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词条 KIF3B
释义

  1. Function

  2. Interactions

  3. Model organisms

  4. References

  5. Further reading

{{Infobox_gene}}Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene.[1][2]

Function

The protein encoded by this gene forms a heterotrimeric motor complex with kinesin family member 3A and KAP3 (kinesin accessory protein 3) to drive intra-flagellar transport and possibly to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. The heterotrimeric KIF3B/KIF3A/KAP3 motor protein is a member of the kinesin-2 subfamily of the kinesin superfamily.[2][3][4]

Interactions

KIF3B has been shown to interact with RAB4A.[5]

Model organisms

Model organisms have been used in the study of KIF3B function. A conditional knockout mouse line called Kif3btm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and female animals underwent a standardized phenotypic screen[7] to determine the effects of deletion.[8][9][10][11] Additional screens performed: - In-depth immunological phenotyping[12]{{clear|left}}

References

1. ^{{cite journal | vauthors = Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 4 | issue = 2 | pages = 141–50 | date = Apr 1997 | pmid = 9205841 | pmc = | doi = 10.1093/dnares/4.2.141 }}
2. ^1 {{cite web | title = Entrez Gene: KIF3B kinesin family member 3B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9371| accessdate = }}
3. ^{{cite journal | vauthors = Scholey JM | title = Kinesin-II, a membrane traffic motor in axons, axonemes, and spindles | journal = The Journal of Cell Biology | volume = 133 | issue = 1 | pages = 1–4 | date = Apr 1996 | pmid = 8601599 | pmc = 2120781 | doi = 10.1083/jcb.133.1.1 }}
4. ^{{cite journal | vauthors = Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L | title = A standardized kinesin nomenclature | journal = The Journal of Cell Biology | volume = 167 | issue = 1 | pages = 19–22 | date = Oct 2004 | pmid = 15479732 | pmc = 2041940 | doi = 10.1083/jcb.200408113 }}
5. ^{{cite journal | vauthors = Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM | title = Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin | journal = Molecular and Cellular Biology | volume = 23 | issue = 14 | pages = 4892–900 | date = Jul 2003 | pmid = 12832475 | pmc = 162221 | doi = 10.1128/MCB.23.14.4892-4900.2003 }}
6. ^{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}
7. ^1 {{cite web |url=http://www.mousephenotype.org/data/search?q=Kif3b#fq=**&facet=gene |title=International Mouse Phenotyping Consortium}}
8. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
9. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
10. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
11. ^{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022 | pmc=3717207}}
12. ^1 {{cite web |url= http://www.immunophenotyping.org/data/search?keys=Kif3b&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Yamazaki H, Nakata T, Okada Y, Hirokawa N | title = KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport | journal = The Journal of Cell Biology | volume = 130 | issue = 6 | pages = 1387–99 | date = Sep 1995 | pmid = 7559760 | pmc = 2120571 | doi = 10.1083/jcb.130.6.1387 }}
  • {{cite journal | vauthors = Nagata KI, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A | title = The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3 | journal = The EMBO Journal | volume = 17 | issue = 1 | pages = 149–58 | date = Jan 1998 | pmid = 9427749 | pmc = 1170366 | doi = 10.1093/emboj/17.1.149 }}
  • {{cite journal | vauthors = Shimizu K, Shirataki H, Honda T, Minami S, Takai Y | title = Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide | journal = The Journal of Biological Chemistry | volume = 273 | issue = 12 | pages = 6591–4 | date = Mar 1998 | pmid = 9506951 | doi = 10.1074/jbc.273.12.6591 }}
  • {{cite journal | vauthors = Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N | title = Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein | journal = Cell | volume = 95 | issue = 6 | pages = 829–37 | date = Dec 1998 | pmid = 9865700 | doi = 10.1016/S0092-8674(00)81705-5 }}
  • {{cite journal | vauthors = Navarro E, Espinosa L, Adell T, Torà M, Berrozpe G, Real FX | title = Expressed sequence tag (EST) phenotyping of HT-29 cells: cloning of ser/thr protein kinase EMK1, kinesin KIF3B, and of transcripts that include Alu repeated elements | journal = Biochimica et Biophysica Acta | volume = 1450 | issue = 3 | pages = 254–64 | date = Jul 1999 | pmid = 10395937 | doi = 10.1016/S0167-4889(99)00051-8 }}
  • {{cite journal | vauthors = Whitehead JL, Wang SY, Bost-Usinger L, Hoang E, Frazer KA, Burnside B | title = Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina | journal = Experimental Eye Research | volume = 69 | issue = 5 | pages = 491–503 | date = Nov 1999 | pmid = 10548469 | doi = 10.1006/exer.1999.0724 }}
  • {{cite journal | vauthors = Jimbo T, Kawasaki Y, Koyama R, Sato R, Takada S, Haraguchi K, Akiyama T | title = Identification of a link between the tumour suppressor APC and the kinesin superfamily | journal = Nature Cell Biology | volume = 4 | issue = 4 | pages = 323–7 | date = Apr 2002 | pmid = 11912492 | doi = 10.1038/ncb779 }}
  • {{cite journal | vauthors = Baker SA, Freeman K, Luby-Phelps K, Pazour GJ, Besharse JC | title = IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia | journal = The Journal of Biological Chemistry | volume = 278 | issue = 36 | pages = 34211–8 | date = Sep 2003 | pmid = 12821668 | doi = 10.1074/jbc.M300156200 }}
  • {{cite journal | vauthors = Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM | title = Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin | journal = Molecular and Cellular Biology | volume = 23 | issue = 14 | pages = 4892–900 | date = Jul 2003 | pmid = 12832475 | pmc = 162221 | doi = 10.1128/MCB.23.14.4892-4900.2003 }}
  • {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
  • {{cite journal | vauthors = Haraguchi K, Hayashi T, Jimbo T, Yamamoto T, Akiyama T | title = Role of the kinesin-2 family protein, KIF3, during mitosis | journal = The Journal of Biological Chemistry | volume = 281 | issue = 7 | pages = 4094–9 | date = Feb 2006 | pmid = 16298999 | doi = 10.1074/jbc.M507028200 }}
  • {{cite journal | vauthors = Wu Y, Dai XQ, Li Q, Chen CX, Mai W, Hussain Z, Long W, Montalbetti N, Li G, Glynne R, Wang S, Cantiello HF, Wu G, Chen XZ | title = Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin | journal = Human Molecular Genetics | volume = 15 | issue = 22 | pages = 3280–92 | date = Nov 2006 | pmid = 17008358 | doi = 10.1093/hmg/ddl404 }}
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