.0000025417.65658.B6 }}

{{cite journal | vauthors = Deschênes I, Tomaselli GF | title = Modulation of Kv4.3 current by accessory subunits | journal = FEBS Letters | volume = 528 | issue = 1-3 | pages = 183–8 | date = Sep 2002 | pmid = 12297301 | doi = 10.1016/S0014-5793(02)03296-9 }}

{{cite journal | vauthors = Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer JS | title = A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36445–54 | date = Sep 2003 | pmid = 12829703 | doi = 10.1074/jbc.M306142200 }}

{{cite journal | vauthors = Ren X, Shand SH, Takimoto K | title = Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide | journal = The Journal of Biological Chemistry | volume = 278 | issue = 44 | pages = 43564–70 | date = Oct 2003 | pmid = 12928444 | doi = 10.1074/jbc.M302337200 }}

{{cite journal | vauthors = Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA | title = Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5549–54 | date = Feb 2004 | pmid = 14623880 | doi = 10.1074/jbc.M311332200 }}

{{cite journal | vauthors = Kim LA, Furst J, Gutierrez D, Butler MH, Xu S, Goldstein SA, Grigorieff N | title = Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution | journal = Neuron | volume = 41 | issue = 4 | pages = 513–9 | date = Feb 2004 | pmid = 14980201 | doi = 10.1016/S0896-6273(04)00050-9 }}

{{cite journal | vauthors = Lin YL, Lin SR, Wu TT, Chang LS | title = Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins | journal = Biochemical and Biophysical Research Communications | volume = 319 | issue = 3 | pages = 720–4 | date = Jul 2004 | pmid = 15184042 | doi = 10.1016/j.bbrc.2004.05.064 }}

{{cite journal | vauthors = Rhodes KJ, Carroll KI, Sung MA, Doliveira LC, Monaghan MM, Burke SL, Strassle BW, Buchwalder L, Menegola M, Cao J, An WF, Trimmer JS | title = KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain | journal = The Journal of Neuroscience | volume = 24 | issue = 36 | pages = 7903–15 | date = Sep 2004 | pmid = 15356203 | doi = 10.1523/JNEUROSCI.0776-04.2004 }}

{{cite journal | vauthors = Lin YL, Chen CY, Cheng CP, Chang LS | title = Protein-protein interactions of KChIP proteins and Kv4.2 | journal = Biochemical and Biophysical Research Communications | volume = 321 | issue = 3 | pages = 606–10 | date = Aug 2004 | pmid = 15358149 | doi = 10.1016/j.bbrc.2004.07.006 }}

Function

See also

References

Further reading

External links