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词条 KLRG1
释义

  1. Function

  2. References

  3. Further reading

  4. External links

{{Infobox_gene}}Killer cell lectin-like receptor subfamily G member 1 is a protein that in humans is encoded by the KLRG1 gene.[1][2][3][4]

Function

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules.

KLRG1 is a lymphocyte co-inhibitory, or immune checkpoint, receptor expressed predominantly on late-differentiated effector and effector memory CD8+ T and NK cells. Its ligands are E-cadherin and N-cadherin with similar affinities,[7] respective markers of epithelial and mesenchymal cells.[8] Targeting of other co-inhibitory receptors for applications in oncology has gained widespread interest[9][10][11] (e.g., CTLA-4, PD-1, and its ligand PD-L1). Unlike the obvious enhanced immune activation present in CTLA-4 and PD-1 gene knockout mice,[12][13] KLRG1 knockout mice initially were found to have no abnormal features,[14] though were subsequently found to have enhanced immunity in a tuberculosis challenge model.[15]

The characterization of KLRG1 as a “senescent” marker, but other co-inhibitory receptors as “exhaustion” markers,[16][17][18] has contributed to relatively fewer studies on this molecule.

References

1. ^1 {{cite journal | vauthors = Hanke T, Corral L, Vance RE, Raulet DH | title = 2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells | journal = European Journal of Immunology | volume = 28 | issue = 12 | pages = 4409–17 | date = December 1998 | pmid = 9862378 | pmc = | doi = 10.1002/(SICI)1521-4141(199812)28:12<4409::AID-IMMU4409>3.0.CO;2-3 }}
2. ^1 {{cite journal | vauthors = Butcher S, Arney KL, Cook GP | title = MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells | journal = European Journal of Immunology | volume = 28 | issue = 11 | pages = 3755–62 | date = November 1998 | pmid = 9842918 | pmc = | doi = 10.1002/(SICI)1521-4141(199811)28:11<3755::AID-IMMU3755>3.0.CO;2-3 }}
3. ^1 {{cite journal | vauthors = Ito M, Maruyama T, Saito N, Koganei S, Yamamoto K, Matsumoto N | title = Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity | journal = The Journal of Experimental Medicine | volume = 203 | issue = 2 | pages = 289–95 | date = February 2006 | pmid = 16461340 | pmc = 2118217 | doi = 10.1084/jem.20051986 }}
4. ^1 {{cite journal | vauthors = Thimme R, Appay V, Koschella M, Panther E, Roth E, Hislop AD, Rickinson AB, Rowland-Jones SL, Blum HE, Pircher H | title = Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation | journal = Journal of Virology | volume = 79 | issue = 18 | pages = 12112–6 | date = September 2005 | pmid = 16140789 | pmc = 1212638 | doi = 10.1128/JVI.79.18.12112-12116.2005 }}
5. ^1 {{cite journal | vauthors = Nakamura S, Kuroki K, Ohki I, Sasaki K, Kajikawa M, Maruyama T, Ito M, Kameda Y, Ikura M, Yamamoto K, Matsumoto N, Maenaka K | title = Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1) | journal = The Journal of Biological Chemistry | volume = 284 | issue = 40 | pages = 27327–35 | date = October 2009 | pmid = 19654330 | pmc = 2785660 | doi = 10.1074/jbc.M109.038802 }}
6. ^1 {{cite journal | vauthors = Rosshart S, Hofmann M, Schweier O, Pfaff AK, Yoshimoto K, Takeuchi T, Molnar E, Schamel WW, Pircher H | title = Interaction of KLRG1 with E-cadherin: new functional and structural insights | journal = European Journal of Immunology | volume = 38 | issue = 12 | pages = 3354–64 | date = December 2008 | pmid = 19009530 | doi = 10.1002/eji.200838690 }}
7. ^1 {{cite journal | vauthors = Pauken KE, Wherry EJ | title = Overcoming T cell exhaustion in infection and cancer | journal = Trends in Immunology | volume = 36 | issue = 4 | pages = 265–76 | date = April 2015 | pmid = 25797516 | doi = 10.1016/j.it.2015.02.008 }}
8. ^1 {{cite journal | vauthors = Mahoney KM, Rennert PD, Freeman GJ | title = Combination cancer immunotherapy and new immunomodulatory targets | journal = Nature Reviews. Drug Discovery | volume = 14 | issue = 8 | pages = 561–84 | date = August 2015 | pmid = 26228759 | doi = 10.1038/nrd4591 }}
9. ^1 {{cite journal | vauthors = Anderson AC, Joller N, Kuchroo VK | title = Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation | journal = Immunity | volume = 44 | issue = 5 | pages = 989–1004 | date = May 2016 | pmid = 27192565 | pmc = 4942846 | doi = 10.1016/j.immuni.2016.05.001 }}
10. ^1 {{cite journal | vauthors = Nishimura H, Nose M, Hiai H, Minato N, Honjo T | title = Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor | journal = Immunity | volume = 11 | issue = 2 | pages = 141–51 | date = August 1999 | pmid = 10485649 | doi = | url = }}
11. ^1 {{cite journal | vauthors = Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH | title = Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 | journal = Immunity | volume = 3 | issue = 5 | pages = 541–7 | date = November 1995 | pmid = 7584144 | doi = | url = }}
12. ^1 {{cite journal | vauthors = Gründemann C, Schwartzkopff S, Koschella M, Schweier O, Peters C, Voehringer D, Pircher H | title = The NK receptor KLRG1 is dispensable for virus-induced NK and CD8+ T-cell differentiation and function in vivo | journal = European Journal of Immunology | volume = 40 | issue = 5 | pages = 1303–14 | date = May 2010 | pmid = 20201037 | doi = 10.1002/eji.200939771 }}
13. ^1 {{cite journal | vauthors = Cyktor JC, Carruthers B, Stromberg P, Flaño E, Pircher H, Turner J | title = Killer cell lectin-like receptor G1 deficiency significantly enhances survival after Mycobacterium tuberculosis infection | journal = Infection and Immunity | volume = 81 | issue = 4 | pages = 1090–9 | date = April 2013 | pmid = 23340310 | pmc = 3639586 | doi = 10.1128/IAI.01199-12 }}
14. ^1 {{cite journal | vauthors = Melis L, Van Praet L, Pircher H, Venken K, Elewaut D | title = Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-α production by interaction with its soluble E-cadherin ligand in chronically inflamed joints | journal = Annals of the Rheumatic Diseases | volume = 73 | issue = 6 | pages = 1223–31 | date = June 2014 | pmid = 23740233 | doi = 10.1136/annrheumdis-2013-203881 }}
15. ^1 {{cite journal | vauthors = Akbar AN, Henson SM | title = Are senescence and exhaustion intertwined or unrelated processes that compromise immunity? | journal = Nature Reviews. Immunology | volume = 11 | issue = 4 | pages = 289–95 | date = April 2011 | pmid = 21436838 | doi = 10.1038/nri2959 }}
16. ^1 {{cite journal | vauthors = Henson SM, Akbar AN | title = KLRG1--more than a marker for T cell senescence | journal = Age (Dordrecht, Netherlands) | volume = 31 | issue = 4 | pages = 285–91 | date = December 2009 | pmid = 19479342 | pmc = 2813054 | doi = 10.1007/s11357-009-9100-9 }}
[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]
}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Ortega E, Schneider H, Pecht I | title = Possible interactions between the Fc epsilon receptor and a novel mast cell function-associated antigen | journal = International Immunology | volume = 3 | issue = 4 | pages = 333–42 | date = April 1991 | pmid = 1831652 | doi = 10.1093/intimm/3.4.333 }}
  • {{cite journal | vauthors = Lamers MB, Lamont AG, Williams DH | title = Human MAFA has alternatively spliced variants | journal = Biochimica et Biophysica Acta | volume = 1399 | issue = 2-3 | pages = 209–12 | date = August 1998 | pmid = 9765598 | doi = 10.1016/s0167-4781(98)00107-9 }}
  • {{cite journal | vauthors = Voehringer D, Koschella M, Pircher H | title = Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1) | journal = Blood | volume = 100 | issue = 10 | pages = 3698–702 | date = November 2002 | pmid = 12393723 | doi = 10.1182/blood-2002-02-0657 }}
  • {{cite journal | vauthors = Matsuoka TA, Artner I, Henderson E, Means A, Sander M, Stein R | title = The MafA transcription factor appears to be responsible for tissue-specific expression of insulin | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 9 | pages = 2930–3 | date = March 2004 | pmid = 14973194 | pmc = 365722 | doi = 10.1073/pnas.0306233101 }}
  • {{cite journal | vauthors = Marcolino I, Przybylski GK, Koschella M, Schmidt CA, Voehringer D, Schlesier M, Pircher H | title = Frequent expression of the natural killer cell receptor KLRG1 in human cord blood T cells: correlation with replicative history | journal = European Journal of Immunology | volume = 34 | issue = 10 | pages = 2672–80 | date = October 2004 | pmid = 15368283 | doi = 10.1002/eji.200425282 }}
  • {{cite journal | vauthors = Ibegbu CC, Xu YX, Harris W, Maggio D, Miller JD, Kourtis AP | title = Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57 | journal = Journal of Immunology | volume = 174 | issue = 10 | pages = 6088–94 | date = May 2005 | pmid = 15879103 | doi = 10.4049/jimmunol.174.10.6088 }}
  • {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
  • {{cite journal | vauthors = Bengsch B, Spangenberg HC, Kersting N, Neumann-Haefelin C, Panther E, von Weizsäcker F, Blum HE, Pircher H, Thimme R | title = Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver | journal = Journal of Virology | volume = 81 | issue = 2 | pages = 945–53 | date = January 2007 | pmid = 17079288 | pmc = 1797464 | doi = 10.1128/JVI.01354-06 }}
  • {{cite journal | vauthors = Schwartzkopff S, Gründemann C, Schweier O, Rosshart S, Karjalainen KE, Becker KF, Pircher H | title = Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans | journal = Journal of Immunology | volume = 179 | issue = 2 | pages = 1022–9 | date = July 2007 | pmid = 17617594 | doi = 10.4049/jimmunol.179.2.1022 }}
{{refend}}

External links

  • {{UCSC genome browser|KLRG1}}
  • {{UCSC gene details|KLRG1}}
{{gene-12-stub}}
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