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词条 KDM4C
释义

  1. Function

  2. Model organisms

  3. References

  4. Further reading

{{Infobox_gene}}Lysine-specific demethylase 4C is an enzyme that in humans is encoded by the KDM4C gene.[1][2][3]

Function

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily. It functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.[3] A expressional decrease of KDM4C was found during cardiac differentation of murine embryonic stem cells.[4]

Model organisms

Model organisms have been used in the study of KDM4C function. A conditional knockout mouse line, called Kdm4ctm1a(KOMP)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty five tests were carried out on mutant mice and two significant abnormalities were observed.[8] Homozygous mutant males had decreased haematocrit and haemoglobin levels, while animals of both sex displayed an increase in sebaceous gland size.[8]

References

1. ^{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 5 | pages = 277–86 | date = Oct 1998 | pmid = 9872452 | pmc = | doi = 10.1093/dnares/5.5.277 }}
2. ^{{cite journal | vauthors = Katoh M, Katoh M | title = Identification and characterization of JMJD2 family genes in silico | journal = International Journal of Oncology | volume = 24 | issue = 6 | pages = 1623–8 | date = Jun 2004 | pmid = 15138608 | pmc = | doi = 10.3892/ijo.25.3.759 }}
3. ^1 {{cite web | title = Entrez Gene: JMJD2C jumonji domain containing 2C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23081| accessdate = }}
4. ^{{Cite journal|last=Boeckel|first=Jes-Niels|last2=Derlet|first2=Anja|last3=Glaser|first3=Simone F.|last4=Luczak|first4=Annika|last5=Lucas|first5=Tina|last6=Heumüller|first6=Andreas W.|last7=Krüger|first7=Marcus|last8=Zehendner|first8=Christoph M.|last9=Kaluza|first9=David|date=July 2016|title=JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells|journal=Arteriosclerosis, Thrombosis, and Vascular Biology|volume=36|issue=7|pages=1425–1433|doi=10.1161/ATVBAHA.116.307695|issn=1524-4636|pmid=27199445}}
5. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBXV/haematology-cbc/ |title=Haematology data for Kdm4c |publisher=Wellcome Trust Sanger Institute}}
6. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBXV/salmonella-challenge/ |title=Salmonella infection data for Kdm4c |publisher=Wellcome Trust Sanger Institute}}
7. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBXV/citrobacter-challenge/ |title=Citrobacter infection data for Kdm4c |publisher=Wellcome Trust Sanger Institute}}
8. ^1 2 3 {{cite journal | doi = 10.1111/j.1755-3768.2010.4142.x | title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice | year = 2010 | author = Gerdin AK | journal = Acta Ophthalmologica | volume = 88 | pages = 925–7 }}
9. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
10. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Kdm4c |title=International Knockout Mouse Consortium}}
11. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4362199 |title=Mouse Genome Informatics}}
12. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
13. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
14. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
15. ^{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Yang ZQ, Imoto I, Fukuda Y, Pimkhaokham A, Shimada Y, Imamura M, Sugano S, Nakamura Y, Inazawa J | title = Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines | journal = Cancer Research | volume = 60 | issue = 17 | pages = 4735–9 | date = Sep 2000 | pmid = 10987278 | doi = }}
  • {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
  • {{cite journal | vauthors = Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y | title = Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases | journal = Cell | volume = 125 | issue = 3 | pages = 467–81 | date = May 2006 | pmid = 16603238 | doi = 10.1016/j.cell.2006.03.028 }}
  • {{cite journal | vauthors = Cloos PA, Christensen J, Agger K, Maiolica A, Rappsilber J, Antal T, Hansen KH, Helin K | title = The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3 | journal = Nature | volume = 442 | issue = 7100 | pages = 307–11 | date = Jul 2006 | pmid = 16732293 | doi = 10.1038/nature04837 }}
  • {{cite journal | vauthors = Wissmann M, Yin N, Müller JM, Greschik H, Fodor BD, Jenuwein T, Vogler C, Schneider R, Günther T, Buettner R, Metzger E, Schüle R | title = Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression | journal = Nature Cell Biology | volume = 9 | issue = 3 | pages = 347–53 | date = Mar 2007 | pmid = 17277772 | doi = 10.1038/ncb1546 }}
  • {{cite journal | vauthors = Katoh Y, Katoh M | title = Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells | journal = International Journal of Molecular Medicine | volume = 20 | issue = 2 | pages = 269–73 | date = Aug 2007 | pmid = 17611647 | doi = 10.3892/ijmm.20.2.269 }}
  • {{cite journal | authors = Erhu Zhao, Jane Ding,.....Hongjuan Cui, Han-Fei Ding| title = KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism | journal = Cell Reports | volume = 14| issue = | pages = 506–519| date = 2016 | pmid = 26774480| doi = 10.1016/j.celrep.2015.12.053 | pmc=4731315}}
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