| 词条 | KREMEN1 |
| 释义 |
Kremen protein 1 is a protein that in humans is encoded by the KREMEN1 gene.[1][2] Kremen1 is conserved in chordates including amphioxus[3] and most vertebrate species.[4] The protein is a type I transmembrane receptor of ligands Dickkopf1,[4] Dickkopf2, Dickkopf3, Dickkopf4, EpCAM[5] and Rspondin1. == Function == {{PBB_Summary| section_title = | summary_text = This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.[2] }} Kremen1 also has a function in the induction of cell death by apoptosis.[6] This proapototic activity is conditional and depends on the absence of ligand Dickkopf1.[6] These observations led to the classification of this protein as a Dependence Receptor. A mouse knock out of Kremen1 and its paralog Kremen2 is viable and fertile.[7] References1. ^{{cite journal |vauthors=Nakamura T, Aoki S, Kitajima K, Takahashi T, Matsumoto K, Nakamura T | title = Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein | journal = Biochim Biophys Acta | volume = 1518 | issue = 1-2 | pages = 63–72 |date=Mar 2001 | pmid = 11267660 | pmc = | doi = 10.1016/s0167-4781(01)00168-3}} 2. ^1 {{cite web | title = Entrez Gene: KREMEN1 kringle containing transmembrane protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83999| accessdate = }} 3. ^{{Cite journal|last=Zhang|first=Yujun|last2=Mao|first2=Bingyu|date=2010-09-01|title=Embryonic expression and evolutionary analysis of the amphioxus Dickkopf and Kremen family genes|journal=Journal of Genetics and Genomics = Yi Chuan Xue Bao|volume=37|issue=9|pages=637–645|doi=10.1016/S1673-8527(09)60082-5|issn=1673-8527|pmid=20933216}} 4. ^{{Cite journal|last=Mao|first=Bingyu|last2=Wu|first2=Wei|last3=Davidson|first3=Gary|last4=Marhold|first4=Joachim|last5=Li|first5=Mingfa|last6=Mechler|first6=Bernard M.|last7=Delius|first7=Hajo|last8=Hoppe|first8=Dana|last9=Stannek|first9=Peter|date=2002-06-06|title=Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling|journal=Nature|volume=417|issue=6889|pages=664–667|doi=10.1038/nature756|issn=0028-0836|pmid=12050670}} 5. ^{{Cite journal|last=Lu|first=Huiqiang|last2=Ma|first2=Jun|last3=Yang|first3=Yun|last4=Shi|first4=Wenchao|last5=Luo|first5=Lingfei|date=2013-03-11|title=EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development|journal=Developmental Cell|volume=24|issue=5|pages=543–553|doi=10.1016/j.devcel.2013.01.021|issn=1878-1551|pmid=23484855}} 6. ^1 2 {{Cite journal|last=Causeret|first=F.|last2=Sumia|first2=I.|last3=Pierani|first3=A.|date=2016-02-01|title=Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner|journal=Cell Death and Differentiation|volume=23|issue=2|pages=323–332|doi=10.1038/cdd.2015.100|issn=1476-5403|pmc=4716294|pmid=26206087}} 7. ^{{Cite journal|last=Ellwanger|first=Kristina|last2=Saito|first2=Hiroaki|last3=Clément-Lacroix|first3=Philippe|last4=Maltry|first4=Nicole|last5=Niedermeyer|first5=Joachim|last6=Lee|first6=Woon Kyu|last7=Baron|first7=Roland|last8=Rawadi|first8=Georges|last9=Westphal|first9=Heiner|date=2008-08-01|title=Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density|journal=Molecular and Cellular Biology|volume=28|issue=15|pages=4875–4882|doi=10.1128/MCB.00222-08|issn=1098-5549|pmc=2493355|pmid=18505822}} Further reading{{refbegin | 2}}
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