| 释义 |
- References
- Further reading
{{Infobox_gene}}DNA/RNA-binding protein KIN17 is a protein that in humans is encoded by the KIN gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.[2]
}}References1. ^{{cite journal |vauthors=Angulo JF, Rouer E, Mazin A, Mattei MG, Tissier A, Horellou P, Benarous R, Devoret R | title = Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein | journal = Nucleic Acids Res | volume = 19 | issue = 19 | pages = 5117–23 |date=Nov 1991 | pmid = 1923796 | pmc = 328864 | doi =10.1093/nar/19.19.5117 }}
2. ^1 {{cite web | title = Entrez Gene: KIN KIN, antigenic determinant of recA protein homolog (mouse)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22944| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Biard DS, Saintigny Y, Maratrat M, etal |title=Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin. |journal=Arch. Dermatol. Res. |volume=289 |issue= 8 |pages= 448–56 |year= 1997 |pmid= 9266022 |doi=10.1007/s004030050220 }}
- {{cite journal |vauthors=Kannouche P, Angulo JF |title=Overexpression of kin17 protein disrupts nuclear morphology and inhibits the growth of mammalian cells. |journal=J. Cell Sci. |volume=112 |issue= 19|pages= 3215–24 |year= 1999 |pmid= 10504327 |doi= }}
- {{cite journal |vauthors=Blattner C, Kannouche P, Litfin M, etal |title=UV-Induced stabilization of c-fos and other short-lived mRNAs. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3616–25 |year= 2000 |pmid= 10779351 |doi=10.1128/MCB.20.10.3616-3625.2000 | pmc=85654 }}
- {{cite journal |vauthors=Kannouche P, Mauffrey P, Pinon-Lataillade G, etal |title=Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans. |journal=Carcinogenesis |volume=21 |issue= 9 |pages= 1701–10 |year= 2000 |pmid= 10964102 |doi=10.1093/carcin/21.9.1701 }}
- {{cite journal |vauthors=Biard DS, Miccoli L, Despras E, etal |title=Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 19156–65 |year= 2002 |pmid= 11880372 |doi= 10.1074/jbc.M200321200 }}
- {{cite journal |vauthors=Miccoli L, Biard DS, Créminon C, Angulo JF |title=Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. |journal=Cancer Res. |volume=62 |issue= 19 |pages= 5425–35 |year= 2002 |pmid= 12359749 |doi= }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Masson C, Menaa F, Pinon-Lataillade G, etal |title=Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 616–21 |year= 2003 |pmid= 12525703 |doi= 10.1073/pnas.0236176100 | pmc=141045 }}
- {{cite journal |vauthors=Despras E, Miccoli L, Créminon C, etal |title=Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells. |journal=Radiat. Res. |volume=159 |issue= 6 |pages= 748–58 |year= 2003 |pmid= 12751957 |doi=10.1667/0033-7587(2003)159[0748:DOKAHD]2.0.CO;2 | issn=0033-7587 }}
- {{cite journal |vauthors=Biard DS, Miccoli L, Despras E, etal |title=Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes |journal=Mol. Cancer Res. |volume=1 |issue= 7 |pages= 519–31 |year= 2004 |pmid= 12754299 |doi= }}
- {{cite journal |vauthors=Miccoli L, Biard DS, Frouin I, etal |title=Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner |journal=Nucleic Acids Res. |volume=31 |issue= 14 |pages= 4162–75 |year= 2003 |pmid= 12853634 |doi=10.1093/nar/gkg459 | pmc=165974 }}
- {{cite journal |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
- {{cite journal |vauthors=Miccoli L, Frouin I, Novac O, etal |title=The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins |journal=Mol. Cell. Biol. |volume=25 |issue= 9 |pages= 3814–30 |year= 2005 |pmid= 15831485 |doi= 10.1128/MCB.25.9.3814-3830.2005 | pmc=1084281 }}
- {{cite journal |vauthors=le Maire A, Schiltz M, Braud S, etal |title=Crystallization and halide phasing of the C-terminal domain of human KIN17 |journal=Acta Crystallographica Section F |volume=62 |issue= Pt 3 |pages= 245–8 |year= 2006 |pmid= 16511313 |doi= 10.1107/S174430910600409X | pmc=2197188 }}
- {{cite journal |vauthors=le Maire A, Schiltz M, Stura EA, etal |title=A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics |journal=J. Mol. Biol. |volume=364 |issue= 4 |pages= 764–76 |year= 2007 |pmid= 17045609 |doi= 10.1016/j.jmb.2006.09.033 }}
{{refend}}{{PDB Gallery|geneid=22944}}{{gene-10-stub}} |