| 词条 | KLF13 |
| 释义 |
There is some evidence for KLF13 having a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been associated with obesity and orexigenic processes.[3] Ghrelin levels also positively correlated with methylation levels of cg07814318.[3] Moreover, expression levels of KLF13 were decreased and increased in the brains of starved and obese mice, respectively.[3] FunctionKLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.[1][4] KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1.[5] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.[5][6][7][8][9][10][11] InteractionsKLF13 has been shown to interact with CREB-binding protein,[12] Heat shock protein 47[12] and PCAF.[12] See also
References1. ^1 {{cite web | title = Entrez Gene: KLF13 Kruppel-like factor 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51621| accessdate = }} 2. ^{{cite journal | vauthors = Cook T, Gebelein B, Urrutia R | title = Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors | journal = Annals of the New York Academy of Sciences | volume = 880 | issue = 1 CELL AND MOLE | pages = 94–102 | date = Jun 1999 | pmid = 10415854 | doi = 10.1111/j.1749-6632.1999.tb09513.x }} 3. ^1 2 {{cite journal | vauthors = Wiemerslage L, Islam R, van der Kamp C, Cao H, Olivo G, Ence-Eriksson F, Castillo S, Larsen AL, Bandstein M, Dahlberg LS, Perland E, Gustavsson V, Nilsson J, Vogel H, Schürmann A, Larsson EM, Rask-Andersen M, Benedict C, Schiöth HB | title = A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels. | journal = Int J Obes (Lond) | volume = 43 | issue = 6 | pages = 990–994 | date = 14 Feb 2017 | pmid = 28194012 | doi = 10.1038/ijo.2017.43 }} 4. ^{{cite journal | vauthors = Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C | title = Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family | journal = Genomics | volume = 70 | issue = 1 | pages = 93–101 | date = Nov 2000 | pmid = 11087666 | doi = 10.1006/geno.2000.6362 }} 5. ^1 2 {{cite journal | vauthors = Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM | title = RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes | journal = Immunity | volume = 10 | issue = 1 | pages = 93–103 | date = Jan 1999 | pmid = 10023774 | doi = 10.1016/S1074-7613(00)80010-2 }} 6. ^{{cite journal | vauthors = Song A, Nikolcheva T, Krensky AM | title = Transcriptional regulation of RANTES expression in T lymphocytes | journal = Immunological Reviews | volume = 177 | issue = 1 | pages = 236–45 | date = Oct 2000 | pmid = 11138780 | doi = 10.1034/j.1600-065X.2000.17610.x }} 7. ^{{cite journal | vauthors = Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM | title = A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes | journal = The Journal of Clinical Investigation | volume = 110 | issue = 1 | pages = 119–26 | date = Jul 2002 | pmid = 12093895 | pmc = 151028 | doi = 10.1172/JCI15336 }} 8. ^{{cite journal | vauthors = Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM | title = Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30055–65 | date = Aug 2002 | pmid = 12050170 | doi = 10.1074/jbc.M204278200 }} 9. ^{{cite journal | vauthors = Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM | title = Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo | journal = Journal of Immunology | volume = 178 | issue = 9 | pages = 5496–504 | date = May 2007 | pmid = 17442931 | pmc = 2664650 | doi = 10.4049/jimmunol.178.9.5496 }} 10. ^{{cite journal | vauthors = Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM | title = Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription | journal = Journal of Immunology | volume = 178 | issue = 11 | pages = 7081–7 | date = Jun 2007 | pmid = 17513757 | pmc = 2674583 | doi = 10.4049/jimmunol.178.11.7081 }} 11. ^{{cite journal | vauthors = Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM | title = Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes | journal = Molecular and Cellular Biology | volume = 27 | issue = 1 | pages = 253–66 | date = Jan 2007 | pmid = 17074812 | pmc = 1800668 | doi = 10.1128/MCB.01071-06 }} 12. ^1 2 {{cite journal | vauthors = Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G |authorlink5=George Stamatoyannopoulos | title = Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7029–36 | date = Mar 2002 | pmid = 11748222 | pmc = 2808425 | doi = 10.1074/jbc.M108826200 }} Further reading{{refbegin | 2}}
External links
1 : Transcription factors |
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