| 释义 |
- Function
- See also
- References
- Further reading
{{Infobox_gene}}Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, also known as KCNN2, is a protein which in humans is encoded by the KCNN2 gene.[1] KCNN2 is an ion channel protein also known as KCa2.2.[2] Function Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The KCa2.2 protein is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. KCa2.2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This protein is a member of the calcium-activated potassium channel family. Two transcript variants encoding different isoforms have been found for the KCNN2 gene.[2]In a study SK2 (KCNN2) potassium channel was overexpressed in the basolateral amygdala using a herpes simplex viral system. This reduced anxiety and stress-induced corticosterone secretion at a systemic level. SK2 overexpression also reduced dendritic arborization of the amygdala neurons.[3] See also- SK channel
- Voltage-gated potassium channel
References1. ^{{cite journal |vauthors=Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H | title = International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels | journal = Pharmacol. Rev. | volume = 57 | issue = 4 | pages = 463–72 |date=December 2005 | pmid = 16382103 | doi = 10.1124/pr.57.4.9 | url = }}
2. ^1 {{cite web | title = Entrez Gene: KCNN2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3781| accessdate = }}
3. ^{{cite journal |vauthors=Mitra R, Ferguson D, Sapolsky RM | title = SK2 potassium channel over-expression in basolateral amygdala reduces anxiety, stress-induced corticosterone and dendritic arborization | journal = Mol. Psychiatry | volume = 14| issue = 9| pages = 847–55, 827|date=February 2009 | pmid = 19204724 | doi = 10.1038/mp.2009.9 | url = | pmc = 2763614 }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Wei AD, Gutman GA, Aldrich R, etal |title=International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 463–72 |year= 2006 |pmid= 16382103 |doi= 10.1124/pr.57.4.9 }}
- {{cite journal |vauthors=Jäger H, Adelman JP, Grissmer S |title=SK2 encodes the apamin-sensitive Ca2+-activated K+ channels in the human leukemic T cell line, Jurkat |journal=FEBS Lett. |volume=469 |issue= 2–3 |pages= 196–202 |year= 2000 |pmid= 10713270 |doi=10.1016/S0014-5793(00)01236-9 }}
- {{cite journal |vauthors=Liu QH, Williams DA, McManus C, etal |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832–7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697 | pmc=18318 }}
- {{cite journal |vauthors=Desai R, Peretz A, Idelson H, etal |title=Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 39954–63 |year= 2001 |pmid= 10991935 |doi= 10.1074/jbc.M001562200 }}
- {{cite journal |vauthors=Rimini R, Rimland JM, Terstappen GC |title=Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain |journal=Brain Res. Mol. Brain Res. |volume=85 |issue= 1–2 |pages= 218–20 |year= 2001 |pmid= 11146124 |doi=10.1016/S0169-328X(00)00255-2 }}
- {{cite journal |vauthors=Schumacher MA, Rivard AF, Bächinger HP, Adelman JP |title=Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin |journal=Nature |volume=410 |issue= 6832 |pages= 1120–4 |year= 2001 |pmid= 11323678 |doi= 10.1038/35074145 }}
- {{cite journal |vauthors=Miller MJ, Rauer H, Tomita H, etal |title=Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 27753–6 |year= 2001 |pmid= 11395478 |doi= 10.1074/jbc.C100221200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Piotrowska AP, Solari V, Puri P |title=Distribution of Ca2+-activated K channels, SK2 and SK3, in the normal and Hirschsprung's disease bowel |journal=J. Pediatr. Surg. |volume=38 |issue= 6 |pages= 978–83 |year= 2003 |pmid= 12778407 |doi=10.1016/S0022-3468(03)00138-6 }}
- {{cite journal |vauthors=Xu Y, Tuteja D, Zhang Z, etal |title=Molecular identification and functional roles of a Ca2+-activated K+ channel in human and mouse hearts |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49085–94 |year= 2004 |pmid= 13679367 |doi= 10.1074/jbc.M307508200 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Feranchak AP, Doctor RB, Troetsch M, etal |title=Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels |journal=Gastroenterology |volume=127 |issue= 3 |pages= 903–13 |year= 2004 |pmid= 15362045 |doi=10.1053/j.gastro.2004.06.047 }}
- {{cite journal |vauthors=Tajima N, Schönherr K, Niedling S, etal |title=Ca2+-activated K+ channels in human melanoma cells are up-regulated by hypoxia involving hypoxia-inducible factor-1α and the von Hippel-Lindau protein |journal=J. Physiol. |volume=571 |issue= Pt 2 |pages= 349–59 |year= 2006 |pmid= 16396931 |doi= 10.1113/jphysiol.2005.096818 | pmc=1796787 }}
- {{cite journal |vauthors=Lu L, Zhang Q, Timofeyev V, etal |title=Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2 |journal=Circ. Res. |volume=100 |issue= 1 |pages= 112–20 |year= 2007 |pmid= 17110593 |doi= 10.1161/01.RES.0000253095.44186.72 }}
- {{cite journal |vauthors=Morimoto T, Ohya S, Hayashi H, etal |title=Cell-cycle-dependent regulation of Ca2+-activated K+ channel in Jurkat T-lymphocyte |journal=J. Pharmacol. Sci. |volume=104 |issue= 1 |pages= 94–8 |year= 2007 |pmid= 17452806 |doi=10.1254/jphs.SC0070032 }}
- {{cite journal |vauthors=Dolga AM, Terpolilli N, Kepura F, etal |title=KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia |journal=Cell Death Dis. |volume= 2| issue= e147 |pages=e147 |year= 2011 |pmid= 21509037 |doi=10.1038/cddis.2011.30 |pmc=3122061}}
{{refend}}{{NLM content}}{{PDB Gallery|geneid=3781}}{{Ion channels|g3}}{{membrane-protein-stub}} 1 : Ion channels |