| 释义 |
- Interactions
- References
- Further reading
- External links
{{Infobox_gene}}Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene.[1]KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.[2] Interactions KLF8 has been shown to interact with CTBP2.[3] References 1. ^{{cite web | title = Entrez Gene: KLF8 Kruppel-like factor 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11279| accessdate = }}
2. ^{{cite web| url=https://mcb.asm.org/content/33/15/2976#sec-22|title=Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing|website=asm.org|accessdate=12 January 2019|author=Alister P. W. Funnell |display-authors=etal}}
3. ^{{cite journal | vauthors = van Vliet J, Turner J, Crossley M | title = Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription | journal = Nucleic Acids Research | volume = 28 | issue = 9 | pages = 1955–62 | date = May 2000 | pmid = 10756197 | pmc = 103308 | doi = 10.1093/nar/28.9.1955 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = van Vliet J, Turner J, Crossley M | title = Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription | journal = Nucleic Acids Research | volume = 28 | issue = 9 | pages = 1955–62 | date = May 2000 | pmid = 10756197 | pmc = 103308 | doi = 10.1093/nar/28.9.1955 }}
- {{cite journal | vauthors = Lossi AM, Laugier-Anfossi F, Depetris D, Gecz J, Gedeon A, Kooy F, Schwartz C, Mattei MG, Croquette MF, Villard L | title = Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation | journal = Journal of Medical Genetics | volume = 39 | issue = 2 | pages = 113–7 | date = Feb 2002 | pmid = 11836360 | pmc = 1735036 | doi = 10.1136/jmg.39.2.113 }}
- {{cite journal | vauthors = Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M | title = The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 15 | pages = 12786–95 | date = Apr 2003 | pmid = 12556451 | doi = 10.1074/jbc.M300587200 }}
- {{cite journal | vauthors = Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL | title = Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression | journal = Molecular Cell | volume = 11 | issue = 6 | pages = 1503–15 | date = Jun 2003 | pmid = 12820964 | doi = 10.1016/S1097-2765(03)00179-5 }}
- {{cite journal | vauthors = Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA | title = A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element | journal = Blood Cells, Molecules & Diseases | volume = 35 | issue = 2 | pages = 227–35 | year = 2006 | pmid = 16023392 | doi = 10.1016/j.bcmd.2005.04.009 }}
- {{cite journal | vauthors = Wang X, Zhao J | title = KLF8 transcription factor participates in oncogenic transformation | journal = Oncogene | volume = 26 | issue = 3 | pages = 456–61 | date = Jan 2007 | pmid = 16832343 | doi = 10.1038/sj.onc.1209796 }}
- {{cite journal | vauthors = Hu JH, Navas P, Cao H, Stamatoyannopoulos G, Song CZ |authorlink4=George Stamatoyannopoulos | title = Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation | journal = Journal of Molecular Biology | volume = 366 | issue = 4 | pages = 1064–73 | date = Mar 2007 | pmid = 17224162 | pmc = 1907364 | doi = 10.1016/j.jmb.2006.12.047 }}
- {{cite journal | vauthors = Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J | title = Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion | journal = Cancer Research | volume = 67 | issue = 15 | pages = 7184–93 | date = Aug 2007 | pmid = 17671186 | doi = 10.1158/0008-5472.CAN-06-4729 }}
{{refend}} External links - {{MeshName|KLF8+protein,+human|3=KLF8 protein, human}}
{{Transcription factors|g2}}{{gene-X-stub}} 1 : Transcription factors |