“KCNJ8”的意思、由来-开放百科全书

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the K_ir6.1 protein.^[1] A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

1. ^¹{{cite web | title = Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3764| accessdate = }}

Further reading

{{cite journal | author=Kubo Y |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509–526 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11 |name-list-format=vanc| author2=Adelman JP | author3=Clapham DE | display-authors=3 | last4=Jan | first4=LY | last5=Karschin | first5=A | last6=Kurachi | first6=Y | last7=Lazdunski | first7=M | last8=Nichols | first8=CG | last9=Seino | first9=S }}

{{cite journal | author=Inagaki N |title=Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 5691–5694 |year= 1995 |pmid= 7890693 |doi=10.1074/jbc.270.11.5691 |name-list-format=vanc| author2=Tsuura Y | author3=Namba N | display-authors=3 | last4=Masuda | first4=K | last5=Gonoi | first5=T | last6=Horie | first6=M | last7=Seino | first7=Y | last8=Mizuta | first8=M | last9=Seino | first9=S }}

{{cite journal |vauthors=Inagaki N, Inazawa J, Seino S |title=cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8) |journal=Genomics |volume=30 |issue= 1 |pages= 102–104 |year= 1996 |pmid= 8595887 |doi= 10.1006/geno.1995.0018 }}

{{cite journal | author=Suzuki M |title=Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria |journal=Biochem. Biophys. Res. Commun. |volume=241 |issue= 3 |pages= 693–697 |year= 1998 |pmid= 9434770 |doi= 10.1006/bbrc.1997.7891 |name-list-format=vanc| author2=Kotake K | author3=Fujikura K | display-authors=3 | last4=Inagaki | first4=N | last5=Suzuki | first5=T | last6=Gonoi | first6=T | last7=Seino | first7=S | last8=Takata | first8=K }}

{{cite journal |vauthors=Erginel-Unaltuna N, Yang WP, Blanar MA |title=Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel |journal=Gene |volume=211 |issue= 1 |pages= 71–78 |year= 1998 |pmid= 9573340 |doi=10.1016/S0378-1119(98)00086-9 }}

{{cite journal | author=Surah-Narwal S |title=Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A |journal=Br. J. Pharmacol. |volume=128 |issue= 3 |pages= 667–672 |year= 1999 |pmid= 10516647 |doi= 10.1038/sj.bjp.0702862 | pmc=1571700 |name-list-format=vanc| author2=Xu SZ | author3=McHugh D | display-authors=3 | last4=McDonald | first4=R L | last5=Hough | first5=E | last6=Cheong | first6=A | last7=Partridge | first7=C | last8=Sivaprasadarao | first8=A | last9=Beech | first9=D J }}

{{cite journal |vauthors=Tucker SJ, Ashcroft FM |title=Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2 |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33393–33397 |year= 1999 |pmid= 10559219 |doi=10.1074/jbc.274.47.33393 }}

{{cite journal | author=Kono Y |title=The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A |journal=Pflügers Arch. |volume=440 |issue= 5 |pages= 692–698 |year= 2001 |pmid= 11007308 |doi=10.1007/s004240000315 |name-list-format=vanc| author2=Horie M | author3=Takano M | display-authors=3 | last4=Otani | first4=Hideo | last5=Xie | first5=Lai-Hua | last6=Akao | first6=M. | last7=Tsuji | first7=Keiko | last8=Sasayama | first8=Shigetake }}

{{cite journal |vauthors=Cui Y, Giblin JP, Clapp LH, Tinker A |title=A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 729–734 |year= 2001 |pmid= 11136227 |doi= 10.1073/pnas.011370498 | pmc=14656 }}

{{cite journal | author=Liu Y |title=Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels |journal=Mol. Pharmacol. |volume=59 |issue= 2 |pages= 225–30 |year= 2001 |pmid= 11160857 |doi= 10.1124/mol.59.2.225|name-list-format=vanc| author2=Ren G | author3=O'Rourke B | display-authors=3 | last4=Marbán | first4=E | last5=Seharaseyon | first5=J }}

{{cite journal |vauthors=Giblin JP, Cui Y, Clapp LH, Tinker A |title=Assembly limits the pharmacological complexity of ATP-sensitive potassium channels |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13717–13723 |year= 2002 |pmid= 11825905 |doi= 10.1074/jbc.M112209200 }}

{{cite journal | author=Vanoye CG |title=The carboxyl termini of K(ATP) channels bind nucleotides |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23260–23270 |year= 2002 |pmid= 11956191 |doi= 10.1074/jbc.M112004200 |name-list-format=vanc| author2=MacGregor GG | author3=Dong K | display-authors=3 | last4=Tang | first4=L | last5=Buschmann | first5=AS | last6=Hall | first6=AE | last7=Lu | first7=M | last8=Giebisch | first8=G | last9=Hebert | first9=SC }}

{{cite journal | author=Miki T |title=Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1 |journal=Nat. Med. |volume=8 |issue= 5 |pages= 466–472 |year= 2002 |pmid= 11984590 |doi= 10.1038/nm0502-466 |name-list-format=vanc| author2=Suzuki M | author3=Shibasaki T | display-authors=3 | last4=Uemura | first4=Hiroko | last5=Sato | first5=Toshiaki | last6=Yamaguchi | first6=Kaori | last7=Koseki | first7=Haruhiko | last8=Iwanaga | first8=Toshihiko | last9=Nakaya | first9=Haruaki }}

{{cite journal |vauthors=Nakamura K, Hirano J, Itazawa S, Kubokawa M |title=Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 4 |pages= F784–91 |year= 2002 |pmid= 12217870 |doi= 10.1152/ajprenal.00023.2002 }}

{{cite journal | author=Curley M |title=Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium |journal=Mol. Hum. Reprod. |volume=8 |issue= 10 |pages= 941–945 |year= 2003 |pmid= 12356945 |doi=10.1093/molehr/8.10.941 |name-list-format=vanc| author2=Cairns MT | author3=Friel AM | display-authors=3 | last4=McMeel | first4=OM | last5=Morrison | first5=JJ | last6=Smith | first6=TJ }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Singh H |title=Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes |journal=J. Mol. Cell. Cardiol. |volume=35 |issue= 5 |pages= 445–459 |year= 2004 |pmid= 12738227 |doi=10.1016/S0022-2828(03)00041-5 |name-list-format=vanc| author2=Hudman D | author3=Lawrence CL | display-authors=3 | last4=Rainbow | first4=RD | last5=Lodwick | first5=D | last6=Norman | first6=RI }}

{{cite journal | author=Insuk SO |title=Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells |journal=Int. J. Impot. Res. |volume=15 |issue= 4 |pages= 258–266 |year= 2003 |pmid= 12934053 |doi= 10.1038/sj.ijir.3901013 |name-list-format=vanc| author2=Chae MR | author3=Choi JW | display-authors=3 | last4=Yang | first4=D K | last5=Sim | first5=J H | last6=Lee | first6=S W }}

{{cite journal | author=Emanuele E |title=Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion |journal=Int. J. Mol. Med. |volume=12 |issue= 4 |pages= 509–12 |year= 2004 |pmid= 12964027 |doi= 10.3892/ijmm.12.4.509|name-list-format=vanc| author2=Falcone C | author3=Carabela M | display-authors=3 | last4=Minoretti | first4=P | last5=d'Angelo | first5=A | last6=Montagna | first6=L | last7=Geroldi | first7=D }}

{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

See also

References

Further reading

External links