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词条 Kevin Downard
释义

  1. Education

  2. Career

  3. Honours and other service

  4. References

  5. External links

{{EngvarB|date=September 2014}}{{Use dmy dates|date=September 2014}}Kevin Downard is an Australian academic scientist whose research specialises in the improving responses to infectious disease through the application and development of mass spectrometry and other molecular approaches in the life and medical sciences. Downard has 30 years of experience in the field and written over 100 scientific publications and two books including a textbook[1] for the Royal Society of Chemistry and the first book to be published on the role of mass spectrometry in the study of protein interactions.[2]

Education

Downard was awarded his Ph.D. degree from the University of Adelaide in South Australia.

Career

Downard held a post-doctoral fellowship from 1991 at Massachusetts Institute of Technology (MIT), working with Klaus Biemann who pioneered protein sequencing by tandem mass spectrometry. He investigated subtleties of tandem mass spectra to help advance this application including the early implementation of electrospray ionization (ESI).[3] He remained at MIT as the Assistant Director of the National Institutes of Health Mass Spectrometry Research Resource before leading his own research laboratories in the United States and Australia over the past 20 years during which he has developed new mass spectrometry approaches to study protein structures and interactions to advance its application in biology and medicine.[4]

His laboratory was to first to demonstrate the preservation (in 1999)[5] of large macromolecular complexes on conventional Matrix-Assisted Laser Desorption Ionization (MALDI) targets, later described as Intensity fading MALDI mass spectrometry by others.[6] He also co-developed protein footprinting experiments employing radicals to study protein structures and was the first to apply the technique to study protein complexes.[7]

A major focus of his research is to arrest the impact of infectious disease and cancer causing viruses. He has developed new approaches to type, subtype,[8] study the lineage, antigenicity,[9] and evolution[10] of the influenza virus and other biopathogens, and has identified and investigated the molecular basis of new antiviral enzyme inhibitors, to help arrest the impact of infectious diseases on human health.

Honours and other service

Downard has been recognised by the American Society for Mass Spectrometry (ASMS) and has received four international fellowships from the Australian Academy of Sciences and the Japan Society for the Promotion of Science.{{citation needed|date=December 2018}} He convened and chaired the Sir Mark Oliphant Conference on Proteomics in 2003 and the largest biennial Australian mass spectrometry conference in 2009.{{citation needed|date=December 2018}} He has been active in promoting the importance of research in his field and the history of mass spectrometry and its pioneers[11] for which he received the Moran award from the Australian Academy of Science in 2006.{{citation needed|date=December 2018}} His activities have been highlighted in scientific journals in the analytical sciences, scientific web resources, and in the media including interviews with the Australian Broadcasting Corporation (ABC Australia). He has served on a range of national science and professional committees.

References

1. ^{{cite book|last1=Downard|first1=Kevin M.|title=Mass Spectrometry A Foundation Course|date=2004|publisher=Royal Society of Chemistry|location=Cambridge|doi=10.1039/9781847551306}}
2. ^{{cite book|last1=Downard|first1=Kevin M.|title=Mass Spectrometry of Protein Interactions|date=2007|publisher=Wiley-Interscience|location=Hoboken, N.J.|doi=10.1002/9780470146330}}
3. ^{{cite journal|last1=Downard|first1=Kevin M.|last2=Biemann|first2=Klaus|title=The effect of charge state and the localization of charge on the collision-induced dissociation of peptide ions|journal=Journal of the American Society for Mass Spectrometry|volume=5|issue=11|year=1994|pages=966–975|issn=1044-0305|doi=10.1016/1044-0305(94)80015-4}}
4. ^{{cite journal|last1=Downard|first1=Kevin M.|title=Ions of the interactome: The role of MS in the study of protein interactions in proteomics and structural biology|journal=Proteomics|volume=6|issue=20|year=2006|pages=5374–5384|issn=1615-9853|doi=10.1002/pmic.200600247}}
5. ^{{cite journal|last1=Kiselar|first1=Janna G.|last2=Downard|first2=Kevin M.|title=Direct Identification of Protein Epitopes by Mass Spectrometry without Immobilization of Antibody and Isolation of Antibody−Peptide Complexes|journal=Analytical Chemistry|volume=71|issue=9|year=1999|pages=1792–1801|issn=0003-2700|doi=10.1021/ac9811120}}
6. ^{{cite journal|last1=Downard|first1=Kevin M.|title=Indirect study of non-covalent protein complexes by MALDI mass spectrometry: Origins, advantages, and applications of the "intensity-fading" approach"|journal=Mass Spectrometry Reviews|volume=35|issue=5|year=2016|pages=559–573|doi=10.1002/mas.21480}}
7. ^{{cite journal|last1=Maleknia|first1=Simin D.|last2=Downard|first2=Kevin M.|title=Advances in Radical Probe Mass Spectrometry for Protein Footprinting in Chemical Biology Applications|journal=Chemical Society Reviews|date=March 2014|volume=43|issue=10|pages=3244–3258|doi=10.1039/C3CS60432B}}
8. ^{{cite journal|last1=Schwahn|first1=Alexander B.|last2=Wong|first2=Jason W. H.|last3=Downard|first3=Kevin M.|title=Subtyping of the Influenza Virus by High Resolution Mass Spectrometry|journal=Analytical Chemistry|date=May 2009|volume=81|issue=9|pages=3500–3506|doi=10.1021/ac900026f}}
9. ^{{cite journal|last1=Morrissey|first1=Bethny|last2=Downard|first2=Kevin M.|title=A proteomics approach to survey the antigenicity of the influenza virus by mass spectrometry|journal=Proteomics|date=April 2006|volume=6|issue=7|pages=2034–2041|doi=10.1002/pmic.200500642}}
10. ^{{cite journal|last1=Lun|first1=Aaron T.|last2=Swaminathan|first2=Kavya|last3=Wong|first3=Jason W.|last4=Downard|first4=Kevin M.|title=Mass trees: a new phylogenetic approach and algorithm to chart evolutionary history with mass spectrometry|journal=Analytical Chemistry|date=April 2013|volume=85|issue=11|pages=5475–5482|doi=10.1021/ac4005875}}
11. ^{{cite journal|last1=Downard|first1=Kevin|title=Historical Account: Francis William Aston: the man behind the mass spectrograph|journal=European Journal of Mass Spectrometry|date=2007|volume=13|issue=1|pages=177–90|doi=10.1255/ejms.878|pmid=17881785}}

External links

  • [https://research.unsw.edu.au/people/professor-kevin-downard Professor Kevin Downard | UNSW Research Gateway]
  • Downard Research Laboratory WWW Site : keVChem.com
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5 : Australian academics|Living people|University of New South Wales faculty|University of Adelaide alumni|Year of birth missing (living people)
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