“KCNJ4”的意思、由来-开放百科全书

Function

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.^[1]

References

1. ^¹{{cite web | title = Entrez Gene: KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3761| accessdate = }}
2. ^{{cite journal | vauthors = Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C | title = Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97 | journal = J. Cell Sci. | volume = 114 | issue = Pt 5 | pages = 987–98 | date = March 2001 | pmid = 11181181 | doi = }}
3. ^{{cite journal | vauthors = Nehring RB, Wischmeyer E, Döring F, Veh RW, Sheng M, Karschin A | title = Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family | journal = J. Neurosci. | volume = 20 | issue = 1 | pages = 156–62 | date = January 2000 | pmid = 10627592 | doi = 10.1523/JNEUROSCI.20-01-00156.2000}}
4. ^{{cite journal | vauthors = Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y | title = Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 6 | pages = C1396–403 | date = June 2002 | pmid = 11997254 | doi = 10.1152/ajpcell.00615.2001 }}
5. ^{{cite journal | vauthors = Olsen O, Liu H, Wade JB, Merot J, Welling PA | title = Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 1 | pages = C183–95 | date = January 2002 | pmid = 11742811 | doi = 10.1152/ajpcell.00249.2001 }}
6. ^¹²{{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | date = May 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}
7. ^¹²³{{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels | journal = J. Biol. Chem. | volume = 279 | issue = 18 | pages = 19051–63 | date = April 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}

Further reading

{{cite journal | vauthors = Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA | title = International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. | journal = Pharmacol. Rev. | volume = 57 | issue = 4 | pages = 509–26 | year = 2006 | pmid = 16382105 | doi = 10.1124/pr.57.4.11 }}

{{cite journal | vauthors = Budarf ML, Périer F, Barnoski BL, Bell CJ, Vandenberg CA | title = Assignment of the human hippocampal inward rectifier potassium channel (HIR) gene to 22q13.1. | journal = Genomics | volume = 26 | issue = 3 | pages = 625–9 | year = 1995 | pmid = 7607694 | doi = 10.1016/0888-7543(95)80189-S }}

{{cite journal | vauthors = Périer F, Radeke CM, Vandenberg CA | title = Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 13 | pages = 6240–4 | year = 1994 | pmid = 8016146 | pmc = 44174 | doi = 10.1073/pnas.91.13.6240 }}

{{cite journal | vauthors = Tang W, Yang XC | title = Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes. | journal = FEBS Lett. | volume = 348 | issue = 3 | pages = 239–43 | year = 1994 | pmid = 8034048 | doi = 10.1016/0014-5793(94)00612-1 }}

{{cite journal | vauthors = Makhina EN, Kelly AJ, Lopatin AN, Mercer RW, Nichols CG | title = Cloning and expression of a novel human brain inward rectifier potassium channel. | journal = J. Biol. Chem. | volume = 269 | issue = 32 | pages = 20468–74 | year = 1994 | pmid = 8051145 | doi = }}

{{cite journal | vauthors = Cohen NA, Brenman JE, Snyder SH, Bredt DS | title = Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. | journal = Neuron | volume = 17 | issue = 4 | pages = 759–67 | year = 1996 | pmid = 8893032 | doi = 10.1016/S0896-6273(00)80207-X }}

{{cite journal | vauthors = Cohen NA, Sha Q, Makhina EN, Lopatin AN, Linder ME, Snyder SH, Nichols CG | title = Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits. | journal = J. Biol. Chem. | volume = 271 | issue = 50 | pages = 32301–5 | year = 1997 | pmid = 8943291 | doi = 10.1074/jbc.271.50.32301 }}

{{cite journal | vauthors = Zhu G, Qu Z, Cui N, Jiang C | title = Suppression of Kir2.3 activity by protein kinase C phosphorylation of the channel protein at threonine 53. | journal = J. Biol. Chem. | volume = 274 | issue = 17 | pages = 11643–6 | year = 1999 | pmid = 10206975 | doi = 10.1074/jbc.274.17.11643 }}

{{cite journal | vauthors = Kurschner C, Yuzaki M | title = Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. | journal = J. Neurosci. | volume = 19 | issue = 18 | pages = 7770–80 | year = 1999 | pmid = 10479680 | doi = 10.1523/JNEUROSCI.19-18-07770.1999}}

{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22. | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | year = 1999 | pmid = 10591208 | doi = 10.1038/990031 }}

{{cite journal | vauthors = Nehring RB, Wischmeyer E, Döring F, Veh RW, Sheng M, Karschin A | title = Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family. | journal = J. Neurosci. | volume = 20 | issue = 1 | pages = 156–62 | year = 2000 | pmid = 10627592 | doi = 10.1523/JNEUROSCI.20-01-00156.2000}}

{{cite journal | vauthors = Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C | title = Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97. | journal = J. Cell Sci. | volume = 114 | issue = Pt 5 | pages = 987–98 | year = 2001 | pmid = 11181181 | doi = }}

{{cite journal | vauthors = Liu Y, Liu D, Heath L, Meyers DM, Krafte DS, Wagoner PK, Silvia CP, Yu W, Curran ME | title = Direct activation of an inwardly rectifying potassium channel by arachidonic acid. | journal = Mol. Pharmacol. | volume = 59 | issue = 5 | pages = 1061–8 | year = 2001 | pmid = 11306688 | doi = 10.1124/mol.59.5.1061}}

{{cite journal | vauthors = Perillan PR, Chen M, Potts EA, Simard JM | title = Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brain. | journal = J. Biol. Chem. | volume = 277 | issue = 3 | pages = 1974–80 | year = 2002 | pmid = 11713246 | doi = 10.1074/jbc.M107984200 }}

{{cite journal | vauthors = Olsen O, Liu H, Wade JB, Merot J, Welling PA | title = Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex. | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 1 | pages = C183–95 | year = 2002 | pmid = 11742811 | doi = 10.1152/ajpcell.00249.2001 }}

{{cite journal | vauthors = Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y | title = Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses. | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 6 | pages = C1396–403 | year = 2002 | pmid = 11997254 | doi = 10.1152/ajpcell.00615.2001 }}

{{cite journal | vauthors = Preisig-Müller R, Schlichthörl G, Goerge T, Heinen S, Brüggemann A, Rajan S, Derst C, Veh RW, Daut J | title = Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 11 | pages = 7774–9 | year = 2002 | pmid = 12032359 | pmc = 124349 | doi = 10.1073/pnas.102609499 }}

{{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 26 | pages = 16899–903 | year = 2003 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}

{{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. | journal = J. Biol. Chem. | volume = 279 | issue = 18 | pages = 19051–63 | year = 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}

{{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | year = 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}

Function

Interactions

See also

References

Further reading

External links