| 释义 |
- Function
- Interactions
- See also
- References
- Further reading
- External links
{{Infobox_gene}}ATP-sensitive inward rectifier potassium channel 12 is a protein that in humans is encoded by the KCNJ12 gene.[1][2][3][4] Function This gene encodes an inwardly rectifying K+ channel that may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels that contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17.[4] Interactions KCNJ12 has been shown to interact with: {{div col|colwidth=20em}}- APBA1,[6][7]
- CASK,[6][7]
- DLG1,[6][7][5]
- DLG2,[6]
- DLG3,[6]
- DLG4,[6][7]
- LIN7A[6][7]
- LIN7B,[6][7] and
- LIN7C.[6][7]
{{Div col end}} See also - Inward-rectifier potassium ion channel
References 1. ^{{cite journal | vauthors = Wible BA, De Biasi M, Majumder K, Taglialatela M, Brown AM | title = Cloning and functional expression of an inwardly rectifying K+ channel from human atrium | journal = Circulation Research | volume = 76 | issue = 3 | pages = 343–50 | date = Mar 1995 | pmid = 7859381 | pmc = | doi = 10.1161/01.res.76.3.343 }}
2. ^{{cite journal | vauthors = Kaibara M, Ishihara K, Doi Y, Hayashi H, Ehara T, Taniyama K | title = Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes | journal = FEBS Letters | volume = 531 | issue = 2 | pages = 250–4 | date = Nov 2002 | pmid = 12417321 | pmc = | doi = 10.1016/S0014-5793(02)03512-3 }}
3. ^{{cite journal | vauthors = Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA | title = International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 509–26 | date = Dec 2005 | pmid = 16382105 | pmc = | doi = 10.1124/pr.57.4.11 }}
4. ^1 {{cite web | title = Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3768| accessdate = }}
5. ^{{cite journal | vauthors = Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C | title = Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97 | journal = Journal of Cell Science | volume = 114 | issue = Pt 5 | pages = 987–98 | date = Mar 2001 | pmid = 11181181 | doi = }}
6. ^1 2 3 4 5 6 7 8 {{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 22331–46 | date = May 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}
7. ^1 2 3 4 5 6 {{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels | journal = The Journal of Biological Chemistry | volume = 279 | issue = 18 | pages = 19051–63 | date = Apr 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}
{{-}} Further reading {{refbegin | 2}}- {{cite journal | vauthors = Namba N, Inagaki N, Gonoi T, Seino Y, Seino S | title = Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2 | journal = FEBS Letters | volume = 386 | issue = 2–3 | pages = 211–4 | date = May 1996 | pmid = 8647284 | doi = 10.1016/0014-5793(96)00445-0 }}
- {{cite journal | vauthors = Hugnot JP, Pedeutour F, Le Calvez C, Grosgeorge J, Passage E, Fontes M, Lazdunski M | title = The human inward rectifying K+ channel Kir 2.2 (KCNJ12) gene: gene structure, assignment to chromosome 17p11.1, and identification of a simple tandem repeat polymorphism | journal = Genomics | volume = 39 | issue = 1 | pages = 113–6 | date = Jan 1997 | pmid = 9027495 | doi = 10.1006/geno.1996.4450 }}
- {{cite journal | vauthors = Gallagher PG, Forget BG | title = An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene | journal = The Journal of Biological Chemistry | volume = 273 | issue = 3 | pages = 1339–48 | date = Jan 1998 | pmid = 9430667 | doi = 10.1074/jbc.273.3.1339 }}
- {{cite journal | vauthors = Namba N, Mori R, Tanaka H, Kondo I, Narahara K, Seino Y | title = The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2-->p11.1 | journal = Cytogenetics and Cell Genetics | volume = 79 | issue = 1–2 | pages = 85–7 | year = 1998 | pmid = 9533018 | doi = 10.1159/000134688 }}
- {{cite journal | vauthors = Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C | title = Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97 | journal = Journal of Cell Science | volume = 114 | issue = Pt 5 | pages = 987–98 | date = Mar 2001 | pmid = 11181181 | doi = }}
- {{cite journal | vauthors = Preisig-Müller R, Schlichthörl G, Goerge T, Heinen S, Brüggemann A, Rajan S, Derst C, Veh RW, Daut J | title = Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 11 | pages = 7774–9 | date = May 2002 | pmid = 12032359 | pmc = 124349 | doi = 10.1073/pnas.102609499 }}
- {{cite journal | vauthors = Chen L, Kawano T, Bajic S, Kaziro Y, Itoh H, Art JJ, Nakajima Y, Nakajima S | title = A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 12 | pages = 8430–5 | date = Jun 2002 | pmid = 12034888 | pmc = 123084 | doi = 10.1073/pnas.122682899 }}
- {{cite journal | vauthors = Karkanis T, Li S, Pickering JG, Sims SM | title = Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery | journal = American Journal of Physiology. Heart and Circulatory Physiology | volume = 284 | issue = 6 | pages = H2325–34 | date = Jun 2003 | pmid = 12598232 | doi = 10.1152/ajpheart.00559.2002 }}
- {{cite journal | vauthors = Stonehouse AH, Grubb BD, Pringle JH, Norman RI, Stanfield PR, Brammar WJ | title = Nuclear immunostaining in rat neuronal cells using two anti-Kir2.2 ion channel polyclonal antibodies | journal = Journal of Molecular Neuroscience | volume = 20 | issue = 2 | pages = 189–94 | date = Apr 2003 | pmid = 12794312 | doi = 10.1385/JMN:20:2:189 }}
- {{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels | journal = The Journal of Biological Chemistry | volume = 279 | issue = 18 | pages = 19051–63 | date = Apr 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}
- {{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 22331–46 | date = May 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}
- {{cite journal | vauthors = Fang Y, Schram G, Romanenko VG, Shi C, Conti L, Vandenberg CA, Davies PF, Nattel S, Levitan I | title = Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2 | journal = American Journal of Physiology. Cell Physiology | volume = 289 | issue = 5 | pages = C1134–44 | date = Nov 2005 | pmid = 15958527 | doi = 10.1152/ajpcell.00077.2005 }}
- {{cite journal | vauthors = Kiesecker C, Zitron E, Scherer D, Lueck S, Bloehs R, Scholz EP, Pirot M, Kathöfer S, Thomas D, Kreye VA, Kiehn J, Borst MM, Katus HA, Schoels W, Karle CA | title = Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1 | journal = Journal of Molecular Medicine | volume = 84 | issue = 1 | pages = 46–56 | date = Jan 2006 | pmid = 16258766 | doi = 10.1007/s00109-005-0707-8 }}
{{refend}} External links - {{MeshName|Kir2.2+channel}}
{{NLM content}}{{Ion channels|g3}} 1 : Ion channels |