| 释义 |
- References
- Further reading
- External links
{{Infobox_gene}}Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.[1][2][3][4][5]{{PBB Summary
| section_title =
| summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms.[5]
}}References1. ^{{cite journal |vauthors=Yousef GM, Scorilas A, Jung K, Ashworth LK, Diamandis EP | title = Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer | journal = J Biol Chem | volume = 276 | issue = 1 | pages = 53–61 |date=Feb 2001 | pmid = 11010966 | pmc = | doi = 10.1074/jbc.M005432200 }}
2. ^{{cite journal |vauthors=Yousef GM, Scorilas A, Magklara A, Memari N, Ponzone R, Sismondi P, Biglia N, Abd Ellatif M, Diamandis EP | title = The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer | journal = Br J Cancer | volume = 87 | issue = 11 | pages = 1294–300 |date=Nov 2002 | pmid = 12439720 | pmc = 2408911 | doi = 10.1038/sj.bjc.6600590 }}
3. ^{{cite journal |vauthors=Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM | title = A comprehensive nomenclature for serine proteases with homology to tissue kallikreins | journal = Biol Chem | volume = 387 | issue = 6 | pages = 637–41 |date=Jun 2006 | pmid = 16800724 | pmc = | doi = 10.1515/BC.2006.082 | url =https://epub.ub.uni-muenchen.de/17786/1/bc.2006.082.pdf }}
4. ^{{cite journal | title = Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005 | journal = Biol Chem | volume = 387 | issue = 6 | pages = 635–824 |date=Jun 2006 | pmid = 16800723 | pmc = | doi = 10.1515/BC.2006.081 | last1 = Diamandis | first1 = Eleftherios P. | last2 = Deperthes | first2 = David | last3 = Lundwall | first3 = Åke }}
5. ^1 {{cite web | title = Entrez Gene: KLK15 kallikrein-related peptidase 15| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55554| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Diamandis EP, Yousef GM, Luo LY, etal |title=The new human kallikrein gene family: implications in carcinogenesis |journal=Trends Endocrinol. Metab. |volume=11 |issue= 2 |pages= 54–60 |year= 2001 |pmid= 10675891 |doi= 10.1016/S1043-2760(99)00225-8}}
- {{cite journal |vauthors=Diamandis EP, Yousef GM |title=Human tissue kallikrein gene family: a rich source of novel disease biomarkers |journal=Expert Rev. Mol. Diagn. |volume=1 |issue= 2 |pages= 182–90 |year= 2002 |pmid= 11901813 |doi= 10.1586/14737159.1.2.182 }}
- {{cite journal |vauthors=Dihanich M, Spiess M |title=A novel serine proteinase-like sequence from human brain |journal=Biochim. Biophys. Acta |volume=1218 |issue= 2 |pages= 225–8 |year= 1994 |pmid= 8018728 |doi= 10.1016/0167-4781(94)90018-3}}
- {{cite journal |vauthors=Yousef GM, Chang A, Scorilas A, Diamandis EP |title=Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4 |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 1 |pages= 125–33 |year= 2000 |pmid= 11006094 |doi= 10.1006/bbrc.2000.3448 }}
- {{cite journal |vauthors=Gan L, Lee I, Smith R, etal |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region |journal=Gene |volume=257 |issue= 1 |pages= 119–30 |year= 2001 |pmid= 11054574 |doi=10.1016/S0378-1119(00)00382-6 }}
- {{cite journal |vauthors=Takayama TK, Carter CA, Deng T |title=Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR |journal=Biochemistry |volume=40 |issue= 6 |pages= 1679–87 |year= 2001 |pmid= 11327827 |doi=10.1021/bi002129r }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Yousef GM, Scorilas A, Katsaros D, etal |title=Prognostic value of the human kallikrein gene 15 expression in ovarian cancer |journal=J. Clin. Oncol. |volume=21 |issue= 16 |pages= 3119–26 |year= 2003 |pmid= 12915603 |doi= 10.1200/JCO.2003.09.111 }}
- {{cite journal |vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 | pmc=395752 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
{{refend}}External links- The MEROPS online database for peptidases and their inhibitors: S01.081
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