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词条 KCNJ9
释义

  1. Function

  2. Interactions

  3. See also

  4. References

  5. Further reading

  6. External links

{{Infobox_gene}}G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.[1][2][3]

Function

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex.[3]

Interactions

KCNJ9 has been shown to interact with KCNJ6.[4][5]

See also

  • G protein-coupled inwardly-rectifying potassium channel
  • Inward-rectifier potassium ion channel

References

1. ^{{cite journal | vauthors = Lesage F, Fink M, Barhanin J, Lazdunski M, Mattéi MG | title = Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23 | journal = Genomics | volume = 29 | issue = 3 | pages = 808–9 | date = Oct 1995 | pmid = 8575783 | pmc = | doi = 10.1006/geno.1995.9928 }}
2. ^{{cite journal | vauthors = Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA | title = International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 509–26 | date = Dec 2005 | pmid = 16382105 | pmc = | doi = 10.1124/pr.57.4.11 }}
3. ^1 {{cite web | title = Entrez Gene: KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3765| accessdate = }}
4. ^{{cite journal | vauthors = Jelacic TM, Kennedy ME, Wickman K, Clapham DE | title = Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 46 | pages = 36211–6 | date = Nov 2000 | pmid = 10956667 | doi = 10.1074/jbc.M007087200 }}
5. ^{{cite journal | vauthors = Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH | title = G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase | journal = The Journal of Biological Chemistry | volume = 277 | issue = 48 | pages = 46010–9 | date = Nov 2002 | pmid = 12297500 | doi = 10.1074/jbc.M205035200 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Jelacic TM, Sims SM, Clapham DE | title = Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3 | journal = The Journal of Membrane Biology | volume = 169 | issue = 2 | pages = 123–9 | date = May 1999 | pmid = 10341034 | doi = 10.1007/s002329900524 }}
  • {{cite journal | vauthors = Schoots O, Wilson JM, Ethier N, Bigras E, Hebert TE, Van Tol HH | title = Co-expression of human Kir3 subunits can yield channels with different functional properties | journal = Cellular Signalling | volume = 11 | issue = 12 | pages = 871–83 | date = Dec 1999 | pmid = 10659995 | doi = 10.1016/S0898-6568(99)00059-5 }}
  • {{cite journal | vauthors = Vaughn J, Wolford JK, Prochazka M, Permana PA | title = Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3) | journal = Biochemical and Biophysical Research Communications | volume = 274 | issue = 2 | pages = 302–9 | date = Aug 2000 | pmid = 10913335 | doi = 10.1006/bbrc.2000.3136 }}
  • {{cite journal | vauthors = Jelacic TM, Kennedy ME, Wickman K, Clapham DE | title = Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 46 | pages = 36211–6 | date = Nov 2000 | pmid = 10956667 | doi = 10.1074/jbc.M007087200 }}
  • {{cite journal | vauthors = Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH | title = G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase | journal = The Journal of Biological Chemistry | volume = 277 | issue = 48 | pages = 46010–9 | date = Nov 2002 | pmid = 12297500 | doi = 10.1074/jbc.M205035200 }}
  • {{cite journal | vauthors = Plummer HK, Dhar MS, Cekanova M, Schuller HM | title = Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines | journal = BMC Cancer | volume = 5 | pages = 104 | year = 2006 | pmid = 16109170 | pmc = 1208863 | doi = 10.1186/1471-2407-5-104 }}
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External links

  • {{MeshName|KCNJ9+protein,+human}}
{{Ion channels|g3}}{{NLM content}}{{membrane-protein-stub}}

1 : Ion channels
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