| 词条 | Krzysztof Palczewski |
| 释义 |
| name = Krzysztof Palczewski | native_name = | native_name_lang = | image = | imagesize = | alt = | caption = | birth_date = 1957 | birth_place = Syców, Poland | death_date = | death_place = | death_cause = | resting_place = | resting_place_coordinates = | other_names = | residence = | citizenship = Polish | nationality = | fields = Biochemistry | workplaces = Case Western Reserve University; University of California, Irvine | patrons = | alma_mater = University of Wrocław, Wrocław University of Technology | thesis_title = | thesis_url = | thesis_year = | doctoral_advisor = Marian Kochman | academic_advisors = | doctoral_students = | notable_students = | known_for = Rhodopsin | influences = | influenced = | awards = Humboldt Research Award Prize of the Foundation for Polish Science (2012)[1] ARVO Friedenwald award (2014) [2]Beckman-Argyros award in Vision Research (2015) Bressler Award in Vision Science (2015)[3] Polish Academy of Arts and Sciences (2015, foreign member) RRF Paul Kayser International Award in Retina Research (2018) | author_abbrev_bot = | author_abbrev_zoo = | spouse = | partner = | children = | signature = | signature_alt = | website = [https://www.faculty.uci.edu/profile.cfm?faculty_id=6503] | footnotes = }}Krzysztof Palczewski is a Polish biochemist working at the University of California, Irvine. In 2012 he was awarded Prize of the Foundation for Polish Science, the most prestigious scientific award for Polish scientists, for characterizing crystal structures of native and activated G protein-coupled receptor, rhodopsin, involved in eyesight.[1] His MS and PhD, are from the University of Wroclaw and Technical University of Wroclaw, respectively (Poland). His early posts were at the University of Florida and the Oregon Health Sciences University. Dr. Palczewski completed much of his pivotal research at the University of Washington. In 2005 he moved to become the Chair and John H. Hord professor of Pharmacology at Case Western Reserve University, where in 2016 he was appointed as Distinguished Professor of the Case Western Reserve University. In 2018 he joined University of California, Irvine, and is leading the Center for Translational Vision Research[4]. He is the founder of two drug discovery companies, Polgenix and Retinagenix. Research interestsPalczewski's research interest lie in mapping the Visual Transduction System. His work with determining the crystal structure of rhodopsin has given new insight into the function of G protein receptors. Furthermore, his work on visual cycle has led to revolutionary advances in understanding hereditary blindness, leading to implementation of novel pharmacological treatments that can slow retinal degeneration in adults.[5][6] His team's latest efforts indicate that repetitive 2-photon imaging of the human eye can safely reveal the visual system's subcellular architecture and that humans can detect infrared light due to simultaneous 2-photon absorption. [7][8]ReferencesNotes1. ^1 {{cite web | url=http://www.fnp.org.pl/en/prof-krzysztof-palczewski/ | title=Prof. Krzysztof Palczewski - FNP Prize 2012 laureate}} 2. ^{{Cite journal | url=http://iovs.arvojournals.org/article.aspx?articleid=2166599 | doi=10.1167/iovs.14-14843| pmid=25338685| title=Introducing Krzysztof Palczewski, the 2014 Recipient of the Friedenwald Award| journal=Investigative Ophthalmology & Visual Science| volume=55| issue=10| pages=6649–50| year=2014| last1=Polans| first1=Arthur S.}} 3. ^{{cite web | url=http://www.lighthouseguild.org/programs-services/awards/bressler-prize-in-vision-science/recipients/ | title=Lighthouse Guild | Bressler Prize in Vision Science Recipients}} 4. ^https://faculty.sites.uci.edu/ctvr/ 5. ^{{Cite journal | url=http://www.pnas.org/content/102/17/6177.long | doi=10.1073/pnas.0500646102| pmid=15837919| pmc=1087926| title=Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success| journal=Proceedings of the National Academy of Sciences| volume=102| issue=17| pages=6177–6182| year=2005| last1=Jacobson| first1=S. G.| last2=Aleman| first2=T. S.| last3=Cideciyan| first3=A. V.| last4=Sumaroka| first4=A.| last5=Schwartz| first5=S. B.| last6=Windsor| first6=E. A. M.| last7=Traboulsi| first7=E. I.| last8=Heon| first8=E.| last9=Pittler| first9=S. J.| last10=Milam| first10=A. H.| last11=Maguire| first11=A. M.| last12=Palczewski| first12=K.| last13=Stone| first13=E. M.| last14=Bennett| first14=J.}} 6. ^{{cite journal|doi=10.1021/bi052382x | pmid=16566595 | volume=45 | issue=13 | title=Aberrant Metabolites in Mouse Models of Congenital Blinding Diseases: Formation and Storage of Retinyl Esters† | journal=Biochemistry | pages=4210–4219 | last1 = Maeda | first1 = Akiko| pmc=1560103 | year=2006 }} 7. ^{{Cite journal | url=http://www.nature.com/nm/journal/v20/n7/abs/nm.3590.html | doi=10.1038/nm.3590| pmid=24952647| pmc=4087080| title=Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye| journal=Nature Medicine| volume=20| issue=7| pages=785–789| year=2014| last1=Palczewska| first1=Grazyna| last2=Dong| first2=Zhiqian| last3=Golczak| first3=Marcin| last4=Hunter| first4=Jennifer J.| last5=Williams| first5=David R.| last6=Alexander| first6=Nathan S.| last7=Palczewski| first7=Krzysztof}} 8. ^{{Cite journal | url=http://www.pnas.org/content/111/50/E5445.full | doi=10.1073/pnas.1410162111| pmid=25453064| pmc=4273384| title=Human infrared vision is triggered by two-photon chromophore isomerization| journal=Proceedings of the National Academy of Sciences| volume=111| issue=50| pages=E5445–E5454| year=2014| last1=Palczewska| first1=Grazyna| last2=Vinberg| first2=Frans| last3=Stremplewski| first3=Patrycjusz| last4=Bircher| first4=Martin P.| last5=Salom| first5=David| last6=Komar| first6=Katarzyna| last7=Zhang| first7=Jianye| last8=Cascella| first8=Michele| last9=Wojtkowski| first9=Maciej| last10=Kefalov| first10=Vladimir J.| last11=Palczewski| first11=Krzysztof}} Bibliography
External links
3 : Polish pharmacologists|Living people|1957 births |
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